Search Results - "Niehoff, Marc"
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Measurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys
Published in Journal of pharmacological and toxicological methods (01-11-2014)“…The measurement of cardiovascular endpoints in standard toxicology studies remains a challenge as the routinely used non-invasive methods require physical…”
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Physiology and Endocrinology of the Ovarian Cycle in Macaques
Published in Toxicologic pathology (01-12-2008)“…Macaques provide excellent models for preclinical testing and safety assessment of female reproductive toxicants. Currently, cynomolgus monkeys are the…”
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Effects of social housing of sexually mature male cynomolgus monkeys during general and reproductive toxicity evaluation
Published in Reproductive toxicology (Elmsford, N.Y.) (2010)“…We investigated the effects of social housing on reproductive parameters and body weight in mature cynomolgus monkeys, the predominant nonhuman primate model…”
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Considerations on the neurobehavioral assessment (modified Irwin test) in non-human primates
Published in Journal of pharmacological and toxicological methods (01-09-2018)Get full text
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Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics
Published in Journal of applied toxicology (01-09-2014)“…ABSTRACT JNJ‐37822681 is a potent, specific and fast dissociating dopamine D2 receptor antagonist intended for the treatment of schizophrenia. Its nonclinical…”
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