Search Results - "Nielsen, Søren J."

Relative Atrial Natriuretic Peptide Deficiency and Inadequate Renin and Angiotensin II Suppression in Obese Hypertensive Men by Asferg, Camilla L, Nielsen, Søren J, Andersen, Ulrik B, Linneberg, Allan, Møller, Daniel V, Hedley, Paula L, Christiansen, Michael, Goetze, Jens P, Esler, Murray, Jeppesen, Jørgen L

“…Obesity is a strong risk factor for hypertension, but the mechanisms by which obesity leads to hypertension are incompletely understood. On this background, we…”
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Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase by Olesen, Uffe H, Petersen, Jakob G, Garten, Antje, Kiess, Wieland, Yoshino, Jun, Imai, Shin-Ichiro, Christensen, Mette K, Fristrup, Peter, Thougaard, Annemette V, Björkling, Fredrik, Jensen, Peter B, Nielsen, Søren J, Sehested, Maxwell

“…Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and…”
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Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-ones by Christensen, Mette K, Erichsen, Kamille D, Trojel-Hansen, Christina, Tjørnelund, Jette, Nielsen, Søren J, Frydenvang, Karla, Johansen, Tommy N, Nielsen, Birgitte, Sehested, Maxwell, Jensen, Peter B, Ikaunieks, Martins, Zaichenko, Andrei, Loza, Einars, Kalvinsh, Ivars, Björkling, Fredrik

“…Optimization of the anticancer activity for a class of compounds built on a 1,3-dihydroindole-2-one scaffold was performed. In comparison with recently…”
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Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men by Asferg, Camilla L., Nielsen, Søren J., Andersen, Ulrik B., Linneberg, Allan, Møller, Daniel V., Hedley, Paula L., Christiansen, Michael, Gøtze, Jens P., Jeppesen, Jørgen L.

“…BACKGROUND Several studies have shown that obese persons have lower circulating natriuretic peptide (NP) concentrations. The cause of the relative NP…”
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LNA-based oligonucleotide electrotransfer for miRNA inhibition by Chabot, Sophie, Orio, Julie, Castanier, Romain, Bellard, Elisabeth, Nielsen, Søren J, Golzio, Muriel, Teissié, Justin

“…Micro-RNAs (miRNAs) are small regulatory RNAs that play an important role in disease development and progression and therefore represent a potential new class…”
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Rb targets histone H3 methylation and HP1 to promoters by Kouzarides, Tony, Nielsen, Soren J, Schneider, Robert, Bauer, Uta-Maria, Bannister, Andrew J, Morrison, Ashby, O'Carroll, Donal, Firestein, Ron, Cleary, Michael, Jenuwein, Thomas, Herrera, Rafael E

“…In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein HP1 functionally interact to repress transcription at heterochromatic…”
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Serum proatrial natriuretic peptide concentrations during oral glucose-induced acute hyperinsulinemia in lean and obese men by Asferg, Camilla L., Nielsen, Søren J., Andersen, Ulrik B., Linneberg, Allan, Goetze, Jens P., Jeppesen, Jørgen L.

“…•Atrial natriuretic peptide (ANP) is low in obese hyperinsulinemic persons.•It has been proposed that insulin lowers ANP secretion through a direct…”
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Regulation of E2F1 activity by acetylation by Martínez-Balbás, Marian A., Bauer, Uta-Maria, Nielsen, Søren J., Brehm, Alexander, Kouzarides, Tony

“…During the G1 phase of the cell cycle, an E2F–RB complex represses transcription, via the recruitment of histone deacetylase activity. Phosphorylation of RB at…”
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Methylation at arginine 17 of histone H3 is linked to gene activation by Bauer, Uta-Maria, Daujat, Sylvain, Nielsen, Søren J, Nightingale, Karl, Kouzarides, Tony

“…The nuclear hormone receptor co‐activator CARM1 has the potential to methylate histone H3 at arginine residues in vitro. The methyltransferase activity of…”
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HDAC4 deacetylase associates with and represses the MEF2 transcription factor by Miska, Eric A., Karlsson, Christina, Langley, Emma, Nielsen, Søren J., Pines, Jon, Kouzarides, Tony

