Search Results - "Nickols, Allen"

Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis by Swiatek, Wojciech, Parnell, K. Mark, Nickols, G. Allen, Scharschmidt, Bruce F., Rutter, Jared

“…Hyperactivation of sterol regulatory element binding protein 1c (SREBP‐1c), which transcriptionally induces expression of enzymes responsible for de novo…”
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PAS Kinase Drives Lipogenesis through SREBP-1 Maturation by Wu, Xiaoying, Romero, Donna, Swiatek, Wojciech I., Dorweiler, Irene, Kikani, Chintan K., Sabic, Hana, Zweifel, Ben S., McKearn, John, Blitzer, Jeremy T., Nickols, G. Allen, Rutter, Jared

“…Elevated hepatic synthesis of fatty acids and triglycerides, driven by hyperactivation of the SREBP-1c transcription factor, has been implicated as a causal…”
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Regulation of Collagenase-3 and Osteocalcin Gene Expression by Collagen and Osteopontin in Differentiating MC3T3-E1 Cells by D'Alonzo, Richard C., Kowalski, Aaron J., Denhardt, David T., Nickols, G. Allen, Partridge, Nicola C.

“…Both collagenase-3 and osteocalcin mRNAs are expressed maximally during the later stages of osteoblast differentiation. Here, we demonstrate that collagenase-3…”
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Parathyroid hormone as a smooth muscle relaxant by Mok, L L, Nickols, G A, Thompson, J C, Cooper, C W

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Bone cell function, regulation, and communication: a role for nitric oxide by Collin-Osdoby, P, Nickols, G A, Osdoby, P

“…A large array of factors serve as vital communication links between cells and the characterization, regulation, and mechanisms of action of such factors are…”
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Reduction in Atherosclerotic Lesion Size in Pigs by αVβ3 Inhibitors Is Associated With Inhibition of Insulin-Like Growth Factor-I–Mediated Signaling by Nichols, Timothy C, Laney, Tracey du, Zheng, Bo, Bellinger, Dwight A, Nickols, G Allen, Engleman, Wayne, Clemmons, David R

“…Insulin-like growth factor-I (IGF-I) is a potent stimulant of smooth muscle cell (SMC) migration and proliferation and has been implicated in the development…”
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Synthetic αVβ3 Antagonists Inhibit Insulin-Like Growth Factor-I-Stimulated Smooth Muscle Cell Migration and Replication by Clemmons, David R, Horvitz, Gayle, Engleman, Wayne, Nichols, Tim, Moralez, Anna, G Allen Nickols

“…Porcine aortic smooth cells respond to insulin-like growth factor-I (IGF-I) with increases in DNA synthesis and cell migration. Because ligand occupancy of the…”
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New evidence for insulin resistance in adult spontaneously hypertensive rat by Yamamoto, Ryuichi, Townsend, Raymond R., Allen Nickols, G., Nickols, Maureen A., DiPette, Donald J., Takasaki, Koichiro

“…Experiments were designed to study the influence of insulin at physiological concentration on pressor responses to periarterial nerve stimulation (PNS) and…”
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Temperature Sensitivity of Cyclic AMP Production and Catecholamine-Induced Refractoriness in a Rat Astrocytoma Cell Line by Nickols, G. Allen, Brooker, Gary

“…Intracellular cyclic AMP was increased more than 100-fold when rat C6-2B astrocytoma cells were treated with isoproterenol in the cold (4 degrees C). When the…”
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Effect of dietary calcium supplementation on blood pressure and calciotropic hormones in mineralocorticoid-salt hypertension by DiPette, D J, Greilich, P E, Nickols, G A, Graham, G A, Green, A, Cooper, C W, Holland, O B

“…In order to determine the effect of dietary calcium supplementation on blood pressure and calciotropic hormones, we studied two groups (n = 12 each) of…”
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A small molecule antagonist of the α v β 3 integrin suppresses MDA-MB-435 skeletal metastasis by Harms, John F., Welch, Danny R., Samant, Rajeev S., Shevde, Lalita A., Miele, Mary E., Babu, Geetha R., Goldberg, Steven F., Gilman, Virginia R., Sosnowski, Donna M., Campo, Dianalee A., Gay, Carol V., Budgeon, Lynn R., Mercer, Robin, Jewell, Jennifer, Mastro, Andrea M., Donahue, Henry J., Erin, Nuray, Debies, Michael T., Meehan, William J., Jones, Amy L., Mbalaviele, Gabriel, Nickols, Allen, Christensen, Neil D., Melly, Robert, Beck, Lisa N., Kent, Julia, Rader, Randall K., Kotyk, John J., Pagel, M.D., Westlin, William F., Griggs, David W.

