Search Results - "Nicklin, Martin J. H."

Interleukin-1β Regulates CXCL8 Release and Influences Disease Outcome in Response to Streptococcus pneumoniae, Defining Intercellular Cooperation between Pulmonary Epithelial Cells and Macrophages by MARRIOTT, Helen M, GASCOYNE, Kate A, DOCKRELL, David H, GOWDA, Ravi, GEARY, Ian, NICKLIN, Martin J. H, LANNELLI, Francesco, POZZI, Gianni, MITCHELL, Timothy J, WHYTE, Moira K. B, SABROE, Ian

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin by Partridge, Lynda J., Urwin, Lucy, Nicklin, Martin J. H., James, David C., Green, Luke R., Monk, Peter N.

“…Coronaviruses such as SARS-CoV-2, which is responsible for COVID-19, depend on virus spike protein binding to host cell receptors to cause infection. The…”
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Decreased fat mass in interleukin-1 receptor antagonist-deficient mice : Impact on adipogenesis, food intake, and energy expenditure by SOMM, Emmanuel, HENRICHOT, Elvire, PERNIN, Agnès, JUGE-AUBRY, Cristiana E, MUZZIN, Patrick, DAYER, Jean-Michel, NICKLIN, Martin J. H, MEIER, Christoph A

“…Interleukin (IL)-1 is a regulator of inflammation but is also implicated in the control of energy homeostasis. Because the soluble IL-1 receptor antagonist…”
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The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes by Magne, David, Palmer, Gaby, Barton, Jenny L, Mézin, Francoise, Talabot-Ayer, Dominique, Bas, Sylvette, Duffy, Trevor, Noger, Marcus, Guerne, Pierre-Andre, Nicklin, Martin J H, Gabay, Cem

“…Six novel members of the IL-1 family of cytokines were recently identified, primarily through the use of DNA database searches for IL-1 homologues, and were…”
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Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration by Phillips, Kate Louise Eve, Jordan-Mahy, Nikki, Nicklin, Martin J H, Le Maitre, Christine Lyn

“…Interleukin 1 (IL-1) is potentially important in the pathogenesis of intervertebral disc (IVD) degeneration; increasing production of matrix degradation…”
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Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis by Abdollahi-Roodsaz, Shahla, Joosten, Leo A B, Koenders, Marije I, Devesa, Isabel, Roelofs, Mieke F, Radstake, Timothy R D J, Heuvelmans-Jacobs, Marleen, Akira, Shizuo, Nicklin, Martin J H, Ribeiro-Dias, Fátima, van den Berg, Wim B

“…TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or host-derived ligands found in arthritic joints. Here, we…”
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Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor by SHEPHERD, Joanna, NICKLIN, Martin J. H

“…In mice that lack interleukin-1 receptor antagonist (IL-1ra), transmural inflammation of the elastic arteries develops at sites of turbulent flow. We described…”
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Interleukin‐1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin‐1 receptor antagonist–deficient mice by Koenders, Marije I., Devesa, Isabel, Marijnissen, Renoud J., Abdollahi‐Roodsaz, Shahla, Boots, Annemieke M. H., Walgreen, Birgitte, di Padova, Franco E., Nicklin, Martin J. H., Joosten, Leo A. B., van den Berg, Wim B.

“…Objective Interleukin‐1 receptor antagonist–deficient (IL‐1Ra−/−) mice spontaneously develop an inflammatory and destructive arthritis due to unopposed excess…”
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Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2 by Alsaffar, Fatimah A., Mujamammi, Ahmed H., Aldughaim, Mohammed S.K., Nicklin, Martin J.H., Barker, Michael D.

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Finally, function for “IL-1Fs” by Nicklin, Martin J.H.

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A Sequence-Based Map of the Nine Genes of the Human Interleukin-1 Cluster by Nicklin, Martin J.H, Barton, Jenny L, Nguyen, Minh, FitzGerald, Michael G, Duff, Gordon W, Kornman, Ken

“…Six novel genes encoding proteins with the interleukin (IL)-1 fold have been identified recently. The classical family members are involved in inflammatory…”
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Psoriasis-Like Cutaneous Inflammation in Mice Lacking Interleukin-1 Receptor Antagonist by Shepherd, Joanna, Little, Matthew C., Nicklin, Martin J.H.

“…Interleukin-1 receptor antagonist-deficient (Il1rn-/-) BALB/c mice developed inflammation localized to the skin of the ear pinna in 64% of the cases examined…”
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Toll-like Receptor 2 and 4 (TLR2 and TLR4) Agonists Differentially Regulate Secretory Interleukin-1 Receptor Antagonist Gene Expression in Macrophages by Carl, Virginia S., Brown-Steinke, Kathleen, Nicklin, Martin J.H., Smith, Michael F.

“…Treatment of macrophages with lipopolysaccharide (LPS) from Gram-negative bacteria or peptidoglycan (PGN) from Gram-positive bacteria activates multiple…”
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Proteolytic Processing in the Replication of Polio and Related Viruses by Nicklin, Martin J. H, Toyoda, Haruka, Murray, Michael G, Wimmer, Eckard

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A tissue specific IL‐1 receptor antagonist homolog from the IL‐1 cluster lacks IL‐1, IL‐1ra, IL‐18 and IL‐18 antagonist activities by Barton, Jenny L., Herbst, Ruth, Bosisio, Daniela, Higgins, Lee, Nicklin, Martin J. H.

“…Interleukin (IL)‐1‐like protein 1 (IL‐1L1) is a 155‐amino acid protein that shares 27% identity with IL‐1β and 47% with IL‐1 receptor antagonist (IL‐1ra). A…”
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Implications of the Picornavirus Capsid Structure for Polyprotein Processing by Arnold, Edward, Luo, Ming, Vriend, Gerrit, Rossmann, Michael G., Palmenberg, Ann C., Parks, Griffith D., Martin J. H. Nicklin, Wimmer, Eckard

“…Mature picornaviral proteins are derived by progressive, posttranslational cleavage of a precursor polyprotein. These cleavages play a role in the control of…”
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Poliovirus Polypeptide Precursors: Expression in vitro and Processing by Exogenous 3C and 2A Proteinases by Martin J. H. Nicklin, Krausslich, Hans G., Toyoda, Haruka, Dunn, John J., Wimmer, Eckard

“…Plasmids have been constructed to generate substrates for the study of proteinases 2A and 3C of poliovirus. They contain the P1 (capsomer precursor) region of…”
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Molecular events leading to picornavirus genome replication by Wimmer, E, Kuhn, R J, Pincus, S, Yang, C F, Toyoda, H, Nicklin, M J, Takeda, N

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