Search Results - "Nicoll, R. A"

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization by ZOTOVA, Elina, BHARAMBE, Viraj, CHEAVEAU, Matthew, MORGAN, William, HOLMES, Clive, HARRIS, Scott, NEAL, James W, LOVE, Seth, NICOLL, James A. R, BOCHE, Delphine

“…Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-β immunotherapy. We investigated the expression of…”
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The mitochondrial protein TSPO in Alzheimer's disease: relation to the severity of AD pathology and the neuroinflammatory environment by Garland, Emma F, Dennett, Oliver, Lau, Laurie C, Chatelet, David S, Bottlaender, Michel, Nicoll, James A R, Boche, Delphine

“…The 18kD translocator protein (TSPO) is used as a positron emission tomography (PET) target to quantify neuroinflammation in patients. In Alzheimer's disease…”
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Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy by Weller, Roy O., Boche, Delphine, Nicoll, James A. R.

“…The introduction of immunotherapy and its ultimate success will require re-evaluation of the pathogenesis of Alzheimer’s disease particularly with regard to…”
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Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer's disease by Moro, Maria Luisa, Phillips, Andrew Stephen, Gaimster, Katie, Paul, Christian, Mudher, Amritpal, Nicoll, James A R, Boche, Delphine

“…Alzheimer's disease (AD) is the most common cause of dementia among older adults. Accumulation of amyloid-β (Aβ) in the brain is considered central in AD…”
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Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development by Elias, G.M, Elias, L.A.B, Apostolides, P.F, Kriegstein, A.R, Nicoll, R.A

“…The development of glutamatergic synapses involves changes in the number and type of receptors present at the postsynaptic density. To elucidate molecular…”
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PKR modulates abnormal brain signaling in experimental obesity by Taga, Mariko, Mouton-Liger, François, Sadoune, Malha, Gourmaud, Sarah, Norman, Jenny, Tible, Marion, Thomasseau, Sylvie, Paquet, Claire, Nicoll, James A R, Boche, Delphine, Hugon, Jacques

“…Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic inflammation and are obvious risk factors for Alzheimer's…”
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Systemic infection modifies the neuroinflammatory response in late stage Alzheimer's disease by Rakic, Sonja, Hung, Yat M A, Smith, Matthew, So, Denise, Tayler, Hannah M, Varney, William, Wild, Joe, Harris, Scott, Holmes, Clive, Love, Seth, Stewart, William, Nicoll, James A R, Boche, Delphine

“…Clinical studies indicate that systemic infections accelerate cognitive decline in Alzheimer's disease. Animal models suggest that this may be due to enhanced…”
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Microglial alterations in human Alzheimer's disease following Aβ42 immunization by Zotova, E., Holmes, C., Johnston, D., Neal, J. W., Nicoll, J. A. R., Boche, D.

“…E. Zotova, C. Holmes, D. Johnston, J. W. Neal, J. A. R. Nicoll and D. Boche (2011) Neuropathology and Applied Neurobiology37, 513–524 Microglial alterations in…”
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Review: Activation patterns of microglia and their identification in the human brain by Boche, D., Perry, V. H., Nicoll, J. A. R.

“…Microglia in the central nervous system are usually maintained in a quiescent state. When activated, they can perform many diverse functions which may be…”
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Localized microglia dysregulation impairs central nervous system myelination in development by Holloway, Rebecca K, Zhang, Liang, Molina-Gonzalez, Irene, Ton, Kathy, Nicoll, James A R, Boardman, James P, Liang, Yan, Williams, Anna, Miron, Veronique E

“…Myelination of neuronal axons is a critical aspect of central nervous system development and function. However, the fundamental cellular and molecular…”
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Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy by Franco-Bocanegra, Diana K., Gourari, Yamina, McAuley, Ciaran, Chatelet, David S., Johnston, David A., Nicoll, James A. R., Boche, Delphine

“…Microglia are the brain immune cells and their function is highly dependent on cell motility. It was hypothesised that morphological variability leads to…”
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Microglia in neurodegenerative disease by Holmes, Clive, Perry, V. Hugh, Nicoll, James A. R

“…Microglia rapidly adopt an activated phenotype in response to brain injury and disease, which suggests that they could act as diagnostic markers of…”
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Expression Mechanisms Underlying NMDA Receptor-Dependent Long-Term Potentiation by NICOLL, R. A., MALENKA, R. C.

“…Long‐term potentiation (LTP) is currently the best available cellular model for learning and memory in the mammalian brain. In the CA1 region of the…”
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Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses by Nicoll, Roger A, Wilson, Rachel I

“…Marijuana affects brain function primarily by activating the G-protein-coupled cannabinoid receptor-1 (CB1), which is expressed throughout the brain at high…”
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Investigating interventions in Alzheimer's disease with computer simulation models by Proctor, Carole J, Boche, Delphine, Gray, Douglas A, Nicoll, James A R

“…Progress in the development of therapeutic interventions to treat or slow the progression of Alzheimer's disease has been hampered by lack of efficacy and…”
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Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer's Disease by Franco-Bocanegra, Diana K, McAuley, Ciaran, Nicoll, James A R, Boche, Delphine

“…Microglia are the tissue-resident immune cells of the central nervous system, where they constitute the first line of defense against any pathogens or injury…”
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EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations by Eggens, Veerle Rc, Barth, Peter G, Niermeijer, Jikke-Mien F, Berg, Jonathan N, Darin, Niklas, Dixit, Abhijit, Fluss, Joel, Foulds, Nicola, Fowler, Darren, Hortobágyi, Tibor, Jacques, Thomas, King, Mary D, Makrythanasis, Periklis, Máté, Adrienn, Nicoll, James A R, O'Rourke, Declan, Price, Sue, Williams, Andrew N, Wilson, Louise, Suri, Mohnish, Sztriha, Laszlo, Dijns-de Wissel, Marit B, van Meegen, Mia T, van Ruissen, Fred, Aronica, Eleonora, Troost, Dirk, Majoie, Charles Blm, Marquering, Henk A, Poll-Thé, Bwee Tien, Baas, Frank

“…Pontocerebellar hypoplasia (PCH) represents a group of neurodegenerative disorders with prenatal onset. Eight subtypes have been described thus far (PCH1-8)…”
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TREM2 expression in the human brain: a marker of monocyte recruitment? by Fahrenhold, Marie, Rakic, Sonja, Classey, John, Brayne, Carol, Ince, Paul G., Nicoll, James A. R., Boche, Delphine

“…Mutation in the triggering receptor expressed on myeloid cells (TREM) 2 gene has been identified as a risk factor for several neurodegenerative diseases…”
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Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele by Hawkes, Cheryl A, Sullivan, Patrick M, Hands, Sarah, Weller, Roy O, Nicoll, James A R, Carare, Roxana O

“…Failure of elimination of amyloid-β (Aβ) from the brain and vasculature appears to be a key factor in the etiology of sporadic Alzheimer's disease (AD) and…”
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Microglial immunophenotype in dementia with Alzheimer's pathology by Minett, Thais, Classey, John, Matthews, Fiona E, Fahrenhold, Marie, Taga, Mariko, Brayne, Carol, Ince, Paul G, Nicoll, James A R, Boche, Delphine

“…Genetic risk factors for Alzheimer's disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that…”
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