Search Results - "Nielsen, Jens E"

Temporal changes and clinical significance of peridevice leak following left atrial appendage occlusion with Amplatzer devices by Korsholm, Kasper, Jensen, Jesper M., Nørgaard, Bjarne L., Nielsen‐Kudsk, Jens E.

“…Background The natural history of peridevice leak (PDL) following left atrial appendage occlusion (LAAO) is unknown. This study sought to investigate changes…”
Get full text

Intracardiac echocardiography for guidance of transcatheter left atrial appendage occlusion: An expert consensus document by Berti, Sergio, Pastormerlo, Luigi E., Korsholm, Kasper, Saw, Jacqueline, Alkhouli, Mohamad, Costa, Marco P., Odenstedt, Jacob, Packer, Erik JS, Tondo, Claudio, Santoro, Gennaro, Nielsen‐Kudsk, Jens E.

“…Transcatheter left atrial appendage occlusion (LAAO) is an increasingly used alternative to oral anticoagulation in selected patients with atrial fibrillation…”
Get full text

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity by Cummins, Eoin P., Berra, Edurne, Comerford, Katrina M., Ginouves, Amandine, Fitzgerald, Kathleen T., Seeballuck, Fergal, Godson, Catherine, Nielsen, Jens E., Moynagh, Paul, Pouyssegur, Jacques, Taylor, Cormac T.

“…Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NFκB is activated in hypoxia, an event that has significant…”
Get full text

The pKa Cooperative: A collaborative effort to advance structure-based calculations of pKa values and electrostatic effects in proteins by Nielsen, Jens E., Gunner, M. R., García-Moreno E., Bertrand

“…The pKa Cooperative (http://www.pkacoop.org) was organized to advance development of accurate and useful computational methods for structure‐based calculation…”
Get full text

Fiducial marker guided stereotactic liver radiotherapy: Is a time delay between marker implantation and planning CT needed? by Worm, Esben S, Bertholet, Jenny, Høyer, Morten, Fledelius, Walther, Hansen, Anders T, Larsen, Lars P, Nielsen, Jens E, Poulsen, Per R

“…Abstract To minimize the risk of marker migration in fiducial marker guided liver SBRT it is common to add a delay of a week between marker implantation and…”
Get full text

Heparin Enhances Serpin Inhibition of the Cysteine Protease Cathepsin L by Higgins, Wayne J., Fox, Denise M., Kowalski, Piotr S., Nielsen, Jens E., Worrall, D. Margaret

“…The glycosaminoglycan heparin is known to possess antimetastatic activity in experimental models and preclinical studies, but there is still uncertainty over…”
Get full text

Five-Year Outcomes of PFO Closure or Antiplatelet Therapy for Cryptogenic Stroke by Kasner, Scott E, Rhodes, John F, Andersen, Grethe, Iversen, Helle K, Nielsen-Kudsk, Jens E, Settergren, Magnus, Sjöstrand, Christina, Roine, Risto O, Hildick-Smith, David, Spence, J. David, Søndergaard, Lars

“…In the initial report of the Gore REDUCE trial of patent foramen ovale closure, with a median follow-up of 3.2 years, 18 patients had stroke recurrence (6 in…”
Get full text

Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis by Wu, Shanshan, Nguyen, Tam T T N, Moroz, Olga V, Turkenburg, Johan P, Nielsen, Jens E, Wilson, Keith S, Rand, Kasper D, Teilum, Kaare

“…Several examples have emerged of enzymes where slow conformational changes are of key importance for function and where low populated conformations in the…”
Get full text

On-Line Use of Three-Dimensional Marker Trajectory Estimation From Cone-Beam Computed Tomography Projections for Precise Setup in Radiotherapy for Targets With Respiratory Motion by Worm, Esben S., M.Sc, Høyer, Morten, M.D., Ph.D, Fledelius, Walther, Ph.D, Nielsen, Jens E., M.D, Larsen, Lars P., M.D, Poulsen, Per R., Ph.D

“…Purpose To develop and evaluate accurate and objective on-line patient setup based on a novel semiautomatic technique in which three-dimensional marker…”
Get full text

The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide by Damen, Ester, Krieger, Elmar, Nielsen, Jens E, Eygensteyn, Jelle, van Leeuwen, Jeroen E M

“…The retromer complex is involved in the retrograde transport of the CI-M6PR (cation-independent mannose 6-phosphate receptor) from endosomes to the Golgi. It…”
Get full text

Web servers and services for electrostatics calculations with APBS and PDB2PQR by Unni, Samir, Huang, Yong, Hanson, Robert M., Tobias, Malcolm, Krishnan, Sriram, Li, Wilfred W., Nielsen, Jens E., Baker, Nathan A.

