Search Results - "Nicot, Simon"

Prion-like acceleration of a synucleinopathy in a transgenic mouse model by Mougenot, Anne-Laure, Nicot, Simon, Bencsik, Anna, Morignat, Eric, Verchère, Jérémy, Lakhdar, Latefa, Legastelois, Stéphane, Baron, Thierry

“…Abstract Our aim in this study was to investigate experimentally the possible in vivo transmission of a synucleinopathy, using a transgenic mouse model (TgM83)…”
Get full text

The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation by Mugat, Bruno, Nicot, Simon, Varela-Chavez, Carolina, Jourdan, Christophe, Sato, Kaoru, Basyuk, Eugenia, Juge, François, Siomi, Mikiko C., Pélisson, Alain, Chambeyron, Séverine

“…In eukaryotes, trimethylation of lysine 9 on histone H3 (H3K9) is associated with transcriptional silencing of transposable elements (TEs). In drosophila…”
Get full text

Rapid and Highly Sensitive Detection of Variant Creutzfeldt-Jakob Disease Abnormal Prion Protein on Steel Surfaces by Protein Misfolding Cyclic Amplification: Application to Prion Decontamination Studies by Belondrade, Maxime, Nicot, Simon, Béringue, Vincent, Coste, Joliette, Lehmann, Sylvain, Bougard, Daisy

“…The prevalence of variant Creutzfeldt-Jakob disease (vCJD) in the population remains uncertain, although it has been estimated that 1 in 2000 people in the…”
Get full text

Strain-Specific Barriers against Bovine Prions in Hamsters by NICOT, Simon, BARON, Thierry

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Sensitive protein misfolding cyclic amplification of sporadic Creutzfeldt–Jakob disease prions is strongly seed and substrate dependent by Bélondrade, Maxime, Nicot, Simon, Mayran, Charly, Bruyere-Ostells, Lilian, Almela, Florian, Di Bari, Michele A., Levavasseur, Etienne, Watts, Joel C., Fournier-Wirth, Chantal, Lehmann, Sylvain, Haïk, Stéphane, Nonno, Romolo, Bougard, Daisy

“…Unlike variant Creutzfeldt–Jakob disease prions, sporadic Creutzfeldt–Jakob disease prions have been shown to be difficult to amplify in vitro by protein…”
Get full text

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation by Alleaume-Butaux, Aurélie, Nicot, Simon, Pietri, Mathéa, Baudry, Anne, Dakowski, Caroline, Tixador, Philippe, Ardila-Osorio, Hector, Haeberlé, Anne-Marie, Bailly, Yannick, Peyrin, Jean-Michel, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit

“…In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects,…”
Get full text

Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein by Bétemps, Dominique, Arsac, Jean-Noël, Nicot, Simon, Canal, Dominique, Tlili, Habiba, Belondrade, Maxime, Morignat, Eric, Verchère, Jérémy, Gaillard, Damien, Bruyère-Ostells, Lilian, Mayran, Charly, Lakhdar, Latifa, Bougard, Daisy, Baron, Thierry

“…Human neurodegenerative diseases associated with the misfolding of the alpha-synuclein (aS) protein (synucleinopathies) are similar to prion diseases to the…”
Get full text

L-Type Bovine Spongiform Encephalopathy in Genetically Susceptible and Resistant Sheep: Changes in Prion Strain or Phenotypic Plasticity of the Disease-Associated Prion Protein? by Nicot, Simon, Bencsik, Anna, Migliore, Sergio, Canal, Dominique, Leboidre, Mikael, Agrimi, Umberto, Nonno, Romolo, Baron, Thierry

“…Background. Sheep with prion protein (PrP) gene polymorphisms QQ171 and RQ171 were shown to be susceptible to the prion causing L-type bovine spongiform…”
Get full text

Oral transmission of L-type bovine spongiform encephalopathy in primate model by Mestre-Francés, Nadine, Nicot, Simon, Rouland, Sylvie, Biacabe, Anne-Gaëlle, Quadrio, Isabelle, Perret-Liaudet, Armand, Baron, Thierry, Verdier, Jean-Michel

“…We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain…”
Get full text

Correlation between Bioassay and Protein Misfolding Cyclic Amplification for Variant Creutzfeldt-Jakob Disease Decontamination Studies by Bélondrade, Maxime, Jas-Duval, Christelle, Nicot, Simon, Bruyère-Ostells, Lilian, Mayran, Charly, Herzog, Laetitia, Reine, Fabienne, Torres, Juan Maria, Fournier-Wirth, Chantal, Béringue, Vincent, Lehmann, Sylvain, Bougard, Daisy

“…To date, approximately 500 iatrogenic Creutzfeldt-Jakob disease cases have been reported worldwide, most of them resulting from cadaveric dura mater graft and…”
Get full text

