Search Results - "Nickerson, Kevin"

B cell-intrinsic TLR9 expression is protective in murine lupus by Tilstra, Jeremy S, John, Shinu, Gordon, Rachael A, Leibler, Claire, Kashgarian, Michael, Bastacky, Sheldon, Nickerson, Kevin M, Shlomchik, Mark J

“…Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have…”
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Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions by Gonzalez, David G, Cote, Christine M, Patel, Jaymin R, Smith, Colin B, Zhang, Yuqi, Nickerson, Kevin M, Zhang, Tingting, Kerfoot, Steven M, Haberman, Ann M

“…We examined the unique contributions of the cytokines IL-21 and IL-4 on germinal center (GC) B cell initiation and subsequent maturation in a murine model…”
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Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus by Leibler, Claire, John, Shinu, Elsner, Rebecca A., Thomas, Kayla B., Smita, Shuchi, Joachim, Stephen, Levack, Russell C., Callahan, Derrick J., Gordon, Rachael A., Bastacky, Sheldon, Fukui, Ryutaro, Miyake, Kensuke, Gingras, Sebastien, Nickerson, Kevin M., Shlomchik, Mark J.

“…In lupus, Toll-like receptor 7 (TLR7) and TLR9 mediate loss of tolerance to RNA and DNA, respectively. Yet, TLR7 promotes disease, while TLR9 protects from…”
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TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus by Nickerson, Kevin M, Christensen, Sean R, Shupe, Jonathan, Kashgarian, Michael, Kim, Daniel, Elkon, Keith, Shlomchik, Mark J

“…Systemic lupus erythematosus is characterized by the production of autoantibodies against nucleic acid-associated Ags. We previously found that Tlr7 was…”
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Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice by Nickerson, Kevin M, Smita, Shuchi, Hoehn, Kenneth B, Marinov, Anthony D, Thomas, Kayla B, Kos, Justin T, Yang, Yi, Bastacky, Sheldon I, Watson, Corey T, Kleinstein, Steven H, Shlomchik, Mark J

“…Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor…”
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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE by Motwani, Mona, McGowan, Jason, Antonovitch, Jennifer, Gao, Kevin MingJie, Jiang, Zhaozhao, Sharma, Shruti, Baltus, Gretchen A, Nickerson, Kevin M, Marshak-Rothstein, Ann, Fitzgerald, Katherine A

“…Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in…”
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B cell-intrinsic Myd88 regulates disease progression in murine lupus by Tilstra, Jeremy S, Kim, Minjung, Gordon, Rachael A, Leibler, Claire, Cosgrove, Haylee A, Bastacky, Sheldon, Nickerson, Kevin M, Shlomchik, Mark J

“…Nucleic acid-specific Toll-like receptors (TLRs) have been implicated in promoting disease pathogenesis in systemic lupus erythematosus (SLE). Whether such…”
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The Type II Anti‐CD20 Antibody Obinutuzumab (GA101) Is More Effective Than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model by Marinov, Anthony D., Wang, Haowei, Bastacky, Sheldon I., Puijenbroek, Erwin, Schindler, Thomas, Speziale, Dario, Perro, Mario, Klein, Christian, Nickerson, Kevin M., Shlomchik, Mark J.

“…Objective Depleting pathogenic B cells could treat systemic lupus erythematosus (SLE). However, depleting B cells in an inflammatory setting such as lupus is…”
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Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model by Gordon, Rachael A, Tilstra, Jeremy S, Marinov, Anthony, Nickerson, Kevin M, Bastacky, Sheldon I, Shlomchik, Mark J

“…Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of…”
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Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1 by Nickerson, Kevin M, Cullen, Jaime L, Kashgarian, Michael, Shlomchik, Mark J

“…TLR9 suppresses TLR7-driven pathogenesis in the MRL.Fas(lpr) murine model of systemic lupus erythematosus, but the mechanisms by which TLR7 promotes and TLR9…”
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B Cell-Extrinsic Myd88 and Fcer1g Negatively Regulate Autoreactive and Normal B Cell Immune Responses by Sweet, Rebecca A, Nickerson, Kevin M, Cullen, Jaime L, Wang, Yujuan, Shlomchik, Mark J

“…MyD88 and FcR common γ-chain (Fcer1g, FcRγ) elicit proinflammatory responses to exogenous Ags. Deletion of these receptors in autoimmune models has generally…”
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Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus by Christensen, Sean R., Shupe, Jonathan, Nickerson, Kevin, Kashgarian, Michael, Flavell, Richard A., Shlomchik, Mark J.

