Search Results - "Niedbala, Michael J."

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration by Kettle, Jason G, Bagal, Sharan K, Barratt, Derek, Bodnarchuk, Michael S, Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J, Cosulich, Sabina, Davies, Michael, Davies, Nichola L, Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Cortés González, Miguel A, Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D, Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J, Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R, Ross, Sarah, Sanders, Matthew G, Schou, Magnus, Simpson, Iain, Steward, Oliver

“…The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable…”
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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C by Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Niedbala, Michael J, Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M, Ross, Sarah, Sanders, Matthew G, Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman

“…KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now…”
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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C by Kettle, Jason G., Bagal, Sharan K., Bickerton, Sue, Bodnarchuk, Michael S., Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J., Cassar, Doyle J., Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L., Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J., Liu, Libin, Niedbala, Michael J., Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M., Ross, Sarah, Sanders, Matthew G., Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman

“…KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now…”
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Localization and activation of type IV collagenase/gelatinase at endothelial focal contacts by Partridge, C A, Phillips, P G, Niedbala, M J, Jeffrey, J J

“…The cell-surface localization and site of activation of type IV collagenases/gelatinases (matrix metalloproteinases, MMP) in bovine pulmonary microvascular…”
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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration by Kettle, Jason G., Bagal, Sharan K., Barratt, Derek, Bodnarchuk, Michael S., Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J., Cosulich, Sabina, Davies, Michael, Davies, Nichola L., Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J., Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Cortés González, Miguel A., Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D., Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M., Lamont, Scott, Lewis, Hilary J., Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J., Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R., Ross, Sarah, Sanders, Matthew G., Schou, Magnus, Simpson, Iain, Steward, Oliver

“…The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable…”
Get full text

Regulation by epidermal growth factor of human squamous cell carcinoma plasminogen activator-mediated proteolysis of extracellular matrix by NIEDBALA, M. J, SARTORELLI, A. C

“…The interaction of epidermal growth factor (EGF) with specific cell surface receptors initiates biochemical events in target cells which result in cellular…”
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Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis by Ahrens, D, Koch, A E, Pope, R M, Stein-Picarella, M, Niedbala, M J

“…To determine the expression of matrix metalloproteinase 9/gelatinase B (MMP-9) in synovial fluid (SF), plasma, and synovial tissue from individuals with…”
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Role of glycosidases in human ovarian carcinoma cell mediated degradation of subendothelial extracellular matrix by NIEDBALA, M. J, MADIYALAKAN, R, MATTA, K, CRICKARD, K, SHARMA, M, BERNACKI, R. J

“…Penetration of the extracellular matrix (ECM) by tumor cells, an event which occurs at various stages of the metastatic process, involves tumor cell…”
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Tumor Necrosis Factor Induction of Endothelial Cell Urokinase-Type Plasminogen Activator Mediated Proteolysis of Extracellular Matrix and Its Antagonism by γ-Interferon by Niedbala, Michael J., Picarella, Monica Stein

“…Tumor necrosis factor (TNF) has a profound capacity to alter the endothelial cell phenotype that includes morphologic and functional changes that may be…”
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Role of Protein Kinase C in Tumor Necrosis Factor Induction of Endothelial Cell Urokinase-Type Plasminogen Activator by Niedbala, Michael J., Stein-Picarella, Monica

“…Tumor necrosis factor (TNF) can promote endothelial cell transcription, synthesis, and secretion of urokinase plasminogen activator (uPA) augmenting…”
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Isolation, cultivation, and partial characterization of microvascular endothelium derived from human lung by Carley, W W, Niedbala, M J, Gerritsen, M E

“…Primary cultures of peripheral lung lobes were grown in a highly supplemented medium. Human lung endothelial cells (HLE) were isolated from the mixed…”
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Glycosidases in cancer and invasion by Bernacki, R J, Niedbala, M J, Korytnyk, W

“…Glycosidases have been demonstrated to be elevated in the interstitial fluid of tumors, sera of animals and patients with tumors, and in some tumor tissue as…”
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Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix. An in vitro model system for studying tumor cell adhesion and invasion by Niedbala, M J, Crickard, K, Bernacki, R J

“…Human ovarian tumors metastasize by direct extension into the peritoneal cavity leading to tumor cell implantation onto peritoneal surfaces. Successful…”
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Localization and characterization of matrix metalloproteinase-9 in experimental rat adjuvant arthritis by Stein-Picarella, M, Ahrens, D, Mase, C, Golden, H, Niedbala, M J

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In vitro degradation of extracellular matrix by human ovarian carcinoma cells by Niedbala, M J, Crickard, K, Bernacki, R J

“…Better in vitro models are needed to elucidate the mechanisms underlying tissue destruction by human tumor cells. To address this matter recently isolated and…”
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Tumor necrosis factor regulation of endothelial cell extracellular proteolysis: the role of urokinase plasminogen activator by Niedbala, M J, Stein-Picarella, M

“…Morphological and functional changes in the endothelial cell phenotype which may be central to proinflammatory processes can be elicited by tumor necrosis…”
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