Search Results - "Nicola, Juan Pablo"

A Carboxy-Terminal Monoleucine-Based Motif Participates in the Basolateral Targeting of the Na+/I− Symporter by Martín, Mariano, Modenutti, Carlos Pablo, Peyret, Victoria, Geysels, Romina Celeste, Darrouzet, Elisabeth, Pourcher, Thierry, Masini-Repiso, Ana María, Martí, Marcelo Adrián, Carrasco, Nancy, Nicola, Juan Pablo

“…Abstract The Na+/iodide (I−) symporter (NIS), a glycoprotein expressed at the basolateral plasma membrane of thyroid follicular cells, mediates I− accumulation…”
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The Acute Inhibitory Effect of Iodide Excess on Sodium/Iodide Symporter Expression and Activity Involves the PI3K/Akt Signaling Pathway by Serrano-Nascimento, Caroline, da Silva Teixeira, Silvania, Nicola, Juan Pablo, Nachbar, Renato Tadeu, Masini-Repiso, Ana Maria, Nunes, Maria Tereza

“…Iodide (I−) is an irreplaceable constituent of thyroid hormones and an important regulator of thyroid function, because high concentrations of I− down-regulate…”
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A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis by Martín, Mariano, Modenutti, Carlos Pablo, Gil Rosas, Mauco Lucas, Peyret, Victoria, Geysels, Romina Celeste, Bernal Barquero, Carlos Eduardo, Sobrero, Gabriela, Muñoz, Liliana, Signorino, Malvina, Testa, Graciela, Miras, Mirta Beatriz, Masini-Repiso, Ana María, Calcaterra, Nora Beatriz, Coux, Gabriela, Carrasco, Nancy, Martí, Marcelo Adrián, Nicola, Juan Pablo

“…Abstract Context Iodide transport defect (ITD) (Online Mendelian Inheritance in Man No. 274400) is an uncommon cause of dyshormonogenic congenital…”
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The Response of Prostate Smooth Muscle Cells to Testosterone Is Determined by the Subcellular Distribution of the Androgen Receptor by Peinetti, Nahuel, Scalerandi, María Victoria, Cuello Rubio, Mariana Micaela, Leimgruber, Carolina, Nicola, Juan Pablo, Torres, Alicia Ines, Quintar, Amado Alfredo, Maldonado, Cristina Alicia

“…Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of prostate homeostasis, the alterations of which are a central…”
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Neonatal endotoxin stimulation is associated with a long-term bronchiolar epithelial expression of innate immune and anti-allergic markers that attenuates the allergic response by García, Luciana Noemi, Leimgruber, Carolina, Nicola, Juan Pablo, Quintar, Amado Alfredo, Maldonado, Cristina Alicia

“…Allergic asthma is the most common phenotype of the pathology, having an early-onset in childhood and producing a Th2-driven airways remodeling process that…”
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Testosterone-loaded GM1 micelles targeted to the intracellular androgen receptor for the specific induction of genomic androgen signaling by Peinetti, Nahuel, Cuello Rubio, Mariana Micaela, Sosa, Liliana Del Valle, Scalerandi, María Victoria, Alasino, Roxana Valeria, Peyret, Victoria, Nicola, Juan Pablo, Beltramo, Dante Miguel, Quintar, Amado Alfredo, Maldonado, Cristina Alicia

“…[Display omitted] •Testosterone can be loaded into GM1 micelles for delivery into the cytoplasm.•Testosterone-loaded micelles are specific modulators of…”
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Targeted Next-Generation Sequencing of Congenital Hypothyroidism-Causative Genes Reveals Unexpected Thyroglobulin Gene Variants in Patients with Iodide Transport Defect by Bernal Barquero, Carlos Eduardo, Geysels, Romina Celeste, Jacques, Virginie, Carro, Gerardo Hernán, Martín, Mariano, Peyret, Victoria, Abregú, María Celeste, Papendieck, Patricia, Masini-Repiso, Ana María, Savagner, Frédérique, Chiesa, Ana Elena, Citterio, Cintia E, Nicola, Juan Pablo

“…Congenital iodide transport defect is an uncommon autosomal recessive disorder caused by loss-of-function variants in the sodium iodide symporter (NIS)-coding…”
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S-Nitrosylation of NF-κB p65 Inhibits TSH-Induced Na+/I− Symporter Expression by Nicola, Juan Pablo, Peyret, Victoria, Nazar, Magalí, Romero, Jorge Miguel, Lucero, Ariel Maximiliano, Montesinos, María del Mar, Bocco, José Luis, Pellizas, Claudia Gabriela, Masini-Repiso, Ana María

