Search Results - "Nicola N. Lynskey"

Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study by Lynskey, Nicola N, Jauneikaite, Elita, Li, Ho Kwong, Zhi, Xiangyun, Turner, Claire E, Mosavie, Mia, Pearson, Max, Asai, Masanori, Lobkowicz, Ludmila, Chow, J Yimmy, Parkhill, Julian, Lamagni, Theresa, Chalker, Victoria J, Sriskandan, Shiranee

“…Since 2014, England has seen increased scarlet fever activity unprecedented in modern times. In 2016, England's scarlet fever seasonal rise coincided with an…”
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Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase by Lynskey, Nicola N, Reglinski, Mark, Calay, Damien, Siggins, Matthew K, Mason, Justin C, Botto, Marina, Sriskandan, Shiranee

“…The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the…”
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Methylome-dependent transformation of emm1 group A streptococci by Alves, Joana, Rand, Joshua D, Johnston, Alix B E, Bowen, Connor, Lynskey, Nicola N

“…Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group A…”
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Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection by Siggins, Matthew K., Lynskey, Nicola N., Lamb, Lucy E., Johnson, Louise A., Huse, Kristin K., Pearson, Max, Banerji, Suneale, Turner, Claire E., Woollard, Kevin, Jackson, David G., Sriskandan, Shiranee

“…Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus…”
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RocA truncation underpins hyper-encapsulation, carriage longevity and transmissibility of serotype M18 group A streptococci by Lynskey, Nicola N, Goulding, David, Gierula, Magdalena, Turner, Claire E, Dougan, Gordon, Edwards, Robert J, Sriskandan, Shiranee

“…Group A streptococcal isolates of serotype M18 are historically associated with epidemic waves of pharyngitis and the non-suppurative immune sequela rheumatic…”
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Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction by Lynskey, Nicola N, Banerji, Suneale, Johnson, Louise A, Holder, Kayla A, Reglinski, Mark, Wing, Peter A C, Rigby, David, Jackson, David G, Sriskandan, Shiranee

“…The host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a…”
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Flow Cytometry-Based Assays to Quantify Complement Deposition and Neutrophil Uptake of Group A Streptococcus by Lynskey, Nicola N

“…Quantification of complement deposition and subsequent neutrophil-mediated uptake provides an important way to assess the role of different bacterial factors…”
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Generation of tools for expression and purification of the phage-encoded Type I restriction enzyme inhibitor, Ocr by Alves, Joana, Dry, Inga, White, John H, Dryden, David T F, Lynskey, Nicola N

“…DNA manipulation is an essential tool in molecular microbiology research that is dependent on the ability of bacteria to take up and preserve foreign DNA by…”
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Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation by Reglinski, Mark, Lynskey, Nicola N., Sriskandan, Shiranee

“…The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes research. Modification of the Lancefield assay to include an…”
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Structure of the Streptococcus pyogenes NAD + Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes by Velarde, Jorge J, Piai, Alessandro, Lichtenstein, Ian J, Lynskey, Nicola N, Chou, James J, Wessels, Michael R

“…The emergence and continued dominance of a Streptococcus pyogenes (group A Streptococcus, GAS) M1T1 clonal group is temporally correlated with acquisition of…”
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Methylome-dependent transformation of emm 1 group A streptococci by Alves, Joana, Rand, Joshua D, Johnston, Alix B E, Bowen, Connor, Lynskey, Nicola N

“…Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group A (GAS), a…”
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Identification of the Streptococcus pyogenes surface antigens recognised by pooled human immunoglobulin by Reglinski, Mark, Gierula, Magdalena, Lynskey, Nicola N., Edwards, Robert J., Sriskandan, Shiranee

“…Immunity to common bacteria requires the generation of antibodies that promote opsonophagocytosis and neutralise toxins. Pooled human immunoglobulin is widely…”
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Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG by Reglinski, Mark, Lynskey, Nicola N, Choi, Yoon Jung, Edwards, Robert J, Sriskandan, Shiranee

“…Summary Objectives Despite over a century of research and the careful scrutiny of many promising targets, there is currently no vaccine available for the…”
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Identification of commonly expressed exoproteins and proteolytic cleavage events by proteomic mining of clinically relevant UK isolates of Staphylococcus aureus by Smith, Debra S, Siggins, Matthew K, Gierula, Magdalena, Pichon, Bruno, Turner, Claire E, Lynskey, Nicola N, Mosavie, Mia, Kearns, Angela M, Edwards, Robert J, Sriskandan, Shiranee

“…The range of exoproteins and core exoproteome of 14 isolates representing major lineages associated with asymptomatic carriage and clinical disease in the UK…”
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RocA Binds CsrS To Modulate CsrRS-Mediated Gene Regulation in Group A Streptococcus by Lynskey, Nicola N, Velarde, Jorge J, Finn, Meredith B, Dove, Simon L, Wessels, Michael R

“…The orphan regulator RocA plays a critical role in the colonization and pathogenesis of the obligate human pathogen group A Despite multiple lines of evidence…”
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New understandings in Streptococcus pyogenes by Lynskey, Nicola N, Lawrenson, Richard A, Sriskandan, Shiranee

“…PURPOSE OF REVIEWA resurgence of invasive group A streptococcal infections highlights the need for better knowledge of streptococcal biology. This review…”
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RocA Binds CsrS To Modulate CsrRS-Mediated Gene Regulation in Group A italic toggle="yes">Streptococcus /italic by Nicola N. Lynskey, Jorge J. Velarde, Meredith B. Finn, Simon L. Dove, Michael R. Wessels

“…ABSTRACT The orphan regulator RocA plays a critical role in the colonization and pathogenesis of the obligate human pathogen group A Streptococcus. Despite…”
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Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction: e1005137 by Lynskey, Nicola N, Banerji, Suneale, Johnson, Louise A, Holder, Kayla A, Reglinski, Mark, Wing, Peter AC, Rigby, David, Jackson, David G, Sriskandan, Shiranee

“…The host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a…”
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RocA Truncation Underpins Hyper-Encapsulation, Carriage Longevity and Transmissibility of Serotype M18 Group A Streptococci: e1003842 by Lynskey, Nicola N, Goulding, David, Gierula, Magdalena, Turner, Claire E, Dougan, Gordon, Edwards, Robert J, Sriskandan, Shiranee

“…Group A streptococcal isolates of serotype M18 are historically associated with epidemic waves of pharyngitis and the non-suppurative immune sequela rheumatic…”
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