Search Results - "Nicholson, Wayne"
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Bacillus subtilis ydjL (bdhA) Gene Encodes Acetoin Reductase/2,3-Butanediol Dehydrogenase
Published in Applied and Environmental Microbiology (01-11-2008)“…Bacillus subtilis is capable of producing 2,3-butanediol from acetoin by fermentation, but to date, the gene encoding the enzyme responsible, acetoin…”
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Shelf Life and Simulated Gastrointestinal Tract Survival of Selected Commercial Probiotics During a Simulated Round-Trip Journey to Mars
Published in Frontiers in microbiology (07-10-2021)“…To enhance the gastrointestinal health of astronauts, probiotic microorganisms are being considered for inclusion on long-duration human missions to the Moon…”
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Deployment of convalescent plasma for the prevention and treatment of COVID-19
Published in The Journal of clinical investigation (01-06-2020)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spurred a global health crisis. To date,…”
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The Spectrum of Spontaneous Rifampin Resistance Mutations in the Bacillus subtilis rpoB Gene Depends on the Growth Environment
Published in Applied and environmental microbiology (28-10-2021)“…Results from previous investigations into spontaneous rifampin resistance (Rif ) mutations in the Bacillus subtilis gene suggested that the spectrum of…”
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Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology
Published in American journal of physiology. Heart and circulatory physiology (01-02-2020)“…The introduction of duplex Doppler ultrasound almost half a century ago signified a revolutionary advance in the ability to assess limb blood flow in humans…”
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Cultivation of Staphylococcus epidermidis in the Human Spaceflight Environment Leads to Alterations in the Frequency and Spectrum of Spontaneous Rifampicin-Resistance Mutations in the rpoB Gene
Published in Frontiers in microbiology (28-06-2016)“…Bacteria of the genus Staphylococcus are persistent inhabitants of human spaceflight habitats and represent potential opportunistic pathogens. The effect of…”
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Environmental Dependence of Competitive Fitness in Rifampin-Resistant rpoB Mutants of Bacillus subtilis
Published in Applied and environmental microbiology (08-03-2022)“…RNA polymerase (RNAP) is a highly conserved macromolecular machine that contributes to the flow of genetic information from genotype to phenotype. In Bacillus…”
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A Bumpy Pathway to Stationary-Phase Survival in Bacillus subtilis
Published in mBio (29-10-2019)“…cells can mount a number of responses to nutritional deprivation but ultimately either form dormant spores or enter a metabolically quiescent state. In a…”
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Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification
Published in Applied and Environmental Microbiology (01-01-2014)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cultivation in Space Flight Produces Minimal Alterations in the Susceptibility of Bacillus subtilis Cells to 72 Different Antibiotics and Growth-Inhibiting Compounds
Published in Applied and environmental microbiology (01-11-2017)“…Past results have suggested that bacterial antibiotic susceptibility is altered during space flight. To test this notion, cells were cultivated in matched…”
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Ancient micronauts: interplanetary transport of microbes by cosmic impacts
Published in Trends in microbiology (Regular ed.) (01-06-2009)“…Recent developments in microbiology, geophysics and planetary sciences raise the possibility that the planets in our solar system might not be biologically…”
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Aging Alters the Relative Contributions of the Sympathetic and Parasympathetic Nervous System to Blood Pressure Control in Women
Published in Hypertension (Dallas, Tex. 1979) (01-11-2018)“…Autonomic support of blood pressure increases with age in humans. Large differences exist in the dose of trimethaphan (TMP) required for ganglionic blockade in…”
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Mechanotransduction in Prokaryotes: A Possible Mechanism of Spaceflight Adaptation
Published in Life (Basel, Switzerland) (07-01-2021)“…Our understanding of the mechanisms of microgravity perception and response in prokaryotes (Bacteria and Archaea) lag behind those which have been elucidated…”
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Twenty Species of Hypobarophilic Bacteria Recovered from Diverse Soils Exhibit Growth under Simulated Martian Conditions at 0.7 kPa
Published in Astrobiology (01-12-2016)“…Bacterial growth at low pressure is a new research area with implications for predicting microbial activity in clouds and the bulk atmosphere on Earth and for…”
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Growth of Carnobacterium spp. from permafrost under low pressure, temperature, and anoxic atmosphere has implications for Earth microbes on Mars
Published in Proceedings of the National Academy of Sciences - PNAS (08-01-2013)“…The ability of terrestrial microorganisms to grow in the near-surface environment of Mars is of importance to the search for life and protection of that planet…”
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Pharmacokinetic Pharmacogenetic Prescribing Guidelines for Antidepressants: A Template for Psychiatric Precision Medicine
Published in Mayo Clinic proceedings (01-07-2016)“…Abstract Antidepressants are commonly prescribed medications in the United States, and there is increasing interest in individualizing treatment selection for…”
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Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment
Published in Frontiers in microbiology (14-02-2018)“…The effect of exposure to the human spaceflight environment on growth, mutagenic frequency, and spectrum of mutations to rifampicin resistance (Rif ) was…”
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Meta-analysis of data from spaceflight transcriptome experiments does not support the idea of a common bacterial “spaceflight response”
Published in Scientific reports (26-09-2018)“…Several studies have been undertaken with the goal of understanding how bacterial transcriptomes respond to the human spaceflight environment. However, these…”
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Considerations When Applying Pharmacogenomics to Your Practice
Published in Mayo Clinic proceedings (01-01-2021)“…Many practitioners who have not had pharmacogenomic education are required to apply pharmacogenomics to their practices. Although many aspects of…”
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Education and Knowledge in Pharmacogenomics: Still a Challenge?
Published in Clinical pharmacology and therapeutics (01-05-2018)“…A number of barriers exist for adoption of pharmacogenomics into practice. Physicians, pharmacists, and nurses report limited knowledge about pharmacogenomics…”
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