Search Results - "Nicholson, Susannah E."

The Cutaneous Microbiome and Wounds: New Molecular Targets to Promote Wound Healing by Johnson, Taylor R, Gómez, Belinda I, McIntyre, Matthew K, Dubick, Michael A, Christy, Robert J, Nicholson, Susannah E, Burmeister, David M

“…The ecological community of microorganisms in/on humans, termed the microbiome, is vital for sustaining homeostasis. While culture-independent techniques have…”
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Complement as a vital nexus of the pathobiological connectome for acute respiratory distress syndrome: An emerging therapeutic target by Yang, Zhangsheng, Nicholson, Susannah E, Cancio, Tomas S, Cancio, Leopoldo C, Li, Yansong

“…The hallmark of acute respiratory distress syndrome (ARDS) pathobiology is unchecked inflammation-driven diffuse alveolar damage and alveolar-capillary barrier…”
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A Review of Traumatic Brain Injury and the Gut Microbiome: Insights into Novel Mechanisms of Secondary Brain Injury and Promising Targets for Neuroprotection by Zhu, Caroline S, Grandhi, Ramesh, Patterson, Thomas Tyler, Nicholson, Susannah E

“…The gut microbiome and its role in health and disease have recently been major focus areas of research. In this review, we summarize the different ways in…”
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Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns by Schwacha, Martin G, Rani, Meenakshi, Nicholson, Susannah E, Lewis, Aaron M, Holloway, Travis L, Sordo, Salvador, Cap, Andrew P

“…Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population…”
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Toll-like receptor responses are suppressed in trauma ICU patients by Holloway, Travis L., MD, Nicholson, Susannah E., MD, Rani, Meenakshi, PhD, Cap, Andrew P., MD, PhD, Schwacha, Martin G., PhD

“…Abstract Background Inflammation and activation of the innate immune system is often associated with traumatic injury and may involve alterations in Toll-like…”
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Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation by Rani, Meenakshi, Nicholson, Susannah E, Zhang, Qiong, Schwacha, Martin G

“…Highlights • Burn induced an elevation in circulating DAMPs 3–24 h after injury. • Elevated DAMPs levels were associated with increased IL-6, IL-10 and TNFα. •…”
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Development of a Sleeve Gastrectomy Weight Loss Model in Obese Zucker Rats by Lopez, Peter P., M.D, Nicholson, Susannah E., M.D, Burkhardt, Gabriel E., M.D, Johnson, Robert A., Ph.D, Johnson, Fruzsina K., M.D

“…Background Obesity promotes the development of diabetes and cardiovascular disease. The most effective weight loss treatment is bariatric surgery, but results…”
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Prehospital whole blood reduces early mortality in patients with hemorrhagic shock by Braverman, Maxwell A., Smith, Alison, Pokorny, Douglas, Axtman, Benjamin, Shahan, Charles Patrick, Barry, Lauran, Corral, Hannah, Jonas, Rachelle Babbitt, Shiels, Michael, Schaefer, Randall, Epley, Eric, Winckler, Christopher, Waltman, Elizabeth, Eastridge, Brian J., Nicholson, Susannah E., Stewart, Ronald M., Jenkins, Donald H.

“…Background Low titer O+ whole blood (LTOWB) is being increasingly used for resuscitation of hemorrhagic shock in military and civilian settings. The objective…”
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Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner by Nicholson, Susannah E, Watts, Lora T, Burmeister, David M, Merrill, Daniel, Scroggins, Shannon, Zou, Yi, Lai, Zhao, Grandhi, Ramesh, Lewis, Aaron M, Newton, Larry M, Eastridge, Brian J, Schwacha, Martin G

“…ABSTRACTThe microbiome is defined as the collective genomes of the microbes (composed of bacteria, bacteriophage, fungi, protozoa, and viruses) that colonize…”
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Prehospital low-titer cold-stored whole blood: Philosophy for ubiquitous utilization of O-positive product for emergency use in hemorrhage due to injury by McGinity, Ashley C, Zhu, Caroline S, Greebon, Leslie, Xenakis, Elly, Waltman, Elizabeth, Epley, Eric, Cobb, Danielle, Jonas, Rachelle, Nicholson, Susannah E, Eastridge, Brian J, Stewart, Ronald M, Jenkins, Donald H

“…The mortality from hemorrhage in trauma patients remains high. Early balanced resuscitation improves survival. These truths, balanced with the availability of…”
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Give the trauma patient what they bleed, when and where they need it: establishing a comprehensive regional system of resuscitation based on patient need utilizing cold‐stored, low‐titer O+ whole blood by Zhu, Caroline S., Pokorny, Douglas M., Eastridge, Brian J., Nicholson, Susannah E., Epley, Eric, Forcum, Jason, Long, Tasia, Miramontes, David, Schaefer, Randall, Shiels, Michael, Stewart, Ronald M., Stringfellow, Michael, Summers, Rena, Winckler, Christopher J., Jenkins, Donald H.

