Search Results - "Nicosia, Simonetta"

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors by Brink, Charles, Dahlén, Sven-Erik, Drazen, Jeffrey, Evans, Jilly F, Hay, Douglas W P, Nicosia, Simonetta, Serhan, Charles N, Shimizu, Takao, Yokomizo, Takehiko

“…The leukotrienes and lipoxins are biologically active metabolites derived from arachidonic acid. Their diverse and potent actions are associated with specific…”
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Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway by Ciccarelli, Renata, D'Alimonte, Iolanda, Santavenere, Clara, D'Auro, Mariagrazia, Ballerini, Patrizia, Nargi, Eleonora, Buccella, Silvana, Nicosia Folco, Simonetta, Giancarlo, Caciagli, Francesco, Di Iorio, Patrizia

“…Cysteinyl‐leukotrienes (cys‐LTs), potent mediators in inflammatory diseases, are produced by nervous tissue, but their cellular source and role in the brain…”
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Characterization of the Ca2+ responses evoked by ATP and other nucleotides in mammalian brain astrocytes by Centemeri, Carlo, Bolego, Chiara, Abbracchio, Maria P., Cattabeni, Flaminio, Puglisi, Lina, Burnstock, Geoffrey, Nicosia, Simonetta

“…1 This study was aimed at characterizing ATP‐induced rises in cytosolic free calcium ion, [Ca2+]i, in a population of rat striatal astrocytes loaded with the…”
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Role of sodium in intracellular calcium elevation and leukotriene B4 formation by receptor-mediated activation of human neutrophils by TEDESCHI, Alberto, CICERI, Paola, ZARINI, Simona, LORINI, Maurizio, DI DONATO, Manuela, NICOSIA, Simonetta, MIADONNA, Antonio, SALA, Angelo

“…The role of Na(+) and Na(+) exchangers in intracellular Ca(2+) elevation and leukotriene B(4) (LTBs) formation was investigated in granulocyte macrophage…”
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Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma by Capra, V, Nicosia, S, Ragnini, D, Mezzetti, M, Keppler, D, Rovati, G E

“…We report the characterization of two distinct binding sites with receptor characteristics for leukotriene (LT)D4 and LTC4 in membranes from human lung…”
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myc-immortalized microglial cells express a functional platelet-activating factor receptor by Righi, M, Letari, O, Sacerdote, P, Marangoni, F, Miozzo, A, Nicosia, S

“…The autacoid platelet-activating factor (PAF) takes part in a complex network of interactions regarding the cellular components of nervous tissues. Efforts…”
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Pharmacological characterization of the cysteinyl‐leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro by Capra, Valérie, Bolla, Manlio, Angelo Belloni, Pier, Mezzetti, Maurizio, Carlo Folco, G., Nicosia, Simonetta, Enrico Rovati, G.

“…Cysteinyl‐leukotrienes (cysteinyl‐LTs) are important mediators in the pathogenesis of asthma. They cause bronchoconstriction, mucus hypersecretion, increase in…”
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Production of leukotrienes in a model of focal cerebral ischaemia in the rat by Ciceri, Paola, Rabuffetti, Monica, Monopoli, Angela, Nicosia, Simonetta

“…The aim of this work was to evaluate the role of leukotrienes in brain damage in vivo in a model of focal cerebral ischaemia in the rat, obtained by permanent…”
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Characterization of the Ca 2+ responses evoked by ATP and other nucleotides in mammalian brain astrocytes by Centemeri, Carlo, Bolego, Chiara, Abbracchio, Maria P., Cattabeni, Flaminio, Puglisi, Lina, Burnstock, Geoffrey, Nicosia, Simonetta

“…This study was aimed at characterizing ATP‐induced rises in cytosolic free calcium ion, [Ca 2+ ] i , in a population of rat striatal astrocytes loaded with the…”
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Pharmacological differences among CysLT1 receptor antagonists with respect to LTC4 and LTD4 in human lung parenchyma by RAVASI, Saula, CAPRA, Valérie, PANIGALLI, Tiziana, ROVATI, G. Enrico, NICOSIA, Simonetta

