Search Results - "Nielsen, Jakob B."

A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi by Nødvig, Christina S, Nielsen, Jakob B, Kogle, Martin E, Mortensen, Uffe H

“…The number of fully sequenced fungal genomes is rapidly increasing. Since genetic tools are poorly developed for most filamentous fungi, it is currently…”
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Accurate prediction of secondary metabolite gene clusters in filamentous fungi by Andersen, Mikael R, Nielsen, Jakob B, Klitgaard, Andreas, Petersen, Lene M, Zachariasen, Mia, Hansen, Tilde J, Blicher, Lene H, Gotfredsen, Charlotte H, Larsen, Thomas O, Nielsen, Kristian F, Mortensen, Uffe H

“…Biosynthetic pathways of secondary metabolites from fungi are currently subject to an intense effort to elucidate the genetic basis for these compounds due to…”
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Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization by Klitgaard, Andreas, Nielsen, Jakob B, Frandsen, Rasmus J. N, Andersen, Mikael R, Nielsen, Kristian F

“…Filamentous fungi are a rich source of bioactive compounds, ranging from statins over immunosuppressants to antibiotics. The coupling of genes to metabolites…”
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Versatile Enzyme Expression and Characterization System for Aspergillus nidulans, with the Penicillium brevicompactum Polyketide Synthase Gene from the Mycophenolic Acid Gene Cluster as a Test Case by HANSEN, Bjarne G, SALOMONSEN, Bo, NIELSEN, Morten T, NIELSEN, Jakob B, HANSEN, Niels B, NIELSEN, Kristian F, REGUEIRA, Torsten B, NIELSEN, Jens, PATIL, Kiran R, MORTENSEN, Uffe H

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi by Hansen, Bjarne G, Genee, Hans J, Kaas, Christian S, Nielsen, Jakob B, Regueira, Torsten B, Mortensen, Uffe H, Frisvad, Jens C, Patil, Kiran R

“…Many secondary metabolites produced by filamentous fungi have potent biological activities, to which the producer organism must be resistant. An example of…”
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Adaptive evolution of drug targets in producer and non-producer organisms by Hansen, Bjarne G, Sun, Xin E, Genee, Hans J, Kaas, Christian S, Nielsen, Jakob B, Mortensen, Uffe H, Frisvad, Jens C, Hedstrom, Lizbeth

“…MPA (mycophenolic acid) is an immunosuppressive drug produced by several fungi in Penicillium subgenus Penicillium. This toxic metabolite is an inhibitor of…”
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Transient disruption of non-homologous end-joining facilitates targeted genome manipulations in the filamentous fungus Aspergillus nidulans by Nielsen, Jakob B., Nielsen, Michael L., Mortensen, Uffe H.

“…We have developed a transiently disrupted nkuA system in Aspergillus nidulans for efficient gene targeting. The nkuA disruption was made by inserting a…”
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A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans by NIELSEN, Michael L, NIELSEN, Jakob B, RANK, Christian, KLEJNSTRUP, Marie L, HOLM, Dorte K, BROGAARD, Katrine H, HANSEN, Bjarne G, FRISVAD, Jens C, LARSEN, Thomas O, MORTENSEN, Uffe H

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Genetics of Polyketide Metabolism in Aspergillus nidulans by Klejnstrup, Marie L, Frandsen, Rasmus J N, Holm, Dorte K, Nielsen, Morten T, Mortensen, Uffe H, Larsen, Thomas O, Nielsen, Jakob B

“…Secondary metabolites are small molecules that show large structural diversity and a broad range of bioactivities. Some metabolites are attractive as drugs or…”
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A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans by Nielsen, Michael L., Nielsen, Jakob B., Rank, Christian, Klejnstrup, Marie L., Holm, Dorte K., Brogaard, Katrine H., Hansen, Bjarne G., Frisvad, Jens C., Larsen, Thomas O., Mortensen, Uffe H.

“…Abstract Fungi possess an advanced secondary metabolism that is regulated and coordinated in a complex manner depending on environmental challenges. To…”
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Supercluster takes a walk on the wild side by Nielsen, Jakob B, Andersen, Mikael R, Mortensen, Uffe H

“…In a recent Proc. Natl. Acad. Sci. USA paper by Wiemann et al. , a gene supercluster for secondary metabolite production in Aspergillus fumigatus is…”
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Efficient PCR-based gene targeting with a recyclable marker for Aspergillus nidulans by Nielsen, Michael L., Albertsen, Line, Lettier, Gaëlle, Nielsen, Jakob B., Mortensen, Uffe H.

“…The rapid accumulation of genomic sequences from a large number of eukaryotes, including numerous filamentous fungi, has created a tremendous scientific…”
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Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88 by Andersen, M.R, Salazar, M.P, Schaap, P.J

“…The filamentous fungus Aspergillus niger exhibits great diversity in its phenotype. It is found globally, both as marine and terrestrial strains, produces both…”
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Accurate prediction of secondary metabolite gene clusters in filamentous fungi by Andersen, Mikael R., Nielsen, Jakob B., Klitgaard, Andreas, Petersen, Lene M., Zachariasen, Mia, Hansen, Tilde J., Blicher, Lene H., Gotfredsen, Charlotte H., Larsen, Thomas O., Nielsen, Kristian F., Mortensen, Uffe H.

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A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi: e0133085 by Noedvig, Christina S, Nielsen, Jakob B, Kogle, Martin E, Mortensen, Uffe H

“…The number of fully sequenced fungal genomes is rapidly increasing. Since genetic tools are poorly developed for most filamentous fungi, it is currently…”
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A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans: Genome-wide PKS gene deletion library in A. nidulans by Nielsen, Michael L., Nielsen, Jakob B., Rank, Christian, Klejnstrup, Marie L., Holm, Dorte K., Brogaard, Katrine H., Hansen, Bjarne G., Frisvad, Jens C., Larsen, Thomas O., Mortensen, Uffe H.

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