Search Results - "Nicolai, Leo"

Platelets as key players in inflammation and infection by Nicolai, Leo, Massberg, Steffen

“…PURPOSE OF REVIEWThis review highlights recent insights into the role of platelets in acute inflammation and infection. RECENT FINDINGSPlatelets exhibit…”
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Neutrophil-Platelet Interactions as Novel Treatment Targets in Cardiovascular Disease by Kaiser, Rainer, Escaig, Raphael, Erber, Johanna, Nicolai, Leo

“…Neutrophils and platelets are among the most abundant cell types in peripheral blood and characterized by high plasticity and a readily available reservoir of…”
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Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1 by Petzold, Tobias, Thienel, Manuela, Dannenberg, Lisa, Mourikis, Philipp, Helten, Carolin, Ayhan, Aysel, M’Pembele, René, Achilles, Alina, Trojovky, Kajetan, Konsek, Daniel, Zhang, Zhe, Regenauer, Ron, Pircher, Joachim, Ehrlich, Andreas, Lüsebrink, Enzo, Nicolai, Leo, Stocker, Thomas J., Brandl, Richard, Röschenthaler, Franz, Strecker, Jan, Saleh, Inas, Spannagl, Michael, Mayr, Christoph H., Schiller, Herbert B., Jung, Christian, Gerdes, Norbert, Hoffmann, Till, Levkau, Bodo, Hohlfeld, Thomas, Zeus, Tobias, Schulz, Christian, Kelm, Malte, Polzin, Amin

“…A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban…”
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Vascular surveillance by haptotactic blood platelets in inflammation and infection by Nicolai, Leo, Schiefelbein, Karin, Lipsky, Silvia, Leunig, Alexander, Hoffknecht, Marie, Pekayvaz, Kami, Raude, Ben, Marx, Charlotte, Ehrlich, Andreas, Pircher, Joachim, Zhang, Zhe, Saleh, Inas, Marel, Anna-Kristina, Löf, Achim, Petzold, Tobias, Lorenz, Michael, Stark, Konstantin, Pick, Robert, Rosenberger, Gerhild, Weckbach, Ludwig, Uhl, Bernd, Xia, Sheng, Reichel, Christoph Andreas, Walzog, Barbara, Schulz, Christian, Zheden, Vanessa, Bender, Markus, Li, Rong, Massberg, Steffen, Gaertner, Florian

“…Breakdown of vascular barriers is a major complication of inflammatory diseases. Anucleate platelets form blood-clots during thrombosis, but also play a…”
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Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo by Nicolai, Leo, Kaiser, Rainer, Escaig, Raphael, Hoffknecht, Marie-Louise, Anjum, Afra, Leunig, Alexander, Pircher, Joachim, Ehrlich, Andreas, Lorenz, Michael, Ishikawa-Ankerhold, Hellen, Aird, William C., Massberg, Steffen, Gaertner, Florian

“…Visualizing cell behavior and effector function on a single cell level has been crucial for understanding key aspects of mammalian biology. Due to their small…”
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Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion by Eser, Tabea M., Baranov, Olga, Huth, Manuel, Ahmed, Mohammed I. M., Deák, Flora, Held, Kathrin, Lin, Luming, Pekayvaz, Kami, Leunig, Alexander, Nicolai, Leo, Pollakis, Georgios, Buggert, Marcus, Price, David A., Rubio-Acero, Raquel, Reich, Jakob, Falk, Philine, Markgraf, Alissa, Puchinger, Kerstin, Castelletti, Noemi, Olbrich, Laura, Vanshylla, Kanika, Klein, Florian, Wieser, Andreas, Hasenauer, Jan, Kroidl, Inge, Hoelscher, Michael, Geldmacher, Christof

“…Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components of the early immune response protect against…”
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Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection by Pekayvaz, Kami, Leunig, Alexander, Kaiser, Rainer, Joppich, Markus, Brambs, Sophia, Janjic, Aleksandar, Popp, Oliver, Nixdorf, Daniel, Fumagalli, Valeria, Schmidt, Nora, Polewka, Vivien, Anjum, Afra, Knottenberg, Viktoria, Eivers, Luke, Wange, Lucas E., Gold, Christoph, Kirchner, Marieluise, Muenchhoff, Maximilian, Hellmuth, Johannes C., Scherer, Clemens, Rubio-Acero, Raquel, Eser, Tabea, Deák, Flora, Puchinger, Kerstin, Kuhl, Niklas, Linder, Andreas, Saar, Kathrin, Tomas, Lukas, Schulz, Christian, Wieser, Andreas, Enard, Wolfgang, Kroidl, Inge, Geldmacher, Christof, von Bergwelt-Baildon, Michael, Keppler, Oliver T., Munschauer, Mathias, Iannacone, Matteo, Zimmer, Ralf, Mertins, Philipp, Hubner, Norbert, Hoelscher, Michael, Massberg, Steffen, Stark, Konstantin, Nicolai, Leo

“…The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective…”
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Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19 by Kaiser, Rainer, Leunig, Alexander, Pekayvaz, Kami, Popp, Oliver, Joppich, Markus, Polewka, Vivien, Escaig, Raphael, Anjum, Afra, Hoffknecht, Marie-Louise, Gold, Christoph, Brambs, Sophia, Engel, Anouk, Stockhausen, Sven, Knottenberg, Viktoria, Titova, Anna, Haji, Mohamed, Scherer, Clemens, Muenchhoff, Maximilian, Hellmuth, Johannes C, Saar, Kathrin, Schubert, Benjamin, Hilgendorff, Anne, Schulz, Christian, Kääb, Stefan, Zimmer, Ralf, Hübner, Norbert, Massberg, Steffen, Mertins, Philipp, Nicolai, Leo, Stark, Konstantin

