Search Results - "Nielsen, Jakob N."

The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading by JØRGENSEN, Sebastian B, NIELSEN, Jakob N, RICHTER, Erik A, WOJTASZEWSKI, Jørgen F. P, BIRK, Jesper B, OLSEN, Grith Skytte, VIOLLET, Benoit, ANDREELLI, Fabrizio, SCHJERLING, Peter, VAULONT, Sophie, HARDIE, D. Grahame, HANSEN, Bo F

“…The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading Sebastian B. Jørgensen 1 ,…”
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Dysregulation of Glycogen Synthase COOH- and NH2-Terminal Phosphorylation by Insulin in Obesity and Type 2 Diabetes Mellitus by Højlund, Kurt, Birk, Jesper B., Klein, Ditte K., Levin, Klaus, Rose, Adam J., Hansen, Bo F., Nielsen, Jakob N., Beck-Nielsen, Henning, Wojtaszewski, Jørgen F. P.

“…Context: Insulin-stimulated glucose disposal is impaired in obesity and type 2 diabetes mellitus (T2DM) and is tightly linked to impaired skeletal muscle…”
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Hexokinase 2, glycogen synthase and phosphorylase play a key role in muscle glycogen supercompensation by Irimia, José M, Rovira, Jordi, Nielsen, Jakob N, Guerrero, Mario, Wojtaszewski, Jørgen F P, Cussó, Roser

“…Glycogen-depleting exercise can lead to supercompensation of muscle glycogen stores, but the biochemical mechanisms of this phenomenon are still not completely…”
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Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender by Kiens, Bente, Roepstorff, Carsten, Glatz, Jan F. C, Bonen, Arend, Schjerling, Peter, Knudsen, Jens, Nielsen, Jakob N

“…1 Department of Human Physiology, The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, DK-2100…”
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Invited review: effect of acute exercise on insulin signaling and action in humans by Wojtaszewski, Jørgen F P, Nielsen, Jakob N, Richter, Erik A

“…After a single bout of exercise, insulin action is increased in the muscles that were active during exercise. The increased insulin action has been shown to…”
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5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle by Nielsen, Jakob N, Mustard, Kirsty J. W, Graham, Drew A, Yu, Haiyan, MacDonald, Christopher S, Pilegaard, Henriette, Goodyear, Laurie J, Hardie, D. Grahame, Richter, Erik A, Wojtaszewski, Jorgen F. P

“…1  Institute of Exercise and Sport Sciences and 4  August Krogh Institute, Copenhagen Muscle Research Centre, University of Copenhagen, DK-2100 Copenhagen,…”
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Phosphorylation-dependent Translocation of Glycogen Synthase to a Novel Structure during Glycogen Resynthesis by Prats, Clara, Cadefau, Joan A, Cussó, Roser, Qvortrup, Klaus, Nielsen, Jakob N, Wojtaszewski, Jørgen F P, Wojtaszewki, Jørgen F P, Hardie, D Grahame, Stewart, Greg, Hansen, Bo F, Ploug, Thorkil

“…Glycogen metabolism has been the subject of extensive research, but the mechanisms by which it is regulated are still not fully understood. It is well accepted…”
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Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise by Roepstorff, Carsten, Vistisen, Bodil, Donsmark, Morten, Nielsen, Jakob N., Galbo, Henrik, Green, Kevin A., Hardie, D. Grahame, Wojtaszewski, Jørgen F. P., Richter, Erik A., Kiens, Bente

“…Hormone-sensitive lipase (HSL) catalyses the hydrolysis of myocellular triacylglycerol (MCTG), which is a potential energy source during exercise. Therefore,…”
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Population pharmacokinetic model for human growth hormone in adult patients in chronic dialysis compared with healthy subjects by Klitgaard, Thomas, Nielsen, Jakob N, Skettrup, Mia P, Harper, Angela, Lange, Martin

“…Abstract Objective To develop a population pharmacokinetic (PK) model of recombinant human growth hormone (rhGH) treatment in patients with end-stage renal…”
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Regulation of glycogen synthase activity and phosphorylation by exercise by Nielsen, Jakob N., Wojtaszewski, Jørgen F. P.

