Search Results - "Nielsen, Henrietta"

α-synuclein in the pathophysiology of Alzheimer's disease by Twohig, Daniel, Nielsen, Henrietta M

“…The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles…”
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Complement in the brain by Veerhuis, Robert, Nielsen, Henrietta M., Tenner, Andrea J.

“…► Complement (C), a powerful tool of innate immunity, is important for defense of the brain. ► Most C proteins can be synthesized in the brain, mainly by glia…”
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Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment by Lindqvist, Daniel, Hall, Sara, Surova, Yulia, Nielsen, Henrietta M, Janelidze, Shorena, Brundin, Lena, Hansson, Oskar

“…Highlight • High levels of inflammatory markers in cerebrospinal fluid were associated with fatigue, depression, and cognitive impairment in patients with…”
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The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer's but Not Parkinson's Disease or Dementia with Lewy Bodies by Wennström, Malin, Surova, Yulia, Hall, Sara, Nilsson, Christer, Minthon, Lennart, Hansson, Oskar, Nielsen, Henrietta M

“…A major difference in the revised diagnostic criteria for Alzheimer's disease (AD) is the incorporation of biomarkers to support a clinical diagnosis and allow…”
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Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy by Wennström, Malin, Surova, Yulia, Hall, Sara, Nilsson, Christer, Minthon, Lennart, Boström, Fredrik, Hansson, Oskar, Nielsen, Henrietta M

“…Neurosin is a protease that in vitro degrades α-synuclein, the main constituent of Lewy bodies found in brains of patients with synucleinopathy including…”
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Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer’s disease patients and controls by Martínez-Morillo, Eduardo, Hansson, Oskar, Atagi, Yuka, Bu, Guojun, Minthon, Lennart, Diamandis, Eleftherios P., Nielsen, Henrietta M.

“…The apolipoprotein E (ApoE) ε4 allele is the strongest risk factor of sporadic Alzheimer’s disease (AD), however, the fluid concentrations of ApoE and its…”
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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases by Fernández-Calle, Rosalía, Konings, Sabine C, Frontiñán-Rubio, Javier, García-Revilla, Juan, Camprubí-Ferrer, Lluís, Svensson, Martina, Martinson, Isak, Boza-Serrano, Antonio, Venero, José Luís, Nielsen, Henrietta M, Gouras, Gunnar K, Deierborg, Tomas

“…ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of…”
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APOE genotype dictates lipidomic signatures in primary human hepatocytes by Almeida, Francisco C., Patra, Kalicharan, Giannisis, Andreas, Niesnerova, Anezka, Nandakumar, Renu, Ellis, Ewa, Oliveira, Tiago Gil, Nielsen, Henrietta M.

“…Apolipoprotein E (APOE) genetic variants are most notably known for their divergent impact on the risk of developing Alzheimer’s disease. While APOE genotype…”
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CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease by Westin, Karin, Buchhave, Peder, Nielsen, Henrietta, Minthon, Lennart, Janciauskiene, Sabina, Hansson, Oskar

“…Chemokine (C-C motif) receptor 2 (CCR2)-signaling can mediate accumulation of microglia at sites affected by neuroinflammation. CCR2 and its main ligand CCL2…”
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Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2 by Schultz, Nina, Nielsen, Henrietta M, Minthon, Lennart, Wennström, Malin

“…ABSTRACTDeposition of amyloid-β (Aβ) 1–42, the major component of senile plaques characteristic of Alzheimer disease, affects brain microvascular integrity and…”
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Altered CSF orexin and α-synuclein levels in dementia patients by Wennström, Malin, Londos, Elisabet, Minthon, Lennart, Nielsen, Henrietta M

“…Neurodegenerative dementia, most frequently represented by Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), is often accompanied by altered…”
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The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes by Mulder, Sandra D., Veerhuis, Robert, Blankenstein, Marinus A., Nielsen, Henrietta M.

“…Astrocytes appear to be important mediators in the clearance of amyloid beta1-42 (Aβ), the key component of senile plaques characteristic of Alzheimer's…”
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Behavioral and cognitive performance of humanized APOEε3/ε3 liver mice in relation to plasma apolipoprotein E levels by Kessler, Kat, Giannisis, Andreas, Bial, Greg, Foquet, Lander, Nielsen, Henrietta M., Raber, Jacob

“…Plasma apolipoprotein E levels were previously associated with the risk of developing Alzheimer’s disease (AD), levels of cerebrospinal fluid AD biomarkers,…”
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Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro by Mulder, Sandra D., Nielsen, Henrietta M., Blankenstein, Marinus A., Eikelenboom, Piet, Veerhuis, Robert

“…Defective clearance of the amyloid‐β peptide (Aβ) from the brain is considered a strong promoter in Alzheimer's disease (AD) pathogenesis. Astrocytes and…”
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Amyloid‐beta 1‐40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro by Schultz, Nina, Brännström, Kristoffer, Byman, Elin, Moussaud, Simon, Nielsen, Henrietta M., Olofsson, Anders, Wennström, Malin

“…Summary The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in…”
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Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice by Giannisis, Andreas, Patra, Kalicharan, Edlund, Anna K., Nieto, Lur Agirrezabala, Benedicto-Gras, Joan, Moussaud, Simon, de la Rosa, Andrés, Twohig, Daniel, Bengtsson, Tore, Fu, Yuan, Bu, Guojun, Bial, Greg, Foquet, Lander, Hammarstedt, Christina, Strom, Stephen, Kannisto, Kristina, Raber, Jacob, Ellis, Ewa, Nielsen, Henrietta M.

“…Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer’s disease (AD) risk and AD biomarker levels…”
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Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway by Zhao, Jing, Fu, Yuan, Liu, Chia-Chen, Shinohara, Mitsuru, Nielsen, Henrietta M., Dong, Qiang, Kanekiyo, Takahisa, Bu, Guojun

“…Apolipoprotein E (apoE) is the major cholesterol transport protein in the brain. Among the three human APOE alleles (APOE2, APOE3, and APOE4), APOE4 is the…”
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Assessment of Peptide Chemical Modifications on the Development of an Accurate and Precise Multiplex Selected Reaction Monitoring Assay for Apolipoprotein E Isoforms by Martínez-Morillo, Eduardo, Nielsen, Henrietta M, Batruch, Ihor, Drabovich, Andrei P, Begcevic, Ilijana, Lopez, Mary F, Minthon, Lennart, Bu, Guojun, Mattsson, Niklas, Portelius, Erik, Hansson, Oskar, Diamandis, Eleftherios P

“…Apolipoprotein E (ApoE) is a polymorphic protein that plays a major role in lipid metabolism in the central nervous system and periphery. It has three common…”
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Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer's disease by Giannisis, Andreas, Al-Grety, Asma, Carlsson, Henrik, Patra, Kalicharan, Twohig, Daniel, Sando, Sigrid Botne, Lauridsen, Camilla, Berge, Guro, Grøntvedt, Gøril Rolfseng, Bråthen, Geir, White, Linda R, Kultima, Kim, Nielsen, Henrietta M

“…Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer's disease (AD). Although the…”
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Associations Between APOE Variants, Tau and α-Synuclein by Rodriguez-Vieitez, Elena, Nielsen, Henrietta M

“…Neurodegenerative diseases are characterized by the aggregation and deposition of misfolded proteins in the brain, most prominently amyloid-β (Aβ), tau and…”
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