“…Neutrophils provide a critical line of defense in immune responses to various pathogens, inflicting self-damage upon transition to a hyperactivated,…”
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Author Correction: Vascular surveillance by haptotactic blood platelets in inflammation and infection by Nicolai, Leo, Schiefelbein, Karin, Lipsky, Silvia, Leunig, Alexander, Hoffknecht, Marie, Pekayvaz, Kami, Raude, Ben, Marx, Charlotte, Ehrlich, Andreas, Pircher, Joachim, Zhang, Zhe, Saleh, Inas, Marel, Anna-Kristina, Löf, Achim, Petzold, Tobias, Lorenz, Michael, Stark, Konstantin, Pick, Robert, Rosenberger, Gerhild, Weckbach, Ludwig, Uhl, Bernd, Xia, Sheng, Reichel, Christoph Andreas, Walzog, Barbara, Schulz, Christian, Zheden, Vanessa, Bender, Markus, Li, Rong, Massberg, Steffen, Gaertner, Florian

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Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets by Sisario, Dmitri, Spindler, Markus, Ermer, Katharina J, Grütz, Noah, Nicolai, Leo, Gaertner, Florian, Machesky, Laura M, Bender, Markus

“…Platelet function at vascular injury sites is tightly regulated through the actin cytoskeleton. The Wiskott-Aldrich syndrome protein-family…”
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Myeloid cells take ischemic insult to heart by Nicolai, Leo, Massberg, Steffen

“…Morbidity and mortality associated with stroke cannot be attributed solely to the acute ischemic event, but are also rooted in long-term complications,…”
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Thromboinflammation in long COVID—the elusive key to postinfection sequelae? by Nicolai, Leo, Kaiser, Rainer, Stark, Konstantin

“…Long COVID is a public health emergency affecting millions of people worldwide, characterized by heterogeneous symptoms across multiple organ systems. Here, we…”
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Hemostasis without clot formation: how platelets guard the vasculature in inflammation, infection, and malignancy by Kaiser, Rainer, Escaig, Raphael, Nicolai, Leo

“…[Display omitted] Platelets are key vascular effectors in hemostasis, with activation signals leading to fast recruitment, aggregation, and clot formation. The…”
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Platelets in Host Defense: Experimental and Clinical Insights by Nicolai, Leo, Gaertner, Florian, Massberg, Steffen

“…Platelets are central players in thrombosis and hemostasis but are increasingly recognized as key components of the immune system. They shape ensuing immune…”
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Platelets: Orchestrators of immunity in host defense and beyond by Nicolai, Leo, Pekayvaz, Kami, Massberg, Steffen

“…Platelets prevent blood loss during vascular injury and contribute to thrombus formation in cardiovascular disease. Beyond these classical roles, platelets are…”
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Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy by Nicolai, Leo, Leunig, Alexander, Brambs, Sophia, Kaiser, Rainer, Weinberger, Tobias, Weigand, Michael, Muenchhoff, Maximilian, Hellmuth, Johannes C., Ledderose, Stephan, Schulz, Heiko, Scherer, Clemens, Rudelius, Martina, Zoller, Michael, Höchter, Dominik, Keppler, Oliver, Teupser, Daniel, Zwißler, Bernhard, von Bergwelt-Baildon, Michael, Kääb, Stefan, Massberg, Steffen, Pekayvaz, Kami, Stark, Konstantin

“…Severe acute respiratory syndrome corona virus 2 infection causes severe pneumonia (coronavirus disease 2019 [COVID-19]), but the mechanisms of subsequent…”
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Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria by Gaertner, Florian, Ahmad, Zerkah, Rosenberger, Gerhild, Fan, Shuxia, Nicolai, Leo, Busch, Benjamin, Yavuz, Gökce, Luckner, Manja, Ishikawa-Ankerhold, Hellen, Hennel, Roman, Benechet, Alexandre, Lorenz, Michael, Chandraratne, Sue, Schubert, Irene, Helmer, Sebastian, Striednig, Bianca, Stark, Konstantin, Janko, Marek, Böttcher, Ralph T., Verschoor, Admar, Leon, Catherine, Gachet, Christian, Gudermann, Thomas, Mederos y Schnitzler, Michael, Pincus, Zachary, Iannacone, Matteo, Haas, Rainer, Wanner, Gerhard, Lauber, Kirsten, Sixt, Michael, Massberg, Steffen

“…Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune responses. Despite these versatile tasks in mammalian biology,…”
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Mechanosensing Via a Gp2b3a-Src-Axis Regulates Platelet Migration in Vitro and In Vivo by Nicolai, Leo, Kaiser, Rainer, Loew, Quentin, Kammerer, Lisa, Spiekermann, Karsten, Massberg, Steffen

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Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps by Marx, Charlotte, Novotny, Julia, Salbeck, Danby, Zellner, Katie R., Nicolai, Leo, Pekayvaz, Kami, Kilani, Badr, Stockhausen, Sven, Bürgener, Niklas, Kupka, Danny, Stocker, Thomas J., Weckbach, Ludwig T., Pircher, Joachim, Moser, Markus, Joner, Michael, Desmet, Walter, Adriaenssens, Tom, Neumann, Franz-Josef, Gerschlick, Anthony H., ten Berg, Jurrien M., Lorenz, Michael, Stark, Konstantin

“…Clinical observations implicate a role of eosinophils in cardiovascular diseases because markers of eosinophil activation are elevated in atherosclerosis and…”
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Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease by Losert, Corinna, Pekayvaz, Kami, Knottenberg, Viktoria, Nicolai, Leo, Stark, Konstantin, Heinig, Matthias

“…Disease mechanisms are usually complex and governed by the interaction of several distinct molecular processes. Complex, multidimensional datasets are a…”
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