Search Results - "Niemeyer, Ulf"

Urinary Excretion of Cyclophosphamide in Humans, Determined by Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy by JOQUEVIEL, C, MARTINO, R, GILARD, V, MALET-MARTINO, M, CANAL, P, NIEMEYER, U

“…Phosphorus-31 NMR spectroscopy was used to analyze urine samples from patients treated with cyclophosphamide (CP) on 2 consecutive days. CP and all of its…”
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Comparison of In Vitro Antileukemic Activity of 4-Hydroperoxyifosfamide and 4-Hydroperoxycyclophosphamide by Opydo-Chanek, Malgorzata, Śladowska, Katarzyna, Blicharski, Kamil, Mikeš, Jaromir, Fedoročko, Peter, Niemeyer, Ulf, Mazur, Lidia

“…The oxazaphosphorines, ifosfamide and cyclophosphamide, represent a class of alkylating agents. The aim of the present in vitro study was to compare…”
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In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells by Mazur, Lidia, Opydo-Chanek, Małgorzata, Stojak, Marta, Niemeyer, Ulf

“…Mafosfamide cyclohexylamine salt (D-17272), 4-hydro-peroxy-cyclophosphamide (D-18864) and glufosfamide (D-19575, β-D-glucose-isophosphoramide mustard) are new…”
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Chemical and Biological Evaluation of Hydrolysis Products of Cyclophosphamide by Gilard, Veronique, Martino, Robert, Malet-Martino, Marie-C., Kutscher, Bernhard, Mueller, Arndt, Niemeyer, Ulf, Pohl, Joerg, Polymeropoulos, Emmanuel E.

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Comparative Effects of New Generation Oxazaphosphorines on the Size and Viability of Human Acute Myeloblastic Leukemia Cells by Mazur, Lidia, Opydo-Chanek, Maĺgorzata, Wojcieszek, Katarzyna, Stojak, Marta, Niemeyer, Ulf

“…Mafosfamide cyclohexylamine salt (D-17272), 4-hydro-peroxy-cyclophosphamide (D-18864), and β-D-glucose-isophosphoramide mustard (D-19575, glufosfamide) are…”
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Induction of DNA Breakage in U937 Cells by Oxazaphosphorines by Mazur, Lidia, Opydo-Chanek, Małgorzata, Stojak, Marta, Baran, Jarosław, Niemeyer, Ulf

“…Oxazaphosphorines are a class of DNA alkylating agents. The aim of the present study was to compare the possible influence of three new generation…”
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Chemical Stability and Fate of the Cytostatic Drug Ifosfamide and Its N-Dechloroethylated Metabolites in Acidic Aqueous Solutions by Gilard, Véronique, Martino, Robert, Malet-Martino, Myriam, Niemeyer, Ulf, Pohl, Jörg

“…31P NMR spectroscopy was used to study the products of the decomposition of the antitumor drug ifosfamide (IF, 1d) and its N-dechloroethylated metabolites,…”
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Investigations on the pharmacokinetics of trofosfamide and its metabolites: first report of 4-hydroxy-trofosfamide kinetics in humans by PREISS, Rainer, BAUMANN, Frank, STEFANOVIC, Dragan, NIEMEYER, Ulf, PÖNISCH, Wolfgang, NIEDERWIESER, Dietger

“…Trofosfamide (TRO), like cyclophosphamide (CYCLO) and ifosfamide (IFO), is a prodrug oxazaphosphorine derivative that requires hepatic biotransformation to…”
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Identification of new aqueous chemical degradation products of isophosphoramide mustard by BREIL, Stéphane, MARTINO, Robert, GILARD, Véronique, MALET-MARTINO, Myriam, NIEMEYER, Ulf

“…NMR (31P, 1H and 13C) spectroscopy was used to study the products of the degradation of isophosphoramide mustard (IPM) in buffered solutions at pH ranging from…”
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STABILITY OF COMMERCIAL FORMULATIONS AND AQUEOUS SOLUTIONS OF IFOSFAMIDE by Veronique Gilard, Robert Martino, Myriam Malet-Martino, Ulf Niemeyer

