Search Results - "Nielsen, Carsten K"

The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration by Srinivasan, Subhashini, Simms, Jeffrey A, Nielsen, Carsten K, Lieske, Steven P, Bito-Onon, Jade J, Yi, Henry, Hopf, Frederic Woodward, Bonci, Antonello, Bartlett, Selena E

“…Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor…”
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Fiber laser-based light source for coherent anti-Stokes Raman scattering microspectroscopy by Andresen, Esben R, Nielsen, Carsten K, Thøgersen, Jan, Keiding, Søren R

“…We demonstrate an alternative light source for CARS microspectroscopy based on a fiber laser and a photonic-crystal fiber. The light source simultaneously…”
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Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein by Haass-Koffler, Carolina L., Francis, T. Chase, Gandhi, Pauravi, Patel, Reesha, Naemuddin, Mohammad, Nielsen, Carsten K., Bartlett, Selena E., Bonci, Antonello, Vasile, Stefan, Hood, Becky L., Suyama, Eigo, Hedrick, Michael P., Smith, Layton H., Limpert, Allison S., Roberto, Marisa, Cosford, Nicholas D.P., Sheffler, Douglas J.

“…Stress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRF1 and CRF2), and the CRF-binding protein (CRFBP)…”
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The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol by Steensland, Pia, Simms, Jeffrey A, Nielsen, Carsten K, Holgate, Joan, Bito-Onon, Jade J, Bartlett, Selena E

“…The current obesity epidemic is thought to be partly driven by over-consumption of sugar-sweetened diets and soft drinks. Loss-of-control over eating and…”
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Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration by Smith, Maree T, Edwards, Stephen R, Nielsen, Carsten K

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Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395 by Simms, Jeffrey A., Nielsen, Carsten K., Li, Rui, Bartlett, Selena E.

“…Corticotrophin‐releasing factor (CRF) is a mediator of stress responses and a key modulator of ethanol‐mediated behaviors. We report here that the CRF receptor…”
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Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain by Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R., Smith, Maree T.

“…Previously, we reported that oxycodone is a putative κ-opioid agonist based on studies where intracerebroventricular (i.c.v.) pre-treatment of rats with the…”
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δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats by Nielsen, Carsten K, Simms, Jeffrey A, Li, Rui, Mill, Douglas, Yi, Henry, Feduccia, Allison A, Santos, Nathan, Bartlett, Selena E

“…Binge-like patterns of excessive drinking during young adulthood increase the propensity for alcohol use disorders (AUDs) later in adult life; however, the…”
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χ-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain by Brust, Andreas, Palant, Elka, Croker, Daniel E, Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I, Wilson, David, Nielsen, Carsten K, Smith, Maree T, Alewood, Dianne, Alewood, Paul F, Lewis, Richard J

“…Norepinephrine (NE) amplifies the strength of descending pain inhibition, giving inhibitors of spinal NET clinical utility in the management of pain. χ-MrIA…”
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Cabergoline Decreases Alcohol Drinking and Seeking Behaviors Via Glial Cell Line-Derived Neurotrophic Factor by Carnicella, Sebastien, Ahmadiantehrani, Somayeh, He, Dao-Yao, Nielsen, Carsten K, Bartlett, Selena E, Janak, Patricia H, Ron, Dorit

“…Background Cabergoline is an ergotamine derivative that increases the expression of glial cell line-derived neurotrophic factor (GDNF) in vitro. We recently…”
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Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence by Kim, Joseph A., Bartlett, Selena, He, Li, Nielsen, Carsten K., Chang, Amy M., Kharazia, Viktor, Waldhoer, Maria, Ou, Chrissi J., Taylor, Stacy, Ferwerda, Madeline, Cado, Dragana, Whistler, Jennifer L.

“…Opioid drugs, such as morphine, are among the most effective analgesics available. However, their utility for the treatment of chronic pain is limited by side…”
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A Novel Delta Opioid Receptor Antagonist, SoRI-9409, Produces a Selective and Long-Lasting Decrease in Ethanol Consumption in Heavy-Drinking Rats by Nielsen, Carsten K, Simms, Jeffrey A, Pierson, Haley B, Li, Rui, Saini, Surendra K, Ananthan, Subramaniam, Bartlett, Selena E

“…Background Naltrexone, a compound with high affinity for the μ opioid receptor (MOP-R) reduces alcohol consumption. SoRI-9409 is a derivative of naltrexone…”
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The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking by Nielsen, Carsten K., Simms, Jeffrey A., Bito-Onon, Jade J., Li, Rui, Ananthan, Subramaniam, Bartlett, Selena E.

“…ABSTRACT A major problem in treating alcohol use disorders (AUDs) is the high rate of relapse due to stress and re‐exposure to cues or an environment…”
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A chimeric approach to evaluate the role of corticotropin releasing factor in alcohol use disorder by Haass-Koffler, Carolina L, Henry, Andrea T, Melkus, Gerd, Simms, Jeffrey A, Naemmuddin, Mohammed, Nielsen, Carsten K, Lasek, Amy W, Magill, Molly, Schwandt, Melanie L, Momenan, Reza, Hodgkinson, Colin A, Bartlett, Selena E, Swift, Robert M, Bonci, Antonello, Leggio, Lorenzo

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Anti-allodynic efficacy of the χ-conopeptide, Xen2174, in rats with neuropathic pain by Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L., McCumber, Damon, Smith, Maree T.

“…Xen2174 is a structural analogue of Mr1A, a χ-conopeptide recently isolated from the venom of the marine cone snail, Conus marmoreus. Although both…”
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Optimal economic institutions under rational overconfidence, with applications to the choice of exchange rate regime by Nielsen, Carsten K.

“…We study the optimal choice of exchange rate regime when agents have beliefs that are mutually inconsistent. A general framework for identifying optimal…”
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Systemic Coadministration of Chloramphenicol with Intravenous but not Intracerebroventricular Morphine Markedly Increases Morphine Antinociception and Delays Development of Antinociceptive Tolerance in Rats by Smith, M T, Nielsen, C K, Lim-Fraser, MYC, Wright, AWE, Lau, M

“…Chloramphenicol, an in vitro inhibitor of the glucuronidation of morphine to its putative antianalgesic metabolite, morphine-3-glucuronide (M3G), was…”
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Continuous-wave wavelength conversion in a photonic crystal fiber with two zero-dispersion wavelengths by Andersen, Thomas, Hilligsøe, Karen, Nielsen, Carsten, Thøgersen, Jan, Hansen, K, Keiding, Søren, Larsen, Jakob

“…We demonstrate continuous-wave wavelength conversion through four-wave mixing in an endlessly single mode photonic crystal fiber. Phasematching is possible at…”
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Morphine-induced endocytosis of the mu opioid receptor in a novel knock in mouse enhances analgesia and reduces tolerance and dependence by Kim, Joseph A., Bartlett, Selena, He, Li, Nielsen, Carsten K., Chang, Amy M., Kharazia, Viktor, Waldhoer, Maria, Ou, Chrissi J., Taylor, Stacy, Ferwerda, Madeline, Cado, Dragana, Whistler, Jennifer L.

“…Chronic pain remains one of the most widespread and under treated medical conditions. Opioid drugs, such as morphine, are some of the most effective analgesics…”
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Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat by Nielsen, C K, Ross, F B, Smith, M T

“…Our previous studies indicate that oxycodone is a putative kappa-opioid agonist, whereas morphine is a well documented micro-opioid agonist. Because there is…”
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