“…Glycogen synthase (GS) catalyses the rate-limiting step of UDP-glucose incorporation into glycogen. Exercise is a potent regulator of GS activity, leading to…”
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Pharmacokinetics and pharmacodynamics of growth hormone in patients on chronic haemodialysis compared with matched healthy subjects: an open, nonrandomized, parallel-group trial by Langbakke, Irene H., Nielsen, Jakob N., Skettrup, Mia P., Harper, Angela, Klitgaard, Thomas, Weil, Angelika, Engelhardt, Eva, Lange, Martin

“…Summary Background  GH may be beneficial in treating patients with end‐stage renal disease (ESRD). However, the efficacy and safety of GH could be compromised…”
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Role of 5′AMP‐activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease by Nielsen, Jakob N., Wojtaszewski, Jørgen F. P., Haller, Ronald G., Hardie, D. Grahame, Kemp, Bruce E., Richter, Erik A., Vissing, John

“…It has been suggested that 5′AMP‐activated protein kinase (AMPK) is involved in the regulation of glucose and glycogen metabolism in skeletal muscle. We used…”
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Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity by Andersson, Ulrika, Treebak, Jonas T., Nielsen, Jakob N., Smith, Kirsty L., Abbott, Caroline R., Small, Caroline J., Carling, David, Richter, Erik A.

“…Recent studies have demonstrated that AMP-activated protein kinase (AMPK) in the hypothalamus is involved in the regulation of food intake. Because exercise is…”
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Exercise signalling to glucose transport in skeletal muscle by Richter, Erik A., Nielsen, Jakob N., Jørgensen, Sebastian B., Frøsig, Christian, Birk, Jesper B., Wojtaszewski, Jørgen F. P.

“…Contraction-induced glucose uptake in skeletal muscle is mediated by an insulin-independent mechanism that leads to translocation of the GLUT4 glucose…”
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Increased atypical PKC activity in endurance-trained human skeletal muscle by Nielsen, Jakob N, Frøsig, Christian, Sajan, Mini P, Miura, Atsushi, Standaert, Mary L, Graham, Drew A, Wojtaszewski, Jørgen F.P, Farese, Robert V, Richter, Erik A

“…Exercise training may modulate protein content and enzyme activities in skeletal muscle. However, it is not known whether atypical protein kinase C (aPKC) is…”
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Decreased insulin action in skeletal muscle from patients with McArdle's disease by Nielsen, Jakob N, Vissing, John, Wojtaszewski, Jørgen F P, Haller, Ronald G, Begum, Najma, Richter, Erik A

“…Insulin action is decreased by high muscle glycogen concentrations in skeletal muscle. Patients with McArdle's disease have chronic high muscle glycogen levels…”
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GLUT-4 translocation in skeletal muscle studied with a cell-free assay: involvement of phospholipase D by Kristiansen, S, Nielsen, J N, Bourgoin, S, Klip, A, Franco, M, Richter, E A

“…GLUT-4-containing membranes immunoprecipitated from insulin-stimulated rat skeletal muscle produce the phospholipase D (PLD) product phosphatidic acid. In…”
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Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Effect of acute exercise on insulin signaling and action in humans by Wojtaszewski, Jorgen F. P, Nielsen, Jakob N, Richter, Erik A

“…Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen…”
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Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training by DAUGAARD, J. R, NIELSEN, J. N, KRISTIANSEN, S, ANDERSEN, J. L, HARGREAVES, M, RICHTER, E. A

“…Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training. J R Daugaard , J N Nielsen , S Kristiansen , J L Andersen , M…”
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Regulation of hormone-sensitive lipase activity and Ser super(563) and Ser super(565) phosphorylation in human skeletal muscle during exercise by Roepstorff, Carsten, Vistisen, Bodil, Donsmark, Morten, Nielsen, Jakob N, Galbo, Henrik, Green, Kevin A, Hardie, DGrahame, Wojtaszewski, Joergen FP, Richter, Erik A, Kiens, Bente

“…Hormone-sensitive lipase (HSL) catalyses the hydrolysis of myocellular triacylglycerol (MCTG), which is a potential energy source during exercise. Therefore,…”
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