Search Results - "Nicolas, H"

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks by Schmitges, Frank W., Prusty, Archana B., Faty, Mahamadou, Stützer, Alexandra, Lingaraju, Gondichatnahalli M., Aiwazian, Jonathan, Sack, Ragna, Hess, Daniel, Li, Ling, Zhou, Shaolian, Bunker, Richard D., Wirth, Urs, Bouwmeester, Tewis, Bauer, Andreas, Ly-Hartig, Nga, Zhao, Kehao, Chan, Homan, Gu, Justin, Gut, Heinz, Fischle, Wolfgang, Müller, Jürg, Thomä, Nicolas H.

“…The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2…”
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Determinants and dynamics of genome accessibility by Bell, Oliver, Schübeler, Dirk, Tiwari, Vijay K, Thomä, Nicolas H

“…Key Points Chromatin packaging of genomic DNA restricts accessibility for regulatory proteins but also provides an opportunity to regulate genomic function by…”
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Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN by Sievers, Quinlan L, Petzold, Georg, Bunker, Richard D, Renneville, Aline, Słabicki, Mikołaj, Liddicoat, Brian J, Abdulrahman, Wassim, Mikkelsen, Tarjei, Ebert, Benjamin L, Thomä, Nicolas H

“…The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros…”
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Structural mechanism of cGAS inhibition by the nucleosome by Pathare, Ganesh R., Decout, Alexiane, Glück, Selene, Cavadini, Simone, Makasheva, Kristina, Hovius, Ruud, Kempf, Georg, Weiss, Joscha, Kozicka, Zuzanna, Guey, Baptiste, Melenec, Pauline, Fierz, Beat, Thomä, Nicolas H., Ablasser, Andrea

“…The DNA sensor cyclic GMP–AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer 1 . Upon activation…”
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Reading the chromatinized genome by Michael, Alicia K., Thomä, Nicolas H.

“…Eukaryotic DNA-binding proteins operate in the context of chromatin, where nucleosomes are the elementary building blocks. Nucleosomal DNA is wrapped around a…”
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Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase by Petzold, Georg, Fischer, Eric S, Thomä, Nicolas H

“…Thalidomide and its derivatives, lenalidomide and pomalidomide, are immune modulatory drugs (IMiDs) used in the treatment of haematologic malignancies. IMiDs…”
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Rational discovery of molecular glue degraders via scalable chemical profiling by Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.

“…Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of…”
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Crystal structure of the human COP9 signalosome by Lingaraju, Gondichatnahalli M., Bunker, Richard D., Cavadini, Simone, Hess, Daniel, Hassiepen, Ulrich, Renatus, Martin, Fischer, Eric S., Thomä, Nicolas H.

“…Ubiquitination is a crucial cellular signalling process, and is controlled on multiple levels. Cullin–RING E3 ubiquitin ligases (CRLs) are regulated by the…”
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Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing by Ninan, Neethu, Forget, Aurelien, Shastri, V. Prasad, Voelcker, Nicolas H, Blencowe, Anton

“…pH-sensitive hydrogels play an important role in controlled drug release applications and have the potential to impact the management of wounds. In this study,…”
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From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation by Oleinikovas, Vladas, Gainza, Pablo, Ryckmans, Thomas, Fasching, Bernhard, Thomä, Nicolas H

“…Thalidomide and its derivatives are powerful cancer therapeutics that are among the best-understood molecular glue degraders (MGDs). These drugs selectively…”
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Structural insights into Fe–S protein biogenesis by the CIA targeting complex by Kassube, Susanne A., Thomä, Nicolas H.

“…The cytosolic iron–sulfur (Fe–S) assembly (CIA) pathway is required for the insertion of Fe–S clusters into cytosolic and nuclear client proteins, including…”
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Mechanisms of OCT4-SOX2 motif readout on nucleosomes by Michael, Alicia K, Grand, Ralph S, Isbel, Luke, Cavadini, Simone, Kozicka, Zuzanna, Kempf, Georg, Bunker, Richard D, Schenk, Andreas D, Graff-Meyer, Alexandra, Pathare, Ganesh R, Weiss, Joscha, Matsumoto, Syota, Burger, Lukas, Schübeler, Dirk, Thomä, Nicolas H

“…Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes restrict DNA access. To study how TFs bind nucleosome-occupied motifs…”
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Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges by Zhang, Weisen, Mehta, Ami, Tong, Ziqiu, Esser, Lars, Voelcker, Nicolas H.

“…Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to treat with current drugs as their delivery efficacy to the brain…”
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A MACEing silicon: Towards single-step etching of defined porous nanostructures for biomedicine by Alhmoud, Hashim, Brodoceanu, Daniel, Elnathan, Roey, Kraus, Tobias, Voelcker, Nicolas H.

“…Metal-assisted chemical etching (MACE) affords porous silicon nanostructures control over size, shape, and porosity in a single step. Simplicity and…”
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Gold microneedles fabricated by casting of gold ink used for urea sensing by Senel, Mehmet, Dervisevic, Muamer, Voelcker, Nicolas H.

“…•Simple and effective fabrication method of an array of gold microneedles.•Structural and electrochemical characterisation of gold microneedles.•Demonstration…”
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Pioneer factors: Emerging rules of engagement for transcription factors on chromatinized DNA by Carminati, Manuel, Vecchia, Luca, Stoos, Lisa, Thomä, Nicolas H.

“…Pioneering transcription factors (TFs) can drive cell fate changes by binding their DNA motifs in a repressive chromatin environment. Recent structures…”
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Nanoporous anodic aluminium oxide: Advances in surface engineering and emerging applications by JANI, Abdul Mutalib Md, LOSIC, Dusan, VOELCKER, Nicolas H

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Skin in the diagnostics game: Wearable biosensor nano- and microsystems for medical diagnostics by Dervisevic, Muamer, Alba, Maria, Prieto-Simon, Beatriz, Voelcker, Nicolas H.

“…[Display omitted] •Skin biofluids contain a wealth of molecular information related to an individual’s health and wellbeing state.•These biofluids (i.e. sweat,…”
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Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes by Ostapcuk, Veronika, Mohn, Fabio, Carl, Sarah H., Basters, Anja, Hess, Daniel, Iesmantavicius, Vytautas, Lampersberger, Lisa, Flemr, Matyas, Pandey, Aparna, Thomä, Nicolas H., Betschinger, Joerg, Bühler, Marc

“…De novo mutations in ADNP , which encodes activity-dependent neuroprotective protein (ADNP), have recently been found to underlie Helsmoortel–Van der Aa…”
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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K by Słabicki, Mikołaj, Kozicka, Zuzanna, Petzold, Georg, Li, Yen-Der, Manojkumar, Manisha, Bunker, Richard D., Donovan, Katherine A., Sievers, Quinlan L., Koeppel, Jonas, Suchyta, Dakota, Sperling, Adam S., Fink, Emma C., Gasser, Jessica A., Wang, Li R., Corsello, Steven M., Sellar, Rob S., Jan, Max, Gillingham, Dennis, Scholl, Claudia, Fröhling, Stefan, Golub, Todd R., Fischer, Eric S., Thomä, Nicolas H., Ebert, Benjamin L.

“…Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation 1 . Unlike traditional…”
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