Search Results - "Niehrs, Annika"

Regulation of NK-Cell Function by HLA Class II by Niehrs, Annika, Altfeld, Marcus

“…Natural Killer (NK) cells were initially described as part of the innate immune system and characterized by their ability to lyse malignant and virus-infected…”
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A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44 by Niehrs, Annika, Garcia-Beltran, Wilfredo F., Norman, Paul J., Watson, Gabrielle M., Hölzemer, Angelique, Chapel, Anaïs, Richert, Laura, Pommerening-Röser, Andreas, Körner, Christian, Ozawa, Mikki, Martrus, Glòria, Rossjohn, Jamie, Lee, Jar-How, Berry, Richard, Carrington, Mary, Altfeld, Marcus

“…Natural killer (NK) cells can recognize virus-infected and stressed cells 1 using activating and inhibitory receptors, many of which interact with HLA class I…”
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HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells by Fittje, Pia, Hœlzemer, Angelique, Garcia-Beltran, Wilfredo F., Vollmers, Sarah, Niehrs, Annika, Hagemann, Kerri, Martrus, Glòria, Körner, Christian, Kirchhoff, Frank, Sauter, Daniel, Altfeld, Marcus

“…Antiviral NK cell activity is regulated through the interaction of activating and inhibitory NK cell receptors with their ligands on infected cells. HLA class…”
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Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C by Vollmers, Sarah, Lobermeyer, Annabelle, Niehrs, Annika, Fittje, Pia, Indenbirken, Daniela, Nakel, Jacqueline, Virdi, Sanamjeet, Brias, Sebastien, Trenkner, Timo, Sauer, Gabriel, Peine, Sven, Behrens, Georg M.N., Lehmann, Clara, Meurer, Anja, Pauli, Ramona, Postel, Nils, Roider, Julia, Scholten, Stefan, Spinner, Christoph D., Stephan, Christoph, Wolf, Eva, Wyen, Christoph, Richert, Laura, Norman, Paul J., Sauter, Jürgen, Schmidt, Alexander H., Hoelzemer, Angelique, Altfeld, Marcus, Körner, Christian

“…NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells…”
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The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells by Ziegler, Annerose E., Fittje, Pia, Müller, Luisa M., Ahrenstorf, Annika E., Hagemann, Kerri, Hagen, Sven H., Hess, Leonard U., Niehrs, Annika, Poch, Tobias, Ravichandran, Gevitha, Löbl, Sebastian M., Padoan, Benedetta, Brias, Sébastien, Hennesen, Jana, Richard, Myrtille, Richert, Laura, Peine, Sven, Oldhafer, Karl J., Fischer, Lutz, Schramm, Christoph, Martrus, Glòria, Bunders, Madeleine J., Altfeld, Marcus, Lunemann, Sebastian

“…The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell…”
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CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans by Martrus, Glòria, Goebels, Hanna, Langeneckert, Annika E, Kah, Janine, Flomm, Felix, Ziegler, Annerose E, Niehrs, Annika, Löbl, Sebastian M, Russu, Kristina, Hess, Leonard U, Salzberger, Wilhelm, Poch, Tobias, Nashan, Björn, Schramm, Christoph, Oldhafer, Karl J, Dandri, Maura, Koch, Martina, Lunemann, Sebastian, Altfeld, Marcus

“…Macrophages play central roles in inflammatory reactions and initiation of immune responses during infections. More than 80% of total tissue macrophages are…”
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Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver by Peiseler, Moritz, Araujo David, Bruna, Zindel, Joel, Surewaard, Bas G J, Lee, Woo-Yong, Heymann, Felix, Nusse, Ysbrand, Castanheira, Fernanda V S, Shim, Raymond, Guillot, Adrien, Bruneau, Alix, Atif, Jawairia, Perciani, Catia, Ohland, Christina, Ganguli Mukherjee, Priyanka, Niehrs, Annika, Thuenauer, Roland, Altfeld, Marcus, Amrein, Mathias, Liu, Zhaoyuan, Gordon, Paul M K, McCoy, Kathy, Deniset, Justin, MacParland, Sonya, Ginhoux, Florent, Tacke, Frank, Kubes, Paul