“…Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase…”
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Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells by Di Giusto, Pablo, Martín, Mariano, Funes Chabán, Macarena, Sampieri, Luciana, Nicola, Juan Pablo, Alvarez, Cecilia

“…The transcription factor CREB3L1 is expressed in a wide variety of tissues including cartilage, pancreas, and bone. It is located in the endoplasmic reticulum…”
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Thyroid Peroxidase Gene Expression Is Induced by Lipopolysaccharide Involving Nuclear Factor (NF)-κB p65 Subunit Phosphorylation by Nazar, Magalí, Nicola, Juan Pablo, Vélez, María Laura, Pellizas, Claudia Gabriela, Masini-Repiso, Ana María

“…Thyroid peroxidase (TPO), a tissue-specific enzyme expressed in differentiated thyroid follicular cells, is a major antigen that has been linked to autoimmune…”
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Impact of the Mutational Landscape of the Sodium/Iodide Symporter in Congenital Hypothyroidism by Martín, Mariano, Nicola, Juan Pablo

“…Iodide transport defect is an uncommon cause of dyshormonogenic congenital hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the…”
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Functional Toll-Like Receptor 4 Conferring Lipopolysaccharide Responsiveness Is Expressed in Thyroid Cells by Nicola, Juan Pablo, Vélez, María Laura, Lucero, Ariel Maximiliano, Fozzatti, Laura, Pellizas, Claudia Gabriela, Masini-Repiso, Ana María

“…Lipopolysaccharide (LPS), a glycolipid found in the cell wall of Gram-negative bacteria, exerts pleiotropic biological effects in different cell types. LPS is…”
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Editorial: New molecular pathways in thyroid cancer and pathophysiology: role of coding and noncoding genes by Fuziwara, Cesar Seigi, Nicola, Juan Pablo, Geraldo, Murilo Vieira

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Sodium iodide symporter-targeted gene therapy in glioblastoma by Nicola, Juan Pablo, LaRocca, Christopher J.

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The Na+/I- symporter mediates active iodide uptake in the intestine by Nicola, Juan Pablo, Basquin, Cécile, Portulano, Carla, Reyna-Neyra, Andrea, Paroder, Monika, Carrasco, Nancy

“…Absorption of dietary iodide, presumably in the small intestine, is the first step in iodide (I(-)) utilization. From the bloodstream, I(-) is actively taken…”
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Secreted Factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism by Stempin, Cinthia Carolina, Geysels, Romina Celeste, Park, Sunmi, Palacios, Luz Maria, Volpini, Ximena, Motran, Claudia Cristina, Acosta Rodríguez, Eva Virginia, Nicola, Juan Pablo, Cheng, Sheue-yann, Pellizas, Claudia Gabriela, Fozzatti, Laura

“…Anaplastic thyroid cancer (ATC) is a highly aggressive type of thyroid cancer (TC). Currently, no effective target treatments are available that can improve…”
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Dietary I(-) absorption: expression and regulation of the Na(+)/I(-) symporter in the intestine by Nicola, Juan Pablo, Carrasco, Nancy, Masini-Repiso, Ana María

“…Thyroid hormones are critical for the normal development, growth, and functional maturation of several tissues, including the central nervous system. Iodine is…”
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Dietary iodide controls its own absorption through post‐transcriptional regulation of the intestinal Na+/I− symporter by Nicola, Juan Pablo, Reyna‐Neyra, Andrea, Carrasco, Nancy, Masini‐Repiso, Ana Maria

“…Key points •  Expression of the Na+/I− symporter (NIS) at the apical surface of the epithelium of the small intestine is key to I− absorption, the first step…”
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Excess iodide downregulates Na+/I− symporter gene transcription through activation of PI3K/Akt pathway by Serrano-Nascimento, Caroline, Nicola, Juan Pablo, Teixeira, Silvania da Silva, Poyares, Leonice Lourenço, Lellis-Santos, Camilo, Bordin, Silvana, Masini-Repiso, Ana Maria, Nunes, Maria Tereza

“…Transcriptional mechanisms associated with iodide-induced downregulation of NIS expression remain uncertain. Here, we further analyzed the transcriptional…”
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Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels by Montesinos, María del Mar, Nicola, Juan Pablo, Nazar, Magalí, Peyret, Victoria, Lucero, Ariel Maximiliano, Pellizas, Claudia Gabriela, Masini-Repiso, Ana María

“…Thyroid peroxidase (TPO) is essential for thyroid hormone synthesis mediating the covalent incorporation of iodine into tyrosine residues of thyroglobulin…”
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