Search Results - "Nielsen, Jens"

Systems Biology of Metabolism by Nielsen, Jens

“…Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic…”
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Yeast Systems Biology: Model Organism and Cell Factory by Nielsen, Jens

“…For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a cell factory for the production of bread, beer, and wine. In more…”
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Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine by Nielsen, Jens

“…Systems biology uses mathematical models to analyze large datasets and simulate system behavior. It enables integrative analysis of different types of data and…”
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Energy metabolism controls phenotypes by protein efficiency and allocation by Chen, Yu, Nielsen, Jens

“…Cells require energy for growth and maintenance and have evolved to have multiple pathways to produce energy in response to varying conditions. A basic…”
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Autotrophic yeast by Nielsen, Jens

“…Yeast is a widely used cell factory for the conversion of sugar into fuels, chemicals and pharmaceuticals. Establishing yeast as being autotrophic can enable…”
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Railway track geometry degradation due to differential settlement of ballast/subgrade – Numerical prediction by an iterative procedure by Nielsen, Jens C.O., Li, Xin

“…An iterative procedure for numerical prediction of long-term degradation of railway track geometry (longitudinal level) due to accumulated differential…”
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Yeast cell factories on the horizon: Metabolic engineering in yeast gets increasingly more versatile by Nielsen, Jens

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Engineering yeast to produce plant-derived anti-obesity agent by Nielsen, Jens

“…Plants produce a wide range of compounds with important bioactivities. Celastrol, an anti-obesity agent found in the root of certain plants, can now be…”
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Assessing the Human Gut Microbiota in Metabolic Diseases by KARLSSON, Fredrik, TREMAROLI, Valentina, NIELSEN, Jens, BÄCKHED, Fredrik

“…Recent findings have demonstrated that the gut microbiome complements our human genome with at least 100-fold more genes. In contrast to our Homo…”
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Recent trends in metabolic engineering of microbial chemical factories by Liu, Yi, Nielsen, Jens

“…[Display omitted] •Microbial cell factories can be tailored for producing certain ‘drop-in’ chemicals.•Metabolic engineering has greatly enhanced the…”
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Synthetic biology for engineering acetyl coenzyme A metabolism in yeast by Nielsen, Jens

“…The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels, chemicals, and pharmaceuticals. The use of this cell factory for…”
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Bioactive metabolites: The double-edged sword in your food by Nielsen, Jens

“…Food contains many different bioactive metabolites that interact with human metabolism. Many of these have health benefits, but in this issue of Cell,…”
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Genome scale metabolic modeling of cancer by Nilsson, Avlant, Nielsen, Jens

“…Cancer cells reprogram metabolism to support rapid proliferation and survival. Energy metabolism is particularly important for growth and genes encoding…”
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Engineering Cellular Metabolism by Nielsen, Jens, Keasling, Jay D.

“…Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to…”
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Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries by Hong, Kuk-Ki, Nielsen, Jens

“…Metabolic engineering is the enabling science of development of efficient cell factories for the production of fuels, chemicals, pharmaceuticals, and food…”
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In vitro turnover numbers do not reflect in vivo activities of yeast enzymes by Chen, Yu, Nielsen, Jens

“…Turnover numbers (k cat values) quantitatively represent the activity of enzymes, which are mostly measured in vitro. While a few studies have reported in vivo…”
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Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods by Väremo, Leif, Nielsen, Jens, Nookaew, Intawat

“…Gene set analysis (GSA) is used to elucidate genome-wide data, in particular transcriptome data. A multitude of methods have been proposed for this step of the…”
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Metagenomic analysis of microbe-mediated vitamin metabolism in the human gut microbiome by Das, Promi, Babaei, Parizad, Nielsen, Jens

“…Human gut microbial communities have been known to produce vitamins, which are subsequently absorbed by the host in the large intestine. However, the…”
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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation by Tremaroli, Valentina, Karlsson, Fredrik, Werling, Malin, Ståhlman, Marcus, Kovatcheva-Datchary, Petia, Olbers, Torsten, Fändriks, Lars, le Roux, Carel W., Nielsen, Jens, Bäckhed, Fredrik

“…Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism…”
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Production of natural products through metabolic engineering of Saccharomyces cerevisiae by Krivoruchko, Anastasia, Nielsen, Jens

“…Graphical abstract…”
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