Search Results - "Nielsen, Elsebet Ø"

Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism by Shahsavar, Azadeh, Kastrup, Jette S, Nielsen, Elsebet Ø, Kristensen, Jesper L, Gajhede, Michael, Balle, Thomas

“…Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that belong to the Cys-loop receptor superfamily. These receptors are…”
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Ligands for Glutamate Receptors:  Design and Therapeutic Prospects by Bräuner-Osborne, Hans, Egebjerg, Jan, Nielsen, Elsebet Ø, Madsen, Ulf, Krogsgaard-Larsen, Povl

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GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment by Vinkers, Christiaan H, van Oorschot, Ruud, Nielsen, Elsebet Ø, Cook, James M, Hansen, Henrik H, Groenink, Lucianne, Olivier, Berend, Mirza, Naheed R

“…Within the GABA(A)-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be…”
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The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies by Vinkers, Christiaan H., Korte-Bouws, Gerdien A. H., Sastre Toraño, Javier, Mirza, Naheed R., Nielsen, Elsebet Ø., Ahring, Philip K., de Jong, Gerhardus J., Olivier, Berend

“…Background In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is…”
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Combined α7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: A comparison of SSR180711 and PNU-282987 by Andreasen, Jesper T., Redrobe, John P., Nielsen, Elsebet Ø.

“…Emerging evidence points to an involvement of nicotinic acetylcholine receptors (nAChRs) in major depression. Nicotine improves symptoms of depression in…”
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Synthesis and Structure−Activity Relationship Studies of 2-(N-Substituted)-aminobenzimidazoles as Potent Negative Gating Modulators of Small Conductance Ca2+-Activated K+ Channels by Sørensen, Ulrik S, Strøbæk, Dorte, Christophersen, Palle, Hougaard, Charlotte, Jensen, Marianne L, Nielsen, Elsebet Ø, Peters, Dan, Teuber, Lene

“…Small conductance Ca2+-activated K+ channels (SK channels) participate in the control of neuronal excitability, in the shaping of action potential firing…”
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GABAA Receptor α Subunits Differentially Contribute to Diazepam Tolerance after Chronic Treatment by Vinkers, Christiaan H., van Oorschot, Ruud, Nielsen, Elsebet Ø., Cook, James M., Hansen, Henrik H., Groenink, Lucianne, Olivier, Berend, Mirza, Naheed R.

“…Background Within the GABAA-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can…”
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Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4–α4 interface by Ahring, Philip K., Olsen, Jeppe A., Nielsen, Elsebet Ø., Peters, Dan, Pedersen, Martin H.F., Rohde, Line A., Kastrup, Jette S., Shahsavar, Azadeh, Indurthi, Dinesh C., Chebib, Mary, Gajhede, Michael, Balle, Thomas

“…The nicotinic acetylcholine receptor α4β2 is important for normal mammalian brain function and is known to express in two different stoichiometries, (α4)2(β2)3…”
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A combined α7 nicotinic acetylcholine receptor agonist and monoamine reuptake inhibitor, NS9775, represents a novel profile with potential benefits in emotional and cognitive disturbances by Andreasen, Jesper T., Redrobe, John P., Nielsen, Elsebet Ø., Christensen, Jeppe K., Olsen, Gunnar M., Peters, Dan

“…As affective and cognitive disturbances frequently co-occur in psychiatric disorders, research into opportunities to simultaneously target both entities is…”
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Molecular Determinants of Subtype-selective Efficacies of Cytisine and the Novel Compound NS3861 at Heteromeric Nicotinic Acetylcholine Receptors by Harpsøe, Kasper, Hald, Helle, Timmermann, Daniel B., Jensen, Marianne L., Dyhring, Tino, Nielsen, Elsebet Ø., Peters, Dan, Balle, Thomas, Gajhede, Michael, Kastrup, Jette S., Ahring, Philip K.