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A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis by Harms, John F, Welch, Danny R, Samant, Rajeev S, Shevde, Lalita A, Miele, Mary E, Babu, Geetha R, Goldberg, Steven F, Gilman, Virginia R, Sosnowski, Donna M, Campo, Dianalee A, Gay, Carol V, Budgeon, Lynn R, Mercer, Robin, Jewell, Jennifer, Mastro, Andrea M, Donahue, Henry J, Erin, Nuray, Debies, Michael T, Meehan, William J, Jones, Amy L, Mbalaviele, Gabriel, Nickols, Allen, Christensen, Neil D, Melly, Robert, Beck, Lisa N, Kent, Julia, Rader, Randall K, Kotyk, John J, Pagel, M D, Westlin, William F, Griggs, David W

“…Breast cancer is one of the most common malignancies affecting women in the United States and Europe. Approximately three out of every four women with breast…”
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Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists by PENNING, Thomas D, KHILEVICH, Albert, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, RADER, Randall K, SETTLE, Steven L, SHANNON, Kristen E, STEININGER, Christina N, WESTLIN, Marisa M, CHEN, Barbara B, WESTLIN, William F, RUSSELL, Mark A, BOYS, Mark L, YAPING WANG, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary Beth, FREEMAN, Sandra K

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Selective inhibition of the inducible nitric oxide synthase by aminoguanidine by Misko, T P, Moore, W M, Kasten, T P, Nickols, G A, Corbett, J A, Tilton, R G, McDaniel, M L, Williamson, J R, Currie, M G

“…Overproduction of the free radical nitric oxide (NO) has been implicated in the pathogenesis of a variety of inflammatory and immunologically mediated diseases…”
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Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists by BOYS, Mark L, SCHRETZMAN, Lori A, STENMARK, Heather G, HONGWEI WU, SPANGLER, Dale P, CLARE, Michael, DESAI, Bipin N, KHANNA, Ish K, NGUYEN, Maria N, DUFFIN, Tiffany, WAYNE ENGLEMAN, V, FINN, Mary Beth, CHANDRAKUMAR, Nizal S, FREEMAN, Sandra K, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marisa, WESTLIN, William, YU, Yi X, TOLLEFSON, Michael B, YAPING WANG, DALTON, Christopher R, NORRING, Sarah A, MOHLER, Scott B, DOWNS, Victoria L, PENNING, Thomas D, RUSSELL, Mark A, WENDT, John A, CHEN, Barbara B

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Potentiation of Osteoclast Bone-Resorption Activity by Inhibition of Nitric Oxide Synthase by Kasten, Thomas P., Collin-Osdoby, Patricia, Patel, Niraj, Osdoby, Philip, Krukowski, Marilyn, Misko, Thomas P., Settle, Steven L., Currie, Mark G., Nickols, G. Allen

“…We have examined the effects of modulating nitric oxide (NO) levels on osteoclast-mediated bone resorption in vitro and the effects of nitric oxide synthase…”
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Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties by WENDT, John A, HONGWEI WU, KEENE, Jeffery L, WAYNE ENGLEMAN, V, FREEMAN, Sandra K, HANNEKE, Melanie L, SHANNON, Kristen E, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marissa, KLOVER, Jon A, WESTLIN, William, STENMARK, Heather G, NICKOLS, G. Allen, RUSSELL, Mark A, BOYS, Mark L, DOWNS, Victoria L, PENNING, Thomas D, CHEN, Barbara B, YAPING WANG, DUFFIN, Tiffany, FINN, Mary Beth

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Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists by Penning, Thomas D, Khilevich, Albert, Chen, Barbara B, Russell, Mark A, Boys, Mark L, Wang, Yaping, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, G Allen, Nickols, Maureen A, Rader, Randall K, Settle, Steven L, Shannon, Kristen E, Steininger, Christina N, Westlin, Marisa M, Westlin, William F

“…We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha(v)beta3 receptor. Compounds showed low to sub-nanomolar potency against…”
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Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties by Wendt, John A, Wu, Hongwei, Stenmark, Heather G, Boys, Mark L, Downs, Victoria L, Penning, Thomas D, Chen, Barbara B, Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L, Engleman, V Wayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Nickols, Maureen A, Steininger, Christina N, Westlin, Marissa, Klover, Jon A, Westlin, William, Nickols, G Allen, Russell, Mark A

“…We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the…”
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Synthesis of 2,5-thiazole butanoic acids as potent and selective α vβ 3 integrin receptor antagonists with improved oral pharmacokinetic properties by Wendt, John A., Wu, Hongwei, Stenmark, Heather G., Boys, Mark L., Downs, Victoria L., Penning, Thomas D., Chen, Barbara B., Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L., Engleman, V. Wayne, Freeman, Sandra K., Hanneke, Melanie L., Shannon, Kristen E., Nickols, Maureen A., Steininger, Christina N., Westlin, Marissa, Klover, Jon A., Westlin, William, Nickols, G. Allen, Russell, Mark A.

“…A series of 2,5 thiazole containing compounds are described, which are potent antagonists of the integrin α vβ 3 and show selectivity relative to the other…”
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