“…BACKGROUND Despite countless advancements in trauma care a survivability gap still exists in the prehospital setting. Military studies clearly identify…”
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Spinal cord injury and the human microbiome: beyond the brain-gut axis by Wallace, David J, Sayre, Naomi L, Patterson, T Tyler, Nicholson, Susannah E, Hilton, Donald, Grandhi, Ramesh

“…In addition to standard management for the treatment of the acute phase of spinal cord injury (SCI), implementation of novel neuroprotective interventions…”
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Shock Index and Pulse Pressure as Triggers for Massive Transfusion by Zhu, Caroline S, Cobb, Danielle, Jonas, Rachelle B, Pokorny, Douglas, Rani, Meenakshi, Cotner-Pouncy, Tracy, Oliver, Jenny, Cap, Andrew, Cestero, Ramon, Nicholson, Susannah E, Eastridge, Brian J, Jenkins, Donald H

“…Hemorrhage is the most common cause of preventable death in trauma patients. These mortalities might be prevented with prehospital transfusion. We sought to…”
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Shock index and pulse pressure as triggers for massive transfusion by Zhu, Caroline S, Cobb, Danielle, Jonas, Rachelle B, Pokorny, Douglas, Rani, Meenakshi, Cotner-Pouncy, Tracy, Oliver, Jenny, Cap, Andrew, Cestero, Ramon, Nicholson, Susannah E, Eastridge, Brian J, Jenkins, Donald H

“…Hemorrhage is the most common cause of preventable death in trauma patients. These mortalities might be prevented with prehospital transfusion. We sought to…”
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A survey of low titer O whole blood use within the trauma quality improvement program registry by Schauer, Steven G., April, Michael D., Fisher, Andrew D., Wright, Franklin L., Winkle, Julie M., Wright, Angela R., Rizzo, Julie A., Getz, Todd M., Nicholson, Susannah E., Yazer, Mark H., Braverman, Maxwell A

“…Introduction The use of low titer O whole blood (LTOWB) has expanded although it remains unclear how many civilian trauma centers are using LTOWB. Methods We…”
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The gut microbiome distinguishes mortality in trauma patients upon admission to the emergency department by Burmeister, David M., Johnson, Taylor R., Lai, Zhao, Scroggins, Shannon R., DeRosa, Mark, Jonas, Rachelle B., Zhu, Caroline, Scherer, Elizabeth, Stewart, Ronald M., Schwacha, Martin G., Jenkins, Donald H., Eastridge, Brian J., Nicholson, Susannah E.

“…Traumatic injury can lead to a compromised intestinal epithelial barrier, decreased gut perfusion, and inflammation. While recent studies indicate that the gut…”
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Whole blood resuscitation restores intestinal perfusion and influences gut microbiome diversity by Yracheta, Jaclyn, Muraoka, Wayne, Wu, Xiaowu, Burmeister, David, Darlington, Daniel, Zhao, David, Lai, Zhao, Sayyadioskoie, Shannon, Cap, Andrew P., Bynum, James, Nicholson, Susannah E.

“…Gut dysbiosis, an imbalance in the gut microbiome, occurs after trauma, which may be ameliorated with transfusion. We hypothesized that gut hypoperfusion…”
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Compensatory reserve detects subclinical shock with more expeditious prediction for need of life‐saving interventions compared to systolic blood pressure and blood lactate by Convertino, Victor A., Johnson, Michael C., Alarhayem, Abdul, Nicholson, Susannah E., Chung, Kevin K., DeRosa, Mark, Eastridge, Brian J.

“…Introduction We conducted a prospective observational study on 205 trauma patients at a level I trauma facility to test the hypothesis that a compensatory…”
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Compensatory reserve and pulse character: Enhanced potential to predict urgency for transfusion and other life‐saving interventions after traumatic injury by Ciaraglia, Angelo V., Convertino, Victor A., Johnson, Michael C., DeRosa, Mark, Nicholson, Susannah E., Eastridge, Brian J.

“…Background Field triage of trauma patients requires timely assessment of physiologic status to determine resuscitative needs. Vital signs and rudimentary…”
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Trauma-induced lung injury is associated with infiltration of activated TLR expressing myeloid cells by Rani, Meenakshi, Sayyadioskoie, Shannon R, Galvan, Eva M., Nicholson, Susannah E., Schwacha, Martin G.

“…•Trauma-hemorrhage (TH) markedly increases lung levels of CD11b+ monocytes and GR1+ granulocytes.•The percentage of cells expressing toll-like receptors (TLRs)…”
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