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Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation by Capra, Valérie, Habib, Aı̈da, Accomazzo, Maria Rosa, Ravasi, Saula, Citro, Simona, Levy-Toledano, Sylviane, Nicosia, Simonetta, Rovati, G.Enrico

“…Thromboxane A 2 has been implicated as a mediator of bronchial hyperresponsiveness in asthma. Modulating agents are currently marketed in Japan and under…”
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Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells by Capra, Valérie, Accomazzo, Maria Rosa, Ravasi, Saula, Parenti, Marco, Macchia, Marco, Nicosia, Simonetta, Rovati, G Enrico

“…We investigated signal transduction pathways for LTD4 in the human promonocytic cell line U937 known, upon differentiation, to express CysLT1 receptors. We…”
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Bell-shaped curves for prostaglandin-induced modulation of adenylate cyclase: two mutually opposing effects by Accomazzo, Maria Rosa, Cattaneo, Sarah, Nicosia, Simonetta, Rovati, G.Enrico

“…Each of the natural prostanoid is at least one order of magnitude more potent for its specific receptor (DP, EP, FP, IP and TP) than any of the other…”
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Pharmacological differences among CysLT 1 receptor antagonists with respect to LTC 4 and LTD 4 in human lung parenchyma by Ravasi, Saula, Capra, Valérie, Panigalli, Tiziana, Rovati, G.Enrico, Nicosia, Simonetta

“…We have previously reported, by means of equilibrium binding studies, the existence of two distinct binding sites with receptor characteristics for LTC 4 and…”
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Lower efficacy: interaction with an inhibitory receptor or partial agonism? by Rovati, G E, Nicosia, S

“…It is very common in practice to find that some concentration-response curves are 'bell shaped', and this phenomenon also applies to partial agonist curves. On…”
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Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma by Ravasi, Saula, Capra, Valérie, Panigalli, Tiziana, Rovati, G Enrico, Nicosia, Simonetta

“…We have previously reported, by means of equilibrium binding studies, the existence of two distinct binding sites with receptor characteristics for LTC(4) and…”
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Evaluation of the effects of anti-thromboxane agents in platelet–vessel wall interaction by Buccellati, Carola, Ciceri, Paola, Ballerio, Rossana, Casagrande, Cesare, Folco, Giancarlo, Nicosia, Simonetta

“…We evaluated the capacity of anti-aggregating agents to influence thromboxane A 2 and prostacyclin formation, arachidonic acid-endoperoxide redirection,…”
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Role of sodium in intracellular calcium elevation and leukotriene B 4 formation by receptor-mediated activation of human neutrophils by Tedeschi, Alberto, Ciceri, Paola, Zarini, Simona, Lorini, Maurizio, Di Donato, Manuela, Nicosia, Simonetta, Miadonna, Antonio, Sala, Angelo

“…The role of Na + and Na + exchangers in intracellular Ca 2+ elevation and leukotriene B 4 (LTBs) formation was investigated in granulocyte macrophage…”
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Internalization and down-regulation of the prostacyclin receptor in human platelets by Giovanazzi, S, Accomazzo, M R, Letari, O, Oliva, D, Nicosia, S

“…The internalization of [3H]iloprost, a prostacyclin analogue, was studied in human platelets by binding studies. After incubation with [3H]iloprost at 37…”
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Involvement of prenylated proteins in calcium signaling induced by LTD 4 in differentiated U937 cells by Capra, Valérie, Accomazzo, Maria Rosa, Ravasi, Saula, Parenti, Marco, Macchia, Marco, Nicosia, Simonetta, Rovati, G.Enrico

“…We investigated signal transduction pathways for LTD 4 in the human promonocytic cell line U937 known, upon differentiation, to express CysLT 1 receptors. We…”
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