Search Results - "Nielsen, Jann A."

Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease by Liston, Dane R., Nielsen, Jann A., Villalobos, Anabella, Chapin, Douglas, Jones, Shawn B., Hubbard, Sean T., Shalaby, Ismail A., Ramirez, Andres, Nason, Deane, White, W.Frost

“…Cholinesterase inhibitors vary in their selectivity for acetylcholinesterase versus butyrylcholinesterase. We examined several cholinesterase inhibitors and…”
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3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1) agonist and rotationally restricted phenolic analog of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole by Macor, John E, Burkhart, Carol A, Heym, James H, Ives, Jeffrey L, Lebel, Lorraine A, Newman, Michael E, Nielsen, Jann A, Ryan, Kevin, Schulz, David W

“…The synthesis and in vitro and in vivo characteristics of 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one (1, CP-93,129) are described. This…”
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Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding by Vinick, Fredric J, Saccomano, Nicholas A, Koe, B. Kenneth, Nielsen, Jann A, Williams, Ian H, Thadeio, Peter F, Jung, Stanley, Meltz, Morgan, Johnson, Jonathan, Lebel, Lorraine A, Russo, Lorena L, Helweg, David

“…The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent…”
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Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl-2-imidazolidinones by Saccomano, Nicholas A, Vinick, Frederic J, Koe, B. Kenneth, Nielsen, Jann A, Whalen, William M, Meltz, Morgan, Phillips, Douglas, Thadieo, Peter F, Jung, Stanley, Chapin, Douglas C, Lebel, Lorraine A, Russo, Lorena L, Helweg, David L, Johnson Jr, Jonathan L, Ives, Jeffery L, Williams, Ian H

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Novel Benzisoxazole Derivatives as Potent and Selective Inhibitors of Acetylcholinesterase by Villalobos, Anabella, Blake, James F, Biggers, C. Kelly, Butler, Todd W, Chapin, Douglas S, Chen, Yuhpyng L, Ives, Jeffrey L, Jones, Shawn B, Liston, Dane R

“…A series of N-benzylpiperidine benzisoxazoles has been developed as potent and selective inhibitors of the enzyme acetylcholinesterase (AChE). The…”
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Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes by Nielsen, J A, Mena, E E, Williams, I H, Nocerini, M R, Liston, D

“…9-Amino-1,2,3,4-tetrahydroacridine (THA) has been reported to cause improvement in patients with senile dementia of the Alzheimer's type. We have examined some…”
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5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety by Villalobos, A, Butler, T W, Chapin, D S, Chen, Y L, DeMattos, S B, Ives, J L, Jones, S B, Liston, D R, Nagel, A A, Nason, D M

“…A series of N-benzylpiperidines (2a-d, 10) with novel isoxazole-containing tricycles has been prepared. This series has shown potent in vitro inhibition of the…”
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Design and Synthesis of 1-Heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one Derivatives as Potent, Selective Acetylcholinesterase Inhibitors by Nagel, Arthur A, Liston, Dane R, Jung, Stanley, Mahar, Melissa, Vincent, Lawrence A, Chapin, Douglas, Chen, Yuhpyng L, Hubbard, Sean, Ives, Jeffrey L

“…Herein is described the synthesis and structure--activity relationship of a novel series of aromatic and heteroaromatic 3-(1-benzyl-4-piperidinyl)propan-1-one…”
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Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase by Lowe, John A, Archer, Robert L, Chapin, Douglas S, Cheng, John B, Helweg, David, Johnson, Jonathan L, Koe, B. Kenneth, Lebel, Lorraine A, Moore, Peter F

“…A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase…”
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Sertraline, a serotonin-uptake inhibitor, reduces food intake and body weight in lean rats and genetically obese mice by Nielsen, JA, Chapin, DS, Johnson, JL, Torgersen, LK

“…Sertraline was found to inhibit weight gain and decrease food intake without affecting locomotion in rats and genetically obese (ob/ob) mice. Doses of 10,…”
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Calcium-independent phosphodiesterase inhibitors as putative antidepressants : [3-(bicycloakyloxy)-4-methoxyphenyl]-2-imidazolidinones by SACCOMANO, N. A, VINICK, F. J, LEBEL, L. A, RUSSO, L. L, HELWEG, D. A, JOHNSON, J. L, IVES, J. L, WILLIAMS, I. H, KOE, B. K, NIELSEN, J. A, WHALEN, W. M, MELTZ, M, PHILLIPS, D, THADIEO, P. F, JUNG, S, CHAPIN, D. S

“…The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also…”
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Behavioral and neurochemical effects of (-)- and (+/-)-cathinone: dose-response and time-course by Nielsen, J A, Schechter, M D

“…The purpose of the present study was to compare (-)-cathinone and its analogue (+/-)-cathinone using behavioral and neurochemical measures. Rats were trained…”
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Thyrotropin-releasing hormone and its analog MK-771 increase the cerebroventricular perfusate content of dihydroxyphenylacetic acid by Nielsen, J A, Moore, K E

“…The effects of thyrotropin-releasing hormone (TRH) and its synthetic analog, pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide (MK-771), were determined…”
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Central administration of prostaglandin E2 facilitates while F2 alpha attenuates acute dependence upon morphine rats by Nielsen, J A, Sparber, S B

“…The effects of prostaglandin D2 (PGD2), E2 (PGE2), and F2 alpha (PGF2 alpha) on acute dependence on morphine were investigated. Five mature, male Long-Evans…”
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Indomethacin facilitates acute tolerance to and dependence upon morphine as measured by changes in fixed-ratio behavior and rectal temperature in rats by Nielsen, J A, Sparber, S B

“…The effects of indomethacin, a prostaglandin (PG) synthetase inhibitor, on acute tolerance to and dependence on morphine were investigated. Twelve mature, male…”
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Indomethacin potentiates the operant behavior suppressant and rectal temperature lowering effects of low doses of d-amphetamine in rats by Nielsen, J A, Sparber, S B

“…Prostaglandins (PGs) may be important in modulating the actions of d-amphetamine. To test this hypothesis male rats were pretreated with indomethacin to…”
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A comparative study of the effects of prostaglandins and d-amphetamine on the metabolism of 3H-dopamine continuously presented to rat brain in vivo by Nielsen, J A, Sparber, S B

“…Unanesthetized rats with chronic indwelling cannulas, engaged in food reinforced operant behavior, were infused intracerebroventricularly with a solution…”
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d-Amphetamine antagonizes prostaglandin E1-induced hyperthermia and suppression of fixed interval operant behavior in rats by Nielsen, J A, Sparber, S B

“…The experiments reported herein were designed to study the effects of prostaglandin F2 alpha (PGF2 alpha) and PGE1 on operant behavior and rectal temperature…”
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Metabolism of 3H-dopamine continuously perfused through push-pull cannulas in rats' brains: modification by amphetamine or prostaglandin F2 alpha by Nielsen, J A, Fossom, L H, Sparber, S B

“…Using perfusion cannulas implanted in the lateral cerebroventricles, the metabolism of a trace concentration of 3H-dopamine, continuously presented, was…”
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