“…The acetylation state of histones can influence transcription. Acetylation, carried out by acetyltransferases such as CBP/p300 and P/CAF, is commonly…”
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ProCNP and CNP are expressed primarily in male genital organs by NIELSEN, Søren J, GØTZE, Jens Peter, JENSEN, Helle L, REHFELD, Jens F

“…Lack of knowledge about the cellular origin of C-type natriuretic peptides (CNP) in the body has hampered the understanding of their biology. We examined the…”
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The Co-repressor mSin3A Is a Functional Component of the REST-CoREST Repressor Complex by Grimes, Julia A., Nielsen, Søren J., Battaglioli, Elena, Miska, Eric A., Speh, Joan C., Berry, Dianna L., Atouf, Fouad, Holdener, Bernadette C., Mandel, Gail, Kouzarides, Tony

“…The repressor REST/NRSF restricts expression of a large set of genes to neurons by suppressing their expression in non-neural tissues. We find that REST…”
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Genetic Variation in the Natriuretic Peptide System, Circulating Natriuretic Peptide Levels, and Blood Pressure: An Ambulatory Blood Pressure Study by JEPPESEN, Jørgen L, NIELSEN, Søren J, TORP-PEDERSEN, Christian, HANSEN, Tine W, OLSEN, Michael H, BERG, Nikolaj D, LINNEBERG, Allan, MADSBAD, Sten, FENGER, Mogens

“…In a large collaborative study (n > 50,000), common variants in the natriuretic peptide (NP) genes were found to be associated with circulating NP levels and…”
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The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth by Brehm, Alexander, Nielsen, Søren J., Miska, Eric A., McCance, Dennis J., Reid, Juliet L., Bannister, Andrew J., Kouzarides, Tony

“…E7 is the main transforming protein of human papilloma virus type 16 (HPV16) which is implicated in the formation of cervical cancer. The transforming activity…”
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Tyrosine Hydroxylase Polymorphism (C-824T) and Hypertension: A Population-Based Study by Nielsen, Søren J., Jeppesen, Jørgen, Torp-Pedersen, Christian, Hansen, Tine W., Linneberg, Allan, Fenger, Mogens

“…Background Sympathetic nervous system (SNS) overactivity is present in a large proportion of the hypertensive population and precedes the development of…”
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LNA-based Oligonucleotide Electrotransfer for miRNA Inhibition by Chabot, Sophie, Orio, Julie, Castanier, Romain, Bellard, Elisabeth, Nielsen, Søren J, Golzio, Muriel, Teissié, Justin

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Swift Is a Novel BRCT Domain Coactivator of Smad2 in Transforming Growth Factor β Signaling by Shimizu, Kazuya, Bourillot, Pierre-Yves, Nielsen, Søren J., Zorn, Aaron M., Gurdon, J. B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nuclear export inhibitors and kinase inhibitors identified using a MAPK-activated protein kinase 2 redistribution screen by Almholt, Dorthe L C, Loechel, Frosty, Nielsen, Søren J, Krog-Jensen, Christian, Terry, Robert, Bjørn, Sara P, Pedersen, Hans C, Praestegaard, Morten, Møller, Søren, Heide, Morten, Pagliaro, Len, Mason, Anthony J, Butcher, Steven, Dahl, Søren W

“…Redistribution (BioImage) A/S, Søborg, Denmark) is a novel high-throughput screening technology that monitors translocation of specific protein components of…”
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Abstract LB-135: Selective small molecule inhibition of the N-terminal BET bromodomain by Seitzberg, Jimmi G., Hansen, Margit H., Kronborg, Tine T. Akinleminu, Underwood, Christina R., Friberg, Gitte, Tonnesen, Berit, Teuber, Lene, Franch, Thomas, Nielsen, Søren J.

“…Abstract Introduction: The bromodomain acetyl-lysine ‘readers’ is an emerging target class with particular interest centered around the BET family proteins…”
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Abstract LB-476: A universal method for elimination of haemolyzed plasma samples that improves miRNA signature performance for early detection of colorectal cancer by Nielsen, Søren J., Blondal, Thorarinn, Teilum, Maria W., Andersen, Claus L., Orntoft, Torben, Brünner, Nils, Stenvang, Jan, Nielsen, Hans J., Baker, Adam, Mouritzen, Peter

“…Abstract microRNAs (miRNAs) are short (∼21 bp) non-coding RNAs that regulate gene expression through post-transcriptional interactions with target messenger…”
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