Search Results - "Niederstaetter, Laura"
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Finger sweat analysis enables short interval metabolic biomonitoring in humans
Published in Nature communications (13-10-2021)“…Metabolic biomonitoring in humans is typically based on the sampling of blood, plasma or urine. Although established in the clinical routine, these sampling…”
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The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans
Published in The journal of clinical endocrinology and metabolism (01-07-2020)“…Abstract Background Accumulating evidence links brown adipose tissue (BAT) to increased cold-induced energy expenditure (CIEE) and regulation of lipid…”
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Red blood cell transfusion-related eicosanoid profiles in intensive care patients-A prospective, observational feasibility study
Published in Frontiers in physiology (16-03-2023)“…Eicosanoids are bioactive lipids present in packed red blood cells (PRBCs), and might play a role in transfusion-related immunomodulation (TRIM). We tested the…”
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Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture
Published in Biomolecules (Basel, Switzerland) (15-01-2021)“…Reproducibility issues regarding in vitro cell culture experiments are related to genetic fluctuations and batch-wise variations of biological materials such…”
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Structural Similarity with Cholesterol Reveals Crucial Insights into Mechanisms Sustaining the Immunomodulatory Activity of the Mycotoxin Alternariol
Published in Cells (Basel, Switzerland) (31-03-2020)“…The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may…”
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Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells
Published in Frontiers in pharmacology (10-07-2019)“…While genetic traits and epigenetic modifications mainly encode cell type-specific effector functions, the eventual outcome is also prone to modulation by…”
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INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage
Published in Biomolecules (Basel, Switzerland) (07-09-2022)“…Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses…”
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Determination of a Tumor-Promoting Microenvironment in Recurrent Medulloblastoma: A Multi-Omics Study of Cerebrospinal Fluid
Published in Cancers (26-05-2020)“…Molecular classification of medulloblastoma (MB) is well-established and reflects the cell origin and biological properties of tumor cells. However, limited…”
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The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts
Published in Molecular & cellular proteomics (01-03-2020)“…Proteome profiling data of eight xenografted cutaneous and cerebellar metastasis of human melanoma cells were combined with eicosanoid and glutathione…”
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10
Lipid droplet‐mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib
Published in International journal of cancer (15-09-2020)“…Ponatinib is a small molecule multi‐tyrosine kinase inhibitor clinically approved for anticancer therapy. Molecular mechanisms by which cancer cells develop…”
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Combined Proteome and Eicosanoid Profiling Approach for Revealing Implications of Human Fibroblasts in Chronic Inflammation
Published in Analytical chemistry (Washington) (07-02-2017)“…During inflammation, proteins and lipids act in a concerted fashion, calling for combined analyses. Fibroblasts are powerful mediators of chronic inflammation…”
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Abstract 1839: Lipid metabolism as target and modulator of KP1339 anticancer activity
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract Acquired therapy resistance of diverse cancer types frequently involves changed metabolic processes linked to altered cellular lipid uptake or de novo…”
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INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of Itrans/I-Arachidonic Acids and Affects Eicosanoid Release during Storage
Published in Biomolecules (Basel, Switzerland) (01-09-2022)“…Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses…”
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14
The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts
Published in Molecular & cellular proteomics (01-03-2020)“…The prediction of metastatic properties from molecular analyses still poses a major challenge. Here we aimed at the classification of metastasis-related cell…”
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