“…Deciphering which specific agonist-receptor interactions affect efficacy levels is of high importance, because this will ultimately aid in designing selective…”
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Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons by Strøbaek, Dorte, Hougaard, Charlotte, Johansen, Tina H, Sørensen, Ulrik S, Nielsen, Elsebet Ø, Nielsen, Karin S, Taylor, Ruth D T, Pedarzani, Paola, Christophersen, Palle

“…SK channels are small conductance Ca(2+)-activated K(+) channels important for the control of neuronal excitability, the fine tuning of firing patterns, and…”
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Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test by Andreasen, Jesper T., Nielsen, Elsebet Ø., Redrobe, John P.

“…Introduction Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases…”
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Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan by Jacobsen, Jacob P. R., Nielsen, Elsebet Ø., Hummel, Rene, Redrobe, John Paul, Mirza, Naheed, Weikop, Pia

“…Rationale Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of…”
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Delineation of an endogenous zinc-binding site in the human dopamine transporter by Norregaard, Lene, Frederiksen, Dorte, Nielsen, Elsebet Ø., Gether, Ulrik

“…The molecular basis for substrate translocation in the Na+/Cl−‐dependent neurotransmitter transporters remains elusive. Here we report novel insight into the…”
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Bioisosteric Modifications of 2-Arylureidobenzoic Acids:  Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5 by Valgeirsson, Jon, Nielsen, Elsebet Ø, Peters, Dan, Mathiesen, Claus, Kristensen, Anders S, Madsen, Ulf

“…2-Arylureidobenzoic acids (AUBAs) have recently been presented as the first series of selective noncompetitive GluR5 antagonists. In this paper we have…”
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The nicotinic α7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-β1–42 by Søderman, Andreas, Thomsen, Morten S, Hansen, Henrik H, Nielsen, Elsebet Ø, Jensen, Morten S, West, Mark J, Mikkelsen, Jens D

“…Abstract Recent studies have demonstrated that amyloid-β1–42 (Aβ1–42 ) binds to the nicotinergic α7 acetylcholine receptor (α7 nAChR) and that the application…”
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CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate by Herrik, Kjartan F, Redrobe, John P, Holst, Dorte, Hougaard, Charlotte, Sandager-Nielsen, Karin, Nielsen, Alexander N, Ji, Huifang, Holst, Nina M, Rasmussen, Hanne B, Nielsen, Elsebet Ø, Strøbæk, Dorte, Shepard, Paul D, Christophersen, Palle

“…Dopamine (DA) containing midbrain neurons play critical roles in several psychiatric and neurological diseases, including schizophrenia and attention deficit…”
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The novel compound (±)-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined μ-opioid receptor agonist and monoamine reuptake inhibitor tramadol by Munro, Gordon, Bæk, Camilla Æ., Erichsen, Helle K., Nielsen, Alexander N., Nielsen, Elsebet Ø., Scheel-Kruger, Jørgen, Weikop, Pia, Peters, Dan

“…Tramadol is an atypical analgesic with a unique dual mechanism of action. It acts on monoamine transporters to inhibit reuptake of noradrenaline (NA) and…”
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[11 C]NS8880, a promising PET radiotracer targeting the norepinephrine transporter by Vase, Karina H, Peters, Dan, Nielsen, Elsebet Ø, Alstrup, Aage K.O, Bender, Dirk

“…Abstract Introduction Positron emission tomography (PET) imaging of the norepinephrine transporter (NET) is still hindered by the availability of useful PET…”
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The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D 2 receptor antagonism and fast receptor dissociation properties by Dyhring, Tino, Nielsen, Elsebet Ø., Sonesson, Clas, Pettersson, Fredrik, Karlsson, Jonas, Svensson, Peder, Christophersen, Palle, Waters, Nicholas

“…A new pharmacological class of CNS ligands with the unique ability to stimulate or suppress motor and behavioral symptoms depending on the prevailing…”
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