Search Results - "Nicholson, Joshua M"

The mitotic origin of chromosomal instability by Bakhoum, Samuel F., Silkworth, William T., Nardi, Isaac K., Nicholson, Joshua M., Compton, Duane A., Cimini, Daniela

“…Chromosomal instability (CIN) is a common feature of most human neoplasms and was defined, in a seminal study by Vogelstein and colleagues [1], as persistently…”
Get full text

Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells by Baudoin, Nicolaas C, Nicholson, Joshua M, Soto, Kimberly, Martin, Olga, Chen, Jing, Cimini, Daniela

“…Tetraploidy has long been of interest to both cell and cancer biologists, partly because of its documented role in tumorigenesis. A common model proposes that…”
Get full text

Is carcinogenesis a form of speciation? by Duesberg, Peter, Mandrioli, Daniele, McCormack, Amanda, Nicholson, Joshua M.

“…Since cancers have individual clonal karyotypes, are immortal and evolve from normal cells treated by carcinogens only after exceedingly long latencies of many…”
Get full text

Cancer karyotypes: survival of the fittest by Nicholson, Joshua M, Cimini, Daniela

“…Cancer cells are typically characterized by complex karyotypes including both structural and numerical changes, with aneuploidy being a ubiquitous feature. It…”
Get full text

Chromosome mis-segregation and cytokinesis failure in trisomic human cells by Nicholson, Joshua M, Macedo, Joana C, Mattingly, Aaron J, Wangsa, Darawalee, Camps, Jordi, Lima, Vera, Gomes, Ana M, Dória, Sofia, Ried, Thomas, Logarinho, Elsa, Cimini, Daniela

“…Cancer cells display aneuploid karyotypes and typically mis-segregate chromosomes at high rates, a phenotype referred to as chromosomal instability (CIN). To…”
Get full text

Author Correction: Selective advantage of trisomic human cells cultured in non-standard conditions by Rutledge, Samuel D., Douglas, Temple A., Nicholson, Joshua M., Vila-Casadesús, Maria, Kantzler, Courtney L., Wangsa, Darawalee, Barroso-Vilares, Monika, Kale, Shiv D., Logarinho, Elsa, Cimini, Daniela

Get full text

Doubling the deck: Tetraploidy induces chromosome shuffling and cancer by Nicholson, Joshua M., Cimini, Daniela

“…Comment on: Lv L, et al. Cell Cycle 2012; 11:2864-75…”
Get full text

Asymmetric Total Syntheses of Euphol and Tirucallol by Nicholson, Joshua M., Micalizio, Glenn C.

“…Asymmetric de novo syntheses of euphol and tirucallol have been accomplished by way of a concise sequence of chemical steps featuring several modern…”
Get full text

Conform and be funded by Nicholson, Joshua M., Ioannidis, John P. A.

“…Too many US authors of the most innovative and influential papers in the life sciences do not receive NIH funding, contend Joshua M. Nicholson and John P. A…”
Get full text

Research grants: Conform and be funded by Nicholson, Joshua M, Ioannidis, John P A

Get full text

Measuring the quality of scientific references in Wikipedia: an analysis of more than 115M citations to over 800 000 scientific articles by Nicholson, Joshua M., Uppala, Ashish, Sieber, Matthias, Grabitz, Peter, Mordaunt, Milo, Rife, Sean C.

“…Wikipedia is a widely used online reference work. To determine the quality of the citations appearing in Wikipedia articles, we analyzed 1 923 575 Wikipedia…”
Get full text

Link between Aneuploidy and Chromosome Instability by Nicholson, Joshua M, Cimini, Daniela

“…Aneuploidy is widely acknowledged as a leading cause of miscarriage and birth defects in humans, and is generally known to be deleterious to the survival of…”
Get full text

Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF‑α and IL‑6 Release by Nicholson, Joshua M., Yang, Dexi, Koelblen, Thomas, Hu, Eric L., Coss, Christopher C., Burris, Thomas P., Hu, Xiao, Micalizio, Glenn C.

“…Natural products are widely recognized as valuable starting points for the development of therapeutics, with synthetic tetracyclic triterpenoids (e.g.,…”
Get full text

General Enantioselective and Stereochemically Divergent Four-Stage Approach to Fused Tetracyclic Terpenoid Systems by Nicholson, Joshua M, Millham, Adam B, Bucknam, Andrea R, Markham, Lauren E, Sailors, Xenia Ivanna, Micalizio, Glenn C

“…Tetracyclic terpenoid-derived natural products are a broad class of medically relevant agents that include well-known steroid hormones and related structures,…”
Get full text

Selective advantage of trisomic human cells cultured in non-standard conditions by Rutledge, Samuel D., Douglas, Temple A., Nicholson, Joshua M., Vila-Casadesús, Maria, Kantzler, Courtney L., Wangsa, Darawalee, Barroso-Vilares, Monika, Kale, Shiv D., Logarinho, Elsa, Cimini, Daniela

“…An abnormal chromosome number, a condition known as aneuploidy, is a ubiquitous feature of cancer cells. A number of studies have shown that aneuploidy impairs…”
Get full text

scite: The next generation of citations by Rife, Sean C., Rosati, Domenic, Nicholson, Joshua M.

“…Key points While the importance of citation context has long been recognized, simple citation counts remain as a crude measure of importance. Providing…”
Get full text

Collegiality and careerism trump critical questions and bold new ideas: A student's perspective and solution by Nicholson, Joshua M.

“…Funding agencies (and journals) seem to be discriminating against ideas that are contrary to the mainstream, leading to leading to the preferential funding of…”
Get full text

Collegiality and careerism trump critical questions and bold new ideas: a student's perspective and solution. The structure of scientific funding limits bold new ideas by Nicholson, Joshua M

“…Funding agencies (and journals) seem to be discriminating against ideas that are contrary to the mainstream, leading to leading to the preferential funding of…”
Get full text

Copper-catalyzed three-component synthesis of pyrrole-substituted 1,2-dihydroisoquinolines by Floyd, Matthew D., Ryan, Lianne Y., Hendsey, Jessica L., Nicholson, Joshua M., Palaia, Andrew T., Isaacs, André K.

“…A general approach to the synthesis of 1,3-disubstituted-1,2-dihydroisoquinolines was achieved with pyrrole and various electron withdrawing groups as…”
Get full text

How Mitotic Errors Contribute to Karyotypic Diversity in Cancer by Nicholson, Joshua M., Cimini, Daniela

“…Aneuploidy is a common feature of cancer cells, and is believed to play a critical role in tumorigenesis and cancer progression. Most cancer cells also exhibit…”
Get full text