Search Results - "Nick, Heidi J"

Measurements of spontaneous CFTR-mediated ion transport without acute channel activation in airway epithelial cultures after modulator exposure by Nick, Heidi J., Zeitlin, Pamela L., Yadav, Sangya, Bratcher, Preston E.

“…Quantitation of CFTR function in vitro is commonly performed by acutely stimulating then inhibiting ion transport through CFTR and measuring the resulting…”
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Bacterial Stimulation of Toll-Like Receptor 4 Drives Macrophages To Hemophagocytose by McDonald, Erin M, Pilonieta, M Carolina, Nick, Heidi J, Detweiler, Corrella S

“…During acute infection with bacteria, viruses or parasites, a fraction of macrophages engulf large numbers of red and white blood cells, a process called…”
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MMP-9 cleaves SP-D and abrogates its innate immune functions in vitro by Bratcher, Preston E, Weathington, Nathaniel M, Nick, Heidi J, Jackson, Patricia L, Snelgrove, Robert J, Gaggar, Amit

“…Possession of a properly functioning innate immune system in the lung is vital to prevent infections due to the ongoing exposure of the lung to pathogens…”
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Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women by Shen, Ruizhong, Achenbach, Jenna, Shen, Yue, Palaia, Jana, Rahkola, Jeremy T, Nick, Heidi J, Smythies, Lesley E, McConnell, Michelle, Fowler, Mary G, Smith, Phillip D, Janoff, Edward N

“…Breast milk is a vehicle of infection and source of protection in post-natal mother-to-child HIV-1 transmission (MTCT). Understanding the mechanism by which…”
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Analysis of sodium 2-mercaptoethane sulfonate in rat plasma using high performance liquid chromatography tandem-mass spectrometry by Donkor, Abigail B., White, Carl W., Nick, Heidi J., Logue, Brian A.

“…•MESNA is a drug used to combat the toxic effects of the anti-cancer agents: cyclophosphamide and ifosfamide.•A simple and effective method of analysis for…”
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Mesna Improves Outcomes of Sulfur Mustard Inhalation Toxicity in an Acute Rat Model by Nick, Heidi J, Johnson, Carly A, Stewart, Amber R, Christeson, Sarah E, Bloomquist, Leslie A, Appel, Amanda S, Donkor, Abigail B, Veress, Livia A, Logue, Brian A, Bratcher, Preston E, White, Carl W

“…Inhalation of high levels of sulfur mustard (SM), a potent vesicating and alkylating agent used in chemical warfare, results in acutely lethal pulmonary…”
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Identification and determination of phenyl methyl carbamate released from adducted hemoglobin for methyl isocyanate exposure verification by Donkor, Abigail B., Gyamfi, Obed A., White, Carl W., Nick, Heidi J., Rioux, Jacqueline S., Veress, Livia A., Logue, Brian A.

“…•This paper features a first-time reported sample preparation chemistry for analysis of MIC-tyrosine adducts.•Base-catalyzed hydrolysis of…”
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Acute vaping in a golden Syrian hamster causes inflammatory response transcriptomic changes by Hinds, Daniel M, Nick, Heidi J, Vallin, Tessa M, Bloomquist, Leslie A, Christeson, Sarah, Bratcher, Preston E, Cooper, Emily H, Brinton, John T, Bosco-Lauth, Angela, White, Carl W

“…E-cigarette vaping is a major aspect of nicotine consumption, especially for children and young adults. Although it is branded as a safer alternative to…”
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Alleviation of methyl isocyanate−induced airway obstruction and mortality by tissue plasminogen activator by Nick, Heidi J., Rioux, Jacqueline S., Veress, Livia A., Bratcher, Preston E., Bloomquist, Leslie A., Anantharam, Poojya, Croutch, Claire R., Tuttle, Richard S., Peters, Eric, Sosna, William, White, Carl W.

“…Methyl isocyanate (MIC, “Bhopal agent”) is a highly reactive, toxic industrial chemical. Inhalation of high levels (500–1000 ppm) of MIC vapor is almost…”
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Human intestinal stromal cells promote homeostasis in normal mucosa but inflammation in Crohn’s disease in a retinoic acid–deficient manner by Smythies, Lesley E., Belyaeva, Olga V., Alexander, Katie L., Bimczok, Diane, Nick, Heidi J., Serrano, Carolina A., Huff, Kayci R., Nearing, Marie, Musgrove, Lois, Poovey, Emily H., Garth, Jaleesa, Russ, Kirk, Baig, Kondal R.K.K., Crossman, David K., Peter, Shajan, Cannon, Jamie A., Elson, Charles O., Kedishvili, Natalia Y., Smith, Phillip D.

“…Intestinal stromal cells (SCs), which synthesize the extracellular matrix that gives the mucosa its structure, are newly appreciated to play a role in mucosal…”
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Distinct classes of c-Kit–activating mutations differ in their ability to promote RUNX1-ETO–associated acute myeloid leukemia by Nick, Heidi J., Kim, Hyung-Gyoon, Chang, Chia-Wei, Harris, Kevin W., Reddy, Vishnu, Klug, Christopher A.

“…The t(8;21) RUNX1-ETO translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). In RUNX1-ETO+ patient samples,…”
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Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella enterica Serovar Typhimurium infection in mice by Brown, Diane E, Nick, Heidi J, McCoy, Melissa W, Moreland, Sarah M, Stepanek, Aaron M, Benik, Ross, O'Connell, Karyn E, Pilonieta, Maria C, Nagy, Toni A, Detweiler, Corrella S

“…The Gram-negative intracellular bacterium Salmonella enterica serovar Typhimurium causes persistent systemic inflammatory disease in immunocompetent mice…”
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The Functional Impact of VX-770 on the Cystic Fibrosis Transmembrane Conductance Regulator Is Enduring and Increases the Constitutive Activity of This Channel in Primary Airway Epithelia Generated from Healthy Donors by Nick, Heidi J., Christeson, Sarah E., Bratcher, Preston E.

“…VX-770 is a small-molecule CFTR potentiator that is highly efficacious in individuals with cystic fibrosis caused by mutations in CFTR that result in a defect…”
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The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia by Kim, H-G, LeGrand, J, Swindle, C S, Nick, H J, Oster, R A, Chen, D, Purohit-Ghelani, S, Cotta, C V, Ko, R, Gartland, L, Reddy, V, Hiebert, S W, Friedman, A D, Klug, C A

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Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women: e0145150 by Shen, Ruizhong, Achenbach, Jenna, Shen, Yue, Palaia, Jana, Rahkola, Jeremy T, Nick, Heidi J, Smythies, Lesley E, McConnell, Michelle, Fowler, Mary G, Smith, Phillip D

“…Breast milk is a vehicle of infection and source of protection in post-natal mother-to-child HIV-1 transmission (MTCT). Understanding the mechanism by which…”
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