“…This study is a reply to a paper in this journal reporting on the chemical instability of ifosfamide (IF) ( Drug Metab. Dispos. 23, 433–437, 1995). The…”
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BENZODIAZA-, BENZOXAZA-, AND BENZODIOXAPHOSPHORINONES - FORMATION, REACTIVITY, STRUCTURE, AND BIOLOGICAL ACTIVITY by Neda, Ion, Kaukorat, Thomas, Schmutzler, Reinhard, Niemeyer, Ulf, Kutscher, Bernhard, Pohl, Jörg

“…Although diverse phosphorus-containing heterocycles had been synthe-sized during the late nineteenth century already, work was still sparse in this area as…”
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Highly Diastereoselective Synthesis of Anomeric β-O-Glycopyranosyl σ 3 λ 3 -and σ 4 λ 5 -Phosphorus Compounds by Neda, Ion, Schmutzler, Reinhard, Niemeyer, Ulf, Kutscher, Bernhard, Engel, Jürgen

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Alkaline Hydrolytic Pathway of the Antitumor Drug, Cyclophosphamide by Gilard, Veronique, Malet-martino, Myriam, Martino, Robert, Niemeyer, Ulf

“…In an attempt to clarify the alkaline hydrolytic pathway of the antitumor agent, cyclophosphamide (CP), the time course of its degradation was monitored by 31…”
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Alkaline Hydrolysis of the Cytostatic Drug, Ifosfamide, and its N-Dechloroethylated Metabolites by Gilard, Veronique, Malet-martino, Myriam, Martino, Robert, Niemeyer, Ulf

“…I fosfamide (IF) is an alkylating antitumor agent used in the treatment of solid tumors. Up to 50% of IF administered to patients undergoes an oxidative…”
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Highly Diastereoselective Synthesis of Anomeric β-O-Glycopyranosyl σ3λ3-and σ4λ5-Phosphorus Compounds by Neda, Ion, Schmutzler, Reinhard, Niemeyer, Ulf, Kutscher, Bernhard, Engel, Jürgen

“…A new method for the highly stereoselective synthesis of β-O-σ 3 λ 3 and σ 4 λ 4 phosphorus-substituted 2,3,4,6-tetrabcnzylglucose is presented. The…”
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Hydrolytic Pathway of Isophosphoramide Mustard (IPM), the Cytotoxic Metabolite of the Anticancer Drug Ifosfamide by Breil, Stephane, Gilard, Veronique, Legay, Remi, Martino, Robert, Malet-Martino, Myriam, Niemeyer, Ulf

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Urinary stability of carboxycyclophosphamide and carboxyifosfamide, two major metabolites of the anticancer drugs cyclophosphamide and ifosfamide by JOQUEVIEL, C, GILARD, V, MARTINO, R, MALET-MARTINO, M, NIEMEYER, U

“…Phosphorus-31 nuclear magnetic resonance spectroscopy was used to evaluate the stability of carboxycyclophosphamide (CXCP) and carboxyifosfamide (CXIF) in…”
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Stability of commercial formulations and aqueous solutions of ifosfamide : A reply by GILARD, V, MARTINO, R, MALET-MARTINO, M, NIEMEYER, U

“…This study is a reply to a paper in this journal reporting on the chemical instability of ifosfamide (IF) (Drug Metab. Dispos. 23, 433-437, 1995). The authors…”
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Hydrolytic Pathway of Glufosfamide, a New Phosphorylated Anticancer Agent by de Rouvèze, Marie-Caroline Aoust, Gilard, Veronique, Martino, Robert, Malet-Martino, Myriam, Niemeyer, Ulf

“…31 P NMR was used to demonstrate that glufosfamide is hydrolyzed into isophosphoramide mustard (IPM) with a half-life of about 25 h at 37;C and pH 7.4 in…”
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31 P NMR Determination of the Urinary Excretion of the Antitumor Drug Cyclophosphamide in Humans by Joqueviel, Claire, Martino, Robert, Gilard, Veronique, Malet-martino, Myriam, Niemeyer, Ulf

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