Search Results - "Nicholson, I. C."

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia by IMAI, C, MIHARA, K, ANDREANSKY, M, NICHOLSON, I. C, PUI, C-H, GEIGER, T. L, CAMPANA, D

“…To develop a therapy for drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we transduced T lymphocytes with anti-CD19 chimeric receptors, consisting…”
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In silico evaluation of two mass spectrometry-based approaches for the identification of novel human leukocyte cell-surface proteins by Nicholson, I. C., Ayhan, M., Hoogenraad, N. J., Zola, H.

“…The identification and quantitation of cell‐surface proteins expressed by leukocytes currently use the wide availability of monoclonal antibodies (mAb) in…”
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Somatic hypermutation of immunoglobulin genes in human neonates by RIDINGS, J., NICHOLSON, I. C., GOLDSWORTHY, W., HASLAM, R., ROBERTON, D. M., ZOLA, H.

“…The antibody response in the young infant is limited in several ways; in particular, responses generally are of low affinity and restricted to IgM. This raises…”
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CD62L (L-selectin) by Nicholson, I C

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Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1 by Adamson, P.J., Millard, D.J., Hohmann, A.W., Mavrangelos, C., Macardle, P.J., Pilkington, G., Mulhern, T.D., Tedder, T.F., Zola, H., Nicholson, I.C.

“…We have prepared single-chain immunoglobulin Fv fragments from the CD20-specific hybridoma HB13d. One scFv clone demonstrated strong binding to a CD20-derived…”
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B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Eμ) by PALOMO, C, XIANGANG ZOU, NICHOLSON, I. C, BÜTZLER, C, BRÜGGEMANN, M

“…We have used YAC (yeast artificial chromosome) technology to create large translocation regions where the c-myc proto-oncogene is coupled to the core region of…”
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Toll-like receptors by Dasari, P, Nicholson, I C, Zola, H

“…Toll-like receptors are a family of transmembrane receptors responsible for recognition and initiation of a response to invading microbes by the immune system…”
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Histamine receptors on T lymphocytes by Perry, N L, Zola, H, Nicholson, I C

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CD20 by Macardle, P J, Nicholson, I C

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Memory B lymphocytes in human tonsil do not express surface IgD by Nicholson, IC, Brisco, MJ, Zola, H

“…To clarify the phenotype of memory B lymphocytes, we have determined the frequency of somatic hypermutations in purified tonsil B cell populations. Our…”
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Expression of toll-like receptors on B lymphocytes by Dasari, Pallave, Nicholson, Ian C., Hodge, Greg, Dandie, Geoffrey W., Zola, Heddy

“…Toll-like receptors (TLRs) are a family of trans-membrane receptors that play an important role in the innate immune system. Most studies examining the…”
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CD32 (Fc gammaRII) by Zola, H, Jessup, C, Nicholson, I C, Macardle, P J

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Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma by Nicholson, Ian C., Lenton, Kelly A., Little, Debbie J., Decorso, Tina, Lee, Fook Thean, Scott, Andrew M., Zola, Heddy, Hohmann, Arthur W.

“…The B cell specific antigen CD19 is a target for the immunotherapy of B lineage leukaemias and lymphomas. We have engineered a single chain Fv (scFv) fragment…”
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Characterisation of the protein composition of peripheral blood mononuclear cell microsomes by SDS-PAGE and mass spectrometry by Nicholson, Ian C., Mavrangelos, Chris, Fung, Kim, Ayhan, Mustafa, Levichkin, Ilya, Johnston, Amelia, Zola, Heddy, Hoogenraad, Nicholas J.

“…Approximately 340 leucocyte plasma membrane proteins have been characterised by the eight Human Leucocyte Differentiation Antigen workshops held between 1982…”
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Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes by Nicholson, I C, Zou, X, Popov, A V, Cook, G P, Corps, E M, Humphries, S, Ayling, C, Goyenechea, B, Xian, J, Taussig, M J, Neuberger, M S, Brüggemann, M

“…We have produced mice that carry the human Ig heavy (IgH) and both kappa and lambda light chain transloci in a background in which the endogenous IgH and kappa…”
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A human immunoglobulin lambda locus is similarly well expressed in mice and humans by Popov, A V, Zou, X, Xian, J, Nicholson, I C, Brüggemann, M

“…Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) lambda light (L) chain locus in germline configuration were created. The introduced…”
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Increased Yield and Activity of Soluble Single-Chain Antibody Fragments by Combining High-Level Expression and the Skp Periplasmic Chaperonin by Mavrangelos, Chris, Thiel, Michael, Adamson, Penelope J., Millard, Debbrah J., Nobbs, Silvia, Zola, Heddy, Nicholson, Ian C.

“…The success of recombinant antibody fragments as diagnostic reagents and therapeutic agents depends on the availability of sufficient functional material. We…”
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Novel control motif cluster in the IgH delta-gamma 3 interval exhibits B cell-specific enhancer function in early development by Mundt, C A, Nicholson, I C, Zou, X, Popov, A V, Ayling, C, Brüggemann, M

“…The majority of the human Ig heavy chain (IgH) constant (C) region locus has been cloned and mapped. An exception is the region between C delta and C gamma 3,…”
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Detection of low-abundance membrane markers by immunofluorescence—a comparison of alternative high-sensitivity methods and reagents by Mavrangelos, Christos, Swart, Bernadette, Nobbs, Silvia, Nicholson, Ian C, Macardle, Peter J, Zola, Heddy

“…The analysis of membrane molecules using antibodies detected by immunofluorescence staining and flow cytometry is used widely in research and diagnostic…”
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Tolerization as a tool for generating novel monoclonal antibodies by Holbrook, Felicity L, Nicholson, Ian C, Zola, Heddy

“…Standard hybridoma production involves the fusion of spleen cells from an immunized mouse with a non‐secretory murine myeloma cell line. While this technology…”
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