Search Results - "Nicolaou, K. C."

The Role of Organic Synthesis in the Emergence and Development of Antibody–Drug Conjugates as Targeted Cancer Therapies by Nicolaou, K. C., Rigol, Stephan

“…With a number of antibody–drug conjugates (ADCs) approved for clinical use as targeted cancer therapies and numerous candidates in clinical trials, the field…”
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Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine by Nicolaou, K C, Rigol, Stephan

“…Covering: 1970 to 2020By definition total synthesis is the art and science of making the molecules of living Nature in the laboratory, and by extension, their…”
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Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory by Nicolaou, K. C.

“…Synthetic organic chemists have the power to replicate some of the most intriguing molecules of living nature in the laboratory and apply their developed…”
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The art of total synthesis through cascade reactions by Nicolaou, K C, Chen, Jason S

“…The growing importance of cascade reactions reflects and imparts advances in the state of the art of organic synthesis and underscores the desire of synthetic…”
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Samarium Diiodide Mediated Reactions in Total Synthesis by Nicolaou, K. C., Ellery, Shelby P., Chen, Jason S.

“…Introduced by Henri Kagan more than three decades ago, samarium diiodide (SmI2) has found increasing application in chemical synthesis. This single‐electron…”
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Total Syntheses of Thailanstatins A–C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents by Nicolaou, K. C, Rhoades, Derek, Kumar, S. Mothish

“…Efficient and selective total syntheses of spliceosome modulating natural products thailan­statins A–C and spliceo­statin D are reported. A number of…”
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Cascade Reactions in Total Synthesis by Nicolaou, K. C., Edmonds, David J., Bulger, Paul G.

“…The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and…”
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Total Synthesis of the Monomeric Unit of Lomaiviticin A by Nicolaou, K. C, Chen, Qifeng, Li, Ruofan, Anami, Yasuaki, Tsuchikama, Kyoji

“…The architecturally symmetrical and synthetically challenging marine natural products lomaiviticins A and B present alluring synthetic targets due to their…”
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Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis by Nicolaou, K. C., Bulger, Paul G., Sarlah, David

“…In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a…”
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Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations by Nicolaou, K. C, Yu, Ruocheng, Lu, Zhaoyong, Alvarez, Fernando G

“…The synthesis of functionalized aromatic compounds is a central theme of research for modern organic chemistry. Despite the increasing finesse in the…”
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Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance by Nicolaou, K C, Hale, Christopher R H, Nilewski, Christian, Ioannidou, Heraklidia A

“…The advent of organic synthesis and the understanding of the molecule as they occurred in the nineteenth century and were refined in the twentieth century…”
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Addressing the Stereochemistry of Complex Organic Molecules by Density Functional Theory-NMR: Vannusal B in Retrospective by Saielli, Giacomo, Nicolaou, K. C, Ortiz, Adrian, Zhang, Hongjun, Bagno, Alessandro

“…We have employed density functional theory (DFT) protocols to calculate the NMR properties of the vannusals, a class of natural products whose structures have…”
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Metathesis Reactions in Total Synthesis by Nicolaou, K. C., Bulger, Paul G., Sarlah, David

“…With the exception of palladium‐catalyzed cross‐couplings, no other group of reactions has had such a profound impact on the formation of carbon–carbon bonds…”
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Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates by Nicolaou, K. C, Erande, Rohan D, Yin, Jun, Vourloumis, Dionisios, Aujay, Monette, Sandoval, Joseph, Munneke, Stefan, Gavrilyuk, Julia

“…Improved, streamlined total syntheses of natural tubulysins such as V (Tb45) and U (Tb46) and pretubulysin D (PTb-D43), and their application to the synthesis…”
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A Reverse Approach to the Total Synthesis of Halichondrin B by Nicolaou, K. C, Pan, Saiyong, Shelke, Yogesh, Das, Dipendu, Ye, Qiuji, Lu, Yong, Sau, Susanta, Bao, Ruiyang, Rigol, Stephan

“…A new strategy is described for the total synthesis of halichondrin B featuring reversal of the sequential construction of a number of its cyclic ethers from…”
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Enantioselective Dichlorination of Allylic Alcohols by Nicolaou, K. C, Simmons, Nicholas L, Ying, Yongcheng, Heretsch, Philipp M, Chen, Jason S

“…The development of an enantioselective allylic alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododichlorides as…”
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Total Syntheses of Anominine and Tubingensin A by Bian, Ming, Wang, Zhen, Xiong, Xiaochun, Sun, Yu, Matera, Carlo, Nicolaou, K. C, Li, Ang

“…A divergent strategy for the total syntheses of the indole terpenoid anominine (1) and its natural congener tubingensin A (2) has been developed. The common…”
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Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins by Nicolaou, K. C, Yin, Jun, Mandal, Debashis, Erande, Rohan D, Klahn, Philipp, Jin, Michael, Aujay, Monette, Sandoval, Joseph, Gavrilyuk, Julia, Vourloumis, Dionisios

“…A streamlined total synthesis of N 14-desacetoxytubulysin H (Tb1) based on a C–H activation strategy and a short total synthesis of pretubulysin D (PTb-D43)…”
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Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics by Nicolaou, K. C, Das, Dipendu, Lu, Yong, Rout, Subhrajit, Pitsinos, Emmanuel N, Lyssikatos, Joseph, Schammel, Alexander, Sandoval, Joseph, Hammond, Mikhail, Aujay, Monette, Gavrilyuk, Julia

“…The family of anthra­quinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded,…”
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12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents by Nicolaou, K. C, Rhoades, Derek, Wang, Yanping, Bai, Ruoli, Hamel, Ernest, Aujay, Monette, Sandoval, Joseph, Gavrilyuk, Julia

“…The synthesis and biological evaluation of a series of 12,13-aziridinyl epothilone B analogues is described. These compounds were accessed by a practical,…”
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