Involvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertia

Involvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertia

An altered oxytocin and progesterone receptor (OXTR and PGR, respectively) expression was postulated in canine uterine inertia (UI), which is the lack of functional myometrial contractions. OXTR and PGR expressions were compared in uterine tissue obtained during C-section due to primary UI (PUI; n =...

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Published in:International journal of molecular sciences Vol. 23; no. 21; p. 13601
Main Authors: Jungmann, Carolin, Houghton, Caroline Gauguin, Nielsen, Frederik Goth, Packeiser, Eva-Maria, Körber, Hanna, Reichler, Iris M., Balogh, Orsolya, Goericke-Pesch, Sandra
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-11-2022
MDPI
Subjects:
Cesarean section
Desensitization
dog
dystocia
Etiology
Fetuses
Gene expression
Immunohistochemistry
Kinases
Medical treatment
Myometrium
Oxytocin
oxytocin receptor
Pathophysiology
Placenta
Pregnancy
Progesterone
progesterone receptor
Proteins
Smooth muscle
Statistical analysis
uterine inertia
Uterus
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Summary:An altered oxytocin and progesterone receptor (OXTR and PGR, respectively) expression was postulated in canine uterine inertia (UI), which is the lack of functional myometrial contractions. OXTR and PGR expressions were compared in uterine tissue obtained during C-section due to primary UI (PUI; n = 12) and obstructive dystocia (OD, n = 8). In PUI, the influence of litter size was studied (small/normal/large litter: PUI-S/N/L: n = 5/4/3). Staining intensity in immunohistochemistry was scored for the longitudinal and circular myometrial layer and summarized per dog (IP-Myoscore). Mean P4 did not differ significantly between PUI (n = 9) and OD (n = 7). OXTR and PGR expressions (ratios) were significantly higher in PUI (OXTR: p = 0.0019; PGR: p = 0.0339), also for OXTR in PUI-N versus OD (p = 0.0034). A trend for a higher PGR IP-Myoscore was identified (PUI-N vs. OD, p = 0.0626) as well as an influence of litter size (lowest PGR-Myoscore in PUI-L, p = 0.0391). In conclusion, PUI was not related to higher P4, but potentially increased PGR availability compared to OD. It remains to be clarified whether OXTR is upregulated in PUI due to a counterregulatory mechanism to overcome myometrial quiescence or downregulated in OD due to physiological slow OXTR desensitization associated with an advanced duration of labor. Identified OXTR differences between myometrial layers indicate the need for further research.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232113601