Search Results - "Nicholson, B F"

Connexin hemichannel blockade improves outcomes in a model of fetal ischemia by Davidson, Joanne O., Green, Colin R., B. Nicholson, Louise F., O'Carroll, Simon J., Fraser, Mhoyra, Bennet, Laura, Jan Gunn, Alistair

“…Objective: Connexin hemichannels can open during ischemia, resulting in loss of membrane potential, calcium influx, and release of glutamate. In this study, we…”
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Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats by Mao, Yilin, Nguyen, Tara, Tonkin, Ryan S., Lees, Justin G., Warren, Caitlyn, O’Carroll, Simon J., Nicholson, Louise F. B., Green, Colin R., Moalem-Taylor, Gila, Gorrie, Catherine A.

“…Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to reduce secondary tissue damage and improve functional recovery after…”
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Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier by Griffin, Jarred M, Kho, Dan, Graham, E Scott, Nicholson, Louise F B, O'Carroll, Simon J

“…Astrocytes and cerebral endothelial cells are important components of the blood-brain barrier (BBB). Disruption to this barrier through inflammation is a major…”
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Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion by Yoon, Jinny J, Green, Colin R, O’Carroll, Simon J, Nicholson, Louise F.B

“…Summary Epileptic seizures typically result in delayed neuronal loss secondary to the initial damage and an up-regulation in connexin43 (Cx43). This study…”
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A key role for connexin hemichannels in spreading ischemic brain injury by Davidson, Joanne O, Green, Colin R, Bennet, Laura, Nicholson, Louise F B, Danesh-Meyer, Helen, O'Carroll, Simon J, Gunn, Alistair J

“…Brain damage resulting from cerebral ischemia remains a significant problem at all stages of life. In adults, ischemic stroke is the third leading cause of…”
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Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia by Danesh-Meyer, Helen V., Kerr, Nathan M., Zhang, Jie, Eady, Elizabeth K., O'Carroll, Simon J., Nicholson, Louise F.B., Johnson, Cameron S., Green, Colin R.

“…Connexin43 gap junction protein is expressed in astrocytes and the vascular endothelium in the central nervous system. It is upregulated following central…”
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Vascular Degeneration in Parkinson's Disease by Guan, Jian, Pavlovic, Darja, Dalkie, Nicholas, Waldvogel, Henry J., O'Carroll, Simon J., Green, Colin R., Nicholson, Louise F.B.

“…Vascular degeneration plays a significant role in contributing to neurodegenerative conditions such as Alzheimer's disease. Our understanding of the vascular…”
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Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep by Davidson, J.O., Green, C.R., Nicholson, L.F.B., Bennet, L., Gunn, A.J.

“…There is increasing evidence that connexin hemichannels, the half gap junctions that sit unopposed in the cell membrane, can open during ischemia and that…”
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Deleterious effects of high dose connexin 43 mimetic peptide infusion after cerebral ischaemia in near-term fetal sheep by Davidson, Joanne O, Green, Colin R, Nicholson, Louise F B, Bennet, Laura, Gunn, Alistair J

“…Hypoxic-ischaemic brain injury at birth is associated with 1-3/1000 cases of moderate to severe encephalopathy. Previously, we have shown that connexin 43…”
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Systemic Administration of Connexin43 Mimetic Peptide Improves Functional Recovery after Traumatic Spinal Cord Injury in Adult Rats by Mao, Yilin, Tonkin, Ryan S, Nguyen, Tara, O'Carroll, Simon J, Nicholson, Louise F B, Green, Colin R, Moalem-Taylor, Gila, Gorrie, Catherine A

“…Blocking of Connexin43 hemichannels, the main gap junction protein located on astrocytes in the central nervous system, has been shown to reduce neural injury…”
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AGEs–RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells by Shaikh, Shamim B., Uy, Benedict, Perera, Amali, Nicholson, Louise F.B.

“…► Connexin43 is a downstream effector of AGEs–RAGE pathway in microglial CHME-5 cells. ► A connexin43 positive 51kDa band was induced specifically by TNF-α in…”
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Percutaneous endoscopic gastrostomy: A review of indications, complications and outcome by Nicholson, Fiona B, Korman, Melvyn G, Richardson, Maureen A

“…Percutaneous endoscopic gastrostomy (PEG) was first described in 1980 as an effective method of feeding via the stomach in situations where oral intake is not…”
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Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease by Dowie, M.J, Bradshaw, H.B, Howard, M.L, Nicholson, L.F.B, Faull, R.L.M, Hannan, A.J, Glass, M

“…Abstract Huntington's disease (HD) is an inherited neurodegenerative disease characterised by cell dysfunction and death in the basal ganglia and cortex…”
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Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice by Dowie, M.J, Howard, M.L, Nicholson, L.F.B, Faull, R.L.M, Hannan, A.J, Glass, M

“…Abstract Early loss of CB1 receptors is a hallmark of human Huntington's disease. Data from rodent studies suggest that preservation and activation of CB1…”
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Review article: population screening for colorectal cancer by NICHOLSON, F. B., BARRO, J. L., ATKIN, W., LILFORD, R., PATNICK, J., WILLIAMS, C. B., PIGNONE, M., STEELE, R., KAMM, M. A.

“…Summary Colorectal cancer is a common cancer and common cause of death. The mortality rate from colorectal cancer can be reduced by identification and removal…”
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Recent developments in CT colonography by Nicholson, F.B., Taylor, S., Halligan, S., Kamm, M.A.

“…CT colonography allows reliable, non-invasive, rapid, high resolution imaging of the whole large bowel. Recent advances in technology such as computer-aided…”
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Pharmacological modulation of gut mucosal and large vessel blood flow by KAMM, M. A., JORDAN, C. C., LEAKER, B. R., NICHOLSON, F. B., MURRAY, C. D. R., TAYLOR, S., MARSHALL, M., GIBBS, A., CARTER, E. G., EMMANUEL, A. V.

“…Summary Background Constipation, diminished gut blood flow, ischaemic colitis and drug therapy may be associated. Aim To study the effect of constipating…”
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Assessing RNA quality in postmortem human brain tissue by Chevyreva, Ia, Faull, Richard L.M., Green, Colin R., Nicholson, Louise F.B.

“…The development of microarrays for the screening of gene expression has highlighted the importance of obtaining high quality RNA. We have investigated whether…”
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Connexins and Pannexins in cerebral ischemia by Kim, Yeri, Davidson, Joanne O., Green, Colin R., Nicholson, Louise F.B., O'Carroll, Simon J., Zhang, Jie

“…A common cause of mortality and long-term adult disability, cerebral ischemia or brain ischemia imposes a significant health and financial burden on…”
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A model for ex vivo spinal cord segment culture—A tool for analysis of injury repair strategies by Zhang, Jie, O’Carroll, Simon J., Wu, Ann, Nicholson, Louise F.B., Green, Colin R.

“…Most spinal cord injury research is undertaken using in vivo animal models but the extensive care associated with spinalised animals, inherent variability…”
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