Comorbidity is an independent prognostic factor in women with uterine corpus cancer: a nationwide cohort study

To determine whether comorbidity independently affects overall survival in women with uterine corpus cancer. Cohort study. Denmark. A total of 4244 patients registered in the Danish Gynecologic Cancer database with uterine corpus cancer from 1 January 2005 until 13 October 2011. All patients include...

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Bibliographic Details
Published in:	Acta obstetricia et gynecologica Scandinavica Vol. 93; no. 4; p. 325
Main Authors:	Noer, Mette C, Sperling, Cecilie, Christensen, Ib J, Nielsen, Marie L S, Lidegaard, Ojvind, Høgdall, Claus
Format:	Journal Article
Language:	English
Published:	United States 01-04-2014
Subjects:	Adenocarcinoma - mortality Adult Aged Aged, 80 and over Carcinoma - mortality Cohort Studies Comorbidity Denmark - epidemiology Female Humans Kaplan-Meier Estimate Middle Aged Neoplasm Grading Neoplasm Staging Neoplasm, Residual - mortality Predictive Value of Tests Prognosis Risk Factors Sarcoma - mortality Uterine Neoplasms - mortality Uterine Neoplasms - pathology Denmark Uterine corpus cancer performance status comorbidity prognostic factor Charlson Comorbidity Index survival
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Summary:	To determine whether comorbidity independently affects overall survival in women with uterine corpus cancer. Cohort study. Denmark. A total of 4244 patients registered in the Danish Gynecologic Cancer database with uterine corpus cancer from 1 January 2005 until 13 October 2011. All patients included in the study were assigned a comorbidity score according to the Charlson Comorbidity Index. Multivariate survival analyses were performed to investigate the prognostic impact of comorbidity adjusting for known prognostic factors. As performance status might capture the prognostic impact of comorbidity and because information on the variable grade was missing in some special histological subtypes, we included different models in the multivariate analyses with and without PS and grade, respectively. Overall survival. Univariate survival analysis showed a significant (p < 0.001) negative association between increasing level of comorbidity and overall survival. Multivariate analyses adjusting for other prognostic factors showed that comorbidity is a significant independent prognostic factor with hazard ratios ranging from 1.27 to 1.42 in mild, 1.69 to 1.74 in moderate, and 1.72 to 2.48 in severe comorbidity. Performance status was independently associated to overall survival and was found to slightly reduce the prognostic impact of comorbidity. Comorbidity is an independent prognostic factor in uterine corpus cancer and increasing levels of comorbidity are associated with shorter survival.
ISSN:	1600-0412
DOI:	10.1111/aogs.12338