Differentiation of prions from L-type BSE versus sporadic Creutzfeldt-Jakob disease by Nicot, Simon, Bencsik, Anna, Morignat, Eric, Mestre-Francés, Nadine, Perret-Liaudet, Armand, Baron, Thierry

“…We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the…”
Get full text

Detection of prions in the plasma of presymptomatic and symptomatic patients with variant Creutzfeldt-Jakob disease by Bougard, Daisy, Brandel, Jean-Philippe, Bélondrade, Maxime, Béringue, Vincent, Segarra, Christiane, Fleury, Hervé, Laplanche, Jean-Louis, Mayran, Charly, Nicot, Simon, Green, Alison, Welaratne, Arlette, Narbey, David, Fournier-Wirth, Chantal, Knight, Richard, Will, Robert, Tiberghien, Pierre, Haïk, Stéphane, Coste, Joliette

“…Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease resulting from the consumption of meat products contaminated by the agent causing bovine…”
Get more information

Seeded propagation of α‐synuclein aggregation in mouse brain using protein misfolding cyclic amplification by Nicot, Simon, Verchère, Jérémy, Bélondrade, Maxime, Mayran, Charly, Bétemps, Dominique, Bougard, Daisy, Baron, Thierry

“…α‐Synuclein (α‐syn) protein aggregation is associated with several neurodegenerative disorders collectively referred to as synucleinopathies, including…”
Get full text

A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation by Nicot, Simon, Gillard, Ghislain, Impheng, Hathaichanok, Joachimiak, Ewa, Urbach, Serge, Mochizuki, Kazufumi, Wloga, Dorota, Juge, François, Rogowski, Krzysztof

“…Tubulin posttranslational modifications represent an important mechanism involved in the regulation of microtubule functions. The most widespread among them…”
Get full text

Transmission of Prion Strains in a Transgenic Mouse Model Overexpressing Human A53T Mutated α-Synuclein by Mougenot, Anne-Laure J, Bencsik, Anna, Nicot, Simon, Vulin, Johann, Morignat, Eric, Verchère, Jérémy, Bétemps, Dominique, Lakhdar, Latefa, Legastelois, Stéphane, Baron, Thierry G

“…There is a growing interest in the potential roles of misfolded protein interactions in neurodegeneration. To investigate this issue, we inoculated 3 prion…”
Get full text

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation: e1005073 by Alleaume-Butaux, Aurélie, Nicot, Simon, Pietri, Mathéa, Baudry, Anne, Dakowski, Caroline, Tixador, Philippe, Ardila-Osorio, Hector, Haeberlé, Anne-Marie, Bailly, Yannick, Peyrin, Jean-Michel, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit

“…In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects,…”
Get full text

Rapid and Highly Sensitive Detection of Variant Creutzfeldt - Jakob Disease Abnormal Prion Protein on Steel Surfaces by Protein Misfolding Cyclic Amplification: Application to Prion Decontamination Studies: e0146833 by Belondrade, Maxime, Nicot, Simon, Beringue, Vincent, Coste, Joliette, Lehmann, Sylvain, Bougard, Daisy

“…The prevalence of variant Creutzfeldt-Jakob disease (vCJD) in the population remains uncertain, although it has been estimated that 1 in 2000 people in the…”
Get full text

Transmission of Prion Strains in a Transgenic Mouse Model Overexpressing Human A53T Mutated [alpha]-Synuclein by Mougenot, Anne-Laure J, Bencsik, Anna, Nicot, Simon, Vulin, Johann, Morignat, Eric, Verchère, Jérémy, Bétemps, Dominique, Lakhdar, Latefa, Legastelois, Stéphane, Baron, Thierry G

“…There is a growing interest in the potential roles of misfolded protein interactions in neurodegeneration. To investigate this issue, we inoculated 3 prion…”
Get full text

Strain-specific proteolytic processing of the prion protein in prion diseases of ruminants transmitted in ovine transgenic mice by Nicot, Simon, Baron, Thierry G.M

“…The cerebral prion protein (PrP) isolated in the absence of proteinase K digestion, from ruminants prion sources transmitted to ovine transgenic mice, was…”
Get full text

Prévention du risque prion en transfusion : mise en place d’un modèle expérimental d’étude de l’infectiosité du sang by Mayran, Charly, Perrier, Véronique, Bélondrade, Maxime, Imberdis, Thibault, Nicot, Simon, Lafon, Pierre-André, Huetter, Elisabeth, Bruyãre-Ostells, Lilian, Martinez, Maria-Teresa Alvarez, Arnaud, Jacques-Damien, Coste, Joliette, Bougard, Daisy

“…Le risque de transmission de la variante de la maladie de Creutzfeldt-Jakob (vMCJ) par les produits sanguins est avéré. Quatre cas de vMCJ, liés à la…”
Get full text