Search Results - "Niederer, S A"

Image-Based Personalization of Cardiac Anatomy for Coupled Electromechanical Modeling by Crozier, A., Augustin, C. M., Neic, A., Prassl, A. J., Holler, M., Fastl, T. E., Hennemuth, A., Bredies, K., Kuehne, T., Bishop, M. J., Niederer, S. A., Plank, G.

“…Computational models of cardiac electromechanics (EM) are increasingly being applied to clinical problems, with patient-specific models being generated from…”
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A meta-analysis of cardiac electrophysiology computational models by Niederer, S. A., Fink, M., Noble, D., Smith, N. P.

“…Computational models of cardiac electrophysiology are exemplar demonstrations of the integration of multiple data sets into a consistent biophysical framework…”
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A Quantitative Analysis of Cardiac Myocyte Relaxation: A Simulation Study by Niederer, S.A., Hunter, P.J., Smith, N.P.

“…The determinants of relaxation in cardiac muscle are poorly understood, yet compromised relaxation accompanies various pathologies and impaired pump function…”
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Interpreting genetic effects through models of cardiac electromechanics by Niederer, S A, Land, S, Omholt, S W, Smith, N P

“…Multiscale models of cardiac electromechanics are being increasingly focused on understanding how genetic variation and environment underpin multiple disease…”
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Mechanism of doxorubicin cardiotoxicity evaluated by integrating multiple molecular effects into a biophysical model by Fernandez‐Chas, M, Curtis, M J, Niederer, S A

“…Background and Purpose Doxorubicin (DOX) is an effective cancer therapeutic agent but causes therapy‐limiting cardiotoxicity. The effects of DOX and its…”
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Calcium Dynamics in the Ventricular Myocytes of SERCA2 Knockout Mice: A Modeling Study by Li, L., Louch, W.E., Niederer, S.A., Andersson, K.B., Christensen, G., Sejersted, O.M., Smith, N.P.

“…We describe a simulation study of Ca 2+ dynamics in mice with cardiomyocyte-specific conditional excision of the sarco(endo)plasmic reticulum calcium ATPase…”
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Creation and application of virtual patient cohorts of heart models by Niederer, S A, Aboelkassem, Y, Cantwell, C D, Corrado, C, Coveney, S, Cherry, E M, Delhaas, T, Fenton, F H, Panfilov, A V, Pathmanathan, P, Plank, G, Riabiz, M, Roney, C H, Dos Santos, R W, Wang, L

“…Patient-specific cardiac models are now being used to guide therapies. The increased use of patient-specific cardiac simulations in clinical care will give…”
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Modelling and measuring electromechanical coupling in the rat heart by Niederer, S. A., Ter Keurs, H. E. D. J., Smith, N. P.

“…Tension-dependent binding of Ca 2+ to troponin C in the cardiac myocyte has been shown to play an important role in the regulation of Ca 2+ and the activation…”
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Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats by Longobardi, S, Lewalle, A, Coveney, S, Sjaastad, I, Espe, E K S, Louch, W E, Musante, C J, Sher, A, Niederer, S A

“…Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical cardiac models offer a systematic approach for studying these…”
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Coupling multi-physics models to cardiac mechanics by Nordsletten, D.A., Niederer, S.A., Nash, M.P., Hunter, P.J., Smith, N.P.

“…We outline and review the mathematical framework for representing mechanical deformation and contraction of the cardiac ventricles, and how this behaviour…”
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Measuring and Modeling Chloride-Hydroxyl Exchange in the Guinea-Pig Ventricular Myocyte by Niederer, S.A., Swietach, P., Wilson, D.A., Smith, N.P., Vaughan-Jones, R.D.

“…Protons are powerful modulators of cardiac function. Their intracellular concentration is regulated by sarcolemmal ion transporters that export or import H…”
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At the heart of computational modelling by Niederer, S. A., Smith, N. P.

“…The link between experimental data and biophysically based mathematical models is key to computational simulation meeting its potential to provide…”
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Is the rapidly paced pig the optimal model for endocardial cardiac resynchronization therapy? by Niederer, S A, Gould, J, Sieniewicz, B, Prinzen, F, Rinaldi, C A

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Efficient Computational Methods for Strongly Coupled Cardiac Electromechanics by Land, Sander, Niederer, Steven A., Smith, Nicolas P.

“…Strongly coupled cardiac electromechanical models can further our understanding of the relative importance of feedback mechanisms in the heart, but…”
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A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform by Li, L, Niederer, S A, Idigo, W, Zhang, Y H, Swietach, P, Casadei, B, Smith, N P

“…Mathematical modeling of Ca(2+) dynamics in the heart has the potential to provide an integrated understanding of Ca(2+)-handling mechanisms. However, many…”
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Left ventricular outflow obstruction predicts increase in systolic pressure gradients and blood residence time after transcatheter mitral valve replacement by De Vecchi, Adelaide, Marlevi, David, Nordsletten, David A., Ntalas, Ioannis, Leipsic, Jonathon, Bapat, Vinayak, Rajani, Ronak, Niederer, Steven A.

“…Left ventricular outflow tract (LVOT) obstruction is a relatively common consequence of transcatheter mitral valve replacement (TMVR). Although LVOT…”
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Computational modelling of cardiac electrophysiology: explanation of the variability of results from different numerical solvers by Pathmanathan, P., Bernabeu, M.O., Niederer, S.A., Gavaghan, D.J., Kay, D.

“…SUMMARY A recent verification study compared 11 large‐scale cardiac electrophysiology solvers on an unambiguously defined common problem. An unexpected amount…”
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Energetic consequences of mechanical loads by Loiselle, D.S., Crampin, E.J., Niederer, S.A., Smith, N.P., Barclay, C.J.

“…In this brief review, we have focussed largely on the well-established, but essentially phenomenological, linear relationship between the energy expenditure of…”
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Impact of iNAV and dNAV 3D LGE-CMR on the assessment of atrial fibrosis in atrial fibrillation patients by Hopman, L H G, Solis-Lemus, J A, Hofman, M B M, Bhagirath, P, Borodzicz-Jazdzyk, S, Van Pouderoijen, N, Krafft, A J, Schmidt, M, Allaart, C P, Niederer, S A, Gotte, M J W

“…Abstract Background Late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) imaging serves as a valuable non-invasive tool for visualizing and…”
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Optimising electrical performance of leadless cardiac resynchronisation therapy and leadless LV septal pacing by Wijesuriya, N, Strocchi, M, Mehta, V S, Elliott, M K, De Vere, F, Howell, S, Sidhu, B, Mannakkara, N, Little, I, Martic, D, Carlisle, L, Kwan, J, Bosco, P, Niederer, S A, Rinaldi, C A

“…Abstract Introduction Leadless left ventricular (LV) endocardial pacing with the WiSE-CRT System is an emerging form of cardiac resynchronisation therapy…”
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