“…Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal cells to maintain their identity and serve as the body's central…”
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Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells by Höfle, Johannes, Trenkner, Timo, Kleist, Nadja, Schwane, Vera, Vollmers, Sarah, Barcelona, Bryan, Niehrs, Annika, Fittje, Pia, Huynh‐Tran, Van Hung, Sauter, Jürgen, Schmidt, Alexander H, Peine, Sven, Hoelzemer, Angelique, Richert, Laura, Altfeld, Marcus, Körner, Christian

“…NK cells utilize a large array of receptors to screen their surroundings for aberrant or virus‐infected cells. Given the vast diversity of receptors expressed…”
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HLA-DP on Epithelial Cells enables Tissue Damage by NKp44+ NK Cells in Ulcerative Colitis by Baumdick, Martin E., Niehrs, Annika, Degenhardt, Frauke, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H. M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen, Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Franke, Andre, Altfeld, Marcus, Bunders, Madeleine J.

“…We demonstrate that specific subsets of HLA-DP molecules associated with UC and expressed on intestinal epithelial cells under inflammatory conditions can…”
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Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression by van Stigt Thans, Thomas, Akko, Janet I, Niehrs, Annika, Garcia-Beltran, Wilfredo F, Richert, Laura, Stürzel, Christina M, Ford, Christopher T, Li, Hui, Ochsenbauer, Christina, Kappes, John C, Hahn, Beatrice H, Kirchhoff, Frank, Martrus, Glòria, Sauter, Daniel, Altfeld, Marcus, Hölzemer, Angelique

“…Human immunodeficiency virus type 1 (HIV-1) has evolved elaborate ways to evade immune cell recognition, including downregulation of classical HLA class I…”
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NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells by Padoan, Benedetta, Casar, Christian, Krause, Jenny, Schultheiss, Christoph, Baumdick, Martin E., Niehrs, Annika, Zecher, Britta F., Pujantell, Maria, Yuki, Yuko, Martin, Maureen, Remmerswaal, Ester B.M., Dekker, Tamara, van der Bom-Baylon, Nelly D., Noble, Janelle A., Carrington, Mary, Bemelman, Frederike J., van Lier, Rene A.W., Binder, Mascha, Gagliani, Nicola, Bunders, Madeleine J., Altfeld, Marcus

“…Although natural killer (NK) cells are recognized for their modulation of immune responses, the mechanisms by which human NK cells mediate immune regulation…”
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The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56 bright NK cells by Ziegler, Annerose E, Fittje, Pia, Müller, Luisa M, Ahrenstorf, Annika E, Hagemann, Kerri, Hagen, Sven H, Hess, Leonard U, Niehrs, Annika, Poch, Tobias, Ravichandran, Gevitha, Löbl, Sebastian M, Padoan, Benedetta, Brias, Sébastien, Hennesen, Jana, Richard, Myrtille, Richert, Laura, Peine, Sven, Oldhafer, Karl J, Fischer, Lutz, Schramm, Christoph, Martrus, Glòria, Bunders, Madeleine J, Altfeld, Marcus, Lunemann, Sebastian

“…The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell…”
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KIR3DS1 directs NK cell-mediated protection against human adenovirus infections by Jung, Johannes M, Ching, Wilhelm, Baumdick, Martin E, Hofmann-Sieber, Helga, Bosse, Jens B, Koyro, Tobias, Möller, Kimberly J, Wegner, Lucy, Niehrs, Annika, Russu, Kristina, Ohms, Mareike, Zhang, Wenli, Ehrhardt, Anja, Duisters, Kevin, Spierings, Eric, Hölzemer, Angelique, Körner, Christian, Jansen, Suze A, Peine, Sven, Königs, Ingo, Lütgehetmann, Marc, Perez, Daniel, Reinshagen, Konrad, Lindemans, Caroline A, Altfeld, Marcus, Belderbos, Mirjam, Dobner, Thomas, Bunders, Madeleine J

“…Human adenoviruses (HAdVs) are a major cause for disease in children, in particular after allogeneic hematopoietic stem cell transplantation (allo-HSCT)…”
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