“…Antibodies (Abs) to RNA- and DNA-containing autoantigens are characteristic of systemic lupus erythematosus (SLE). We showed previously that Toll-like receptor…”
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Lupus and proliferative nephritis are PAD4 independent in murine models by Gordon, Rachael A, Herter, Jan M, Rosetti, Florencia, Campbell, Allison M, Nishi, Hiroshi, Kashgarian, Michael, Bastacky, Sheldon I, Marinov, Anthony, Nickerson, Kevin M, Mayadas, Tanya N, Shlomchik, Mark J

“…Though recent reports suggest that neutrophil extracellular traps (NETs) are a source of antigenic nucleic acids in systemic lupus erythematosus (SLE), we…”
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207 ABC and extrafollicular responses: mechanistic insights from murine models of lupus and infection by Elsner, Rebecca, Trivedi, Nikita, Nickerson, Kevin, Shlomchik, Mark J

“…BackgroundAnimal models and more recently studies in humans have implicated the “extrafollicular” (EF) B cell response—rather than the germinal center (GC)…”
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Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice by Nickerson, Kevin M, Wang, Yujuan, Bastacky, Sheldon, Shlomchik, Mark J

“…Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Faslpr murine model of systemic lupus erythematosus, despite the absence…”
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Macroglossia Associated With Clobazam Administration: A Case Report and Literature Review by Zhang, Jeff F, Nickerson, Kevin, Piryani, Ravi, Farooq, Osman, Swayampakula, Anil K

“…Clobazam is a benzodiazepine derivative used as an antiepileptic agent for the treatment of focal and generalized seizures and drug-resistant epilepsy…”
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TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation by Nickerson, Kevin M, Christensen, Sean R, Cullen, Jaime L, Meng, Wenzhao, Luning Prak, Eline T, Shlomchik, Mark J

“…Nucleic acid-reactive B cells frequently arise in the bone marrow but are tolerized by mechanisms including receptor editing, functional anergy, and/or…”
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NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7 by Gordon, Rachael A, Cosgrove, Haylee A, Marinov, Anthony, Gingras, Sebastien, Tilstra, Jeremy S, Campbell, Allison M, Bastacky, Sheldon I, Kashgarian, Michael, Perl, Andras, Nickerson, Kevin M, Shlomchik, Mark J

“…Loss of NADPH oxidase (NOX2) exacerbates systemic lupus erythematosus (SLE) in mice and humans, but the mechanisms underlying this effect remain unclear. To…”
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Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis by Gordon, Rachael A, Giannouli, Christina, Raparia, Chirag, Bastacky, Sheldon I, Marinov, Anthony, Hawse, William, Cattley, Richard, Tilstra, Jeremy S, Campbell, Allison M, Nickerson, Kevin M, Davidson, Anne, Shlomchik, Mark J

“…NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses…”
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402 Genetic dissection of TLR9 reveals complex regulatory and cryptic pro-inflammatory roles by Leibler, Claire, John, Shinu, Thomas, Kayla, Smita, Shuchi, Gordon, Rachael, Tilstra, Jeremy, Gingras, Sebastien, Bastacky, Sheldon, Nickerson, Kevin, Shlomchik, Mark J

“…BackgroundToll like receptors (TLR) 7 and 9, endosomal sensors for ssRNA and dsDNA, are key mediators of lupus autoreactivity. Although considered homologous,…”
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