“…APBS and PDB2PQR are widely utilized free software packages for biomolecular electrostatics calculations. Using the Opal toolkit, we have developed a Web…”
Get full text

PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations by Dolinsky, Todd J, Czodrowski, Paul, Li, Hui, Nielsen, Jens E, Jensen, Jan H, Klebe, Gerhard, Baker, Nathan A

“…Real-world observable physical and chemical characteristics are increasingly being calculated from the 3D structures of biomolecules. Methods for calculating…”
Get full text

Dissecting the Electrostatic Interactions and pH-Dependent Activity of a Family 11 Glycosidase by Joshi, Manish D, Sidhu, Gary, Nielsen, Jens E, Brayer, Gary D, Withers, Stephen G, McIntosh, Lawrence P

“…Previous studies of the low molecular mass family 11 xylanase from Bacillus circulans show that the ionization state of the nucleophile (Glu78, pK a 4.6) and…”
Get full text

Sympathetic nervous system activation and β-adrenoceptor blockade in right heart failure by Andersen, Stine, Andersen, Asger, de Man, Frances S., Nielsen-Kudsk, Jens E.

“…Right heart failure may develop from pulmonary arterial hypertension or various forms of congenital heart disease. Right ventricular adaptation to the…”
Get full text

Riociguat in patients with chronic thromboembolic pulmonary hypertension: results from an early access study by McLaughlin, Vallerie V, Jansa, Pavel, Nielsen-Kudsk, Jens E, Halank, Michael, Simonneau, Gérald, Grünig, Ekkehard, Ulrich, Silvia, Rosenkranz, Stephan, Gómez Sánchez, Miguel A, Pulido, Tomás, Pepke-Zaba, Joanna, Barberá, Joan Albert, Hoeper, Marius M, Vachiéry, Jean-Luc, Lang, Irene, Carvalho, Francine, Meier, Christian, Mueller, Katharina, Nikkho, Sylvia, D'Armini, Andrea M

“…Following positive results from the Phase III CHEST-1 study in patients with inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension…”
Get full text

PDB2PQR: an automated pipeline for the setup of Poisson–Boltzmann electrostatics calculations by Dolinsky, Todd J., Nielsen, Jens E., McCammon, J. Andrew, Baker, Nathan A.

“…Continuum solvation models, such as Poisson–Boltzmann and Generalized Born methods, have become increasingly popular tools for investigating the influence of…”
Get full text

Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase by Synstad, Bjørnar, Gåseidnes, Sigrid, van Aalten, Daan M. F., Vriend, Gert, Nielsen, Jens E, Eijsink, Vincent G. H.

“…Glycoside hydrolysis by retaining family 18 chitinases involves a catalytic acid (Glu) which is part of a conserved DXDXE sequence motif that spans strand four…”
Get full text

Fast empirical pKa prediction by Ewald summation by Krieger, Elmar, Nielsen, Jens E, Spronk, Chris A E M, Vriend, Gert

“…pK(a) calculations for macromolecules are normally performed by solving the Poisson-Boltzmann equation, accounting for the different dielectric constants of…”
Get full text

Optimizing the hydrogen-bond network in Poisson-Boltzmann equation-based pKa calculations by Nielsen, Jens E., Vriend, Gerrit

“…pKa calculation methods that are based on finite difference solutions to the Poisson–Boltzmann equation (FDPB) require that energy calculations be performed…”
Get full text

Gene Panel Testing in Epileptic Encephalopathies and Familial Epilepsies by Møller, Rikke S., Larsen, Line H.G., Johannesen, Katrine M., Talvik, Inga, Talvik, Tiina, Vaher, Ulvi, Miranda, Maria J., Farooq, Muhammad, Nielsen, Jens E.K., Lavard Svendsen, Lene, Kjelgaard, Ditte B., Linnet, Karen M., Hao, Qin, Uldall, Peter, Frangu, Mimoza, Tommerup, Niels, Baig, Shahid M., Abdullah, Uzma, Born, Alfred P., Gellert, Pia, Nikanorova, Marina, Olofsson, Kern, Jepsen, Birgit, Marjanovic, Dragan, Al-Zehhawi, Lana I.K., Peñalva, Sofia J., Krag-Olsen, Bente, Brusgaard, Klaus, Hjalgrim, Helle, Rubboli, Guido, Pal, Deb K., Dahl, Hans A.

“…In recent years, several genes have been causally associated with epilepsy. However, making a genetic diagnosis in a patient can still be difficult, since…”
Get full text