Search Results - "Nicholson, Anna M."

Intestinal label-retaining cells are secretory precursors expressing Lgr5 by Buczacki, Simon J. A., Zecchini, Heather Ireland, Nicholson, Anna M., Russell, Roslin, Vermeulen, Louis, Kemp, Richard, Winton, Douglas J.

“…The rapid cell turnover of the intestinal epithelium is achieved from small numbers of stem cells located in the base of glandular crypts. These stem cells…”
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Continuous Clonal Labeling Reveals Small Numbers of Functional Stem Cells in Intestinal Crypts and Adenomas by Kozar, Sarah, Morrissey, Edward, Nicholson, Anna M., van der Heijden, Maartje, Zecchini, Heather I., Kemp, Richard, Tavaré, Simon, Vermeulen, Louis, Winton, Douglas J.

“…Lineage-tracing approaches, widely used to characterize stem cell populations, rely on the specificity and stability of individual markers for accurate…”
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Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation by Vermeiden, Louis, Morrissey, Edward, van der Heijden, Maartje, Nicholson, Anna M., Sottoriva, Andrea, Buczacki, Simon, Kemp, Richard, Tavaré, Simon, Winton, Douglas J.

“…Cancer is a disease in which cells accumulate genetic aberrations that are believed to confer a clonal advantage over cells in the surrounding tissue. However,…”
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Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium by Nicholson, Anna M., Olpe, Cora, Hoyle, Alice, Thorsen, Ann-Sofie, Rus, Teja, Colombé, Mathilde, Brunton-Sim, Roxanne, Kemp, Richard, Marks, Kate, Quirke, Phil, Malhotra, Shalini, ten Hoopen, Rogier, Ibrahim, Ashraf, Lindskog, Cecilia, Myers, Meagan B., Parsons, Barbara, Tavaré, Simon, Wilkinson, Mark, Morrissey, Edward, Winton, Douglas J.

“…We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference…”
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Bcl-2 is a critical mediator of intestinal transformation by van der Heijden, Maartje, Zimberlin, Cheryl D., Nicholson, Anna M., Colak, Selcuk, Kemp, Richard, Meijer, Sybren L., Medema, Jan Paul, Greten, Florian R., Jansen, Marnix, Winton, Douglas J., Vermeulen, Louis

“…Intestinal tumour formation is generally thought to occur following mutational events in the stem cell pool. However, active NF-κB signalling additionally…”
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Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor by Nicholson, Anna M, Graham, Trevor A, Simpson, Ashley, Humphries, Adam, Burch, Nicola, Rodriguez-Justo, Manuel, Novelli, Marco, Harrison, Rebecca, Wright, Nicholas A, McDonald, Stuart A C, Jankowski, Janusz A

“…Little is known about the stem cell organisation of the normal oesophagus or Barrett's metaplastic oesophagus. Using non-pathogenic mitochondrial DNA mutations…”
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Identification of Lineage-Uncommitted, Long-Lived, Label-Retaining Cells in Healthy Human Esophagus and Stomach, and in Metaplastic Esophagus by Pan, Qiuwei, Nicholson, Anna M, Barr, Hugh, Harrison, Lea–Anne, Wilson, George D, Burkert, Julia, Jeffery, Rosemary, Alison, Malcolm R, Looijenga, Leendert, Lin, Wey–Ran, McDonald, Stuart A.C, Wright, Nicholas A, Harrison, Rebecca, Peppelenbosch, Maikel P, Jankowski, Janusz A

“…Background & Aims The existence of slowly cycling, adult stem cells has been challenged by the identification of actively cycling cells. We investigated the…”
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Field Cancerization in the Intestinal Epithelium of Patients With Crohn's Ileocolitis by Galandiuk, Susan, Rodriguez–Justo, Manuel, Jeffery, Rosemary, Nicholson, Anna M, Cheng, Yong, Oukrif, Dahmane, Elia, George, Leedham, Simon J, McDonald, Stuart A.C, Wright, Nicholas A, Graham, Trevor A

“…Background & Aims Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with…”
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The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands by Lavery, Danielle L, Nicholson, Anna M, Poulsom, Richard, Jeffery, Rosemary, Hussain, Alia, Gay, Laura J, Jankowski, Janusz A, Zeki, Sebastian S, Barr, Hugh, Harrison, Rebecca, Going, James, Kadirkamanathan, Sritharan, Davis, Peter, Underwood, Timothy, Novelli, Marco R, Rodriguez-Justo, Manuel, Shepherd, Neil, Jansen, Marnix, Wright, Nicholas A, McDonald, Stuart A C

“…Barrett's oesophagus shows appearances described as 'intestinal metaplasia', in structures called 'crypts' but do not typically display crypt architecture…”
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Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo by MILICIC, Anita, HARRISON, Lea-Anne, EAST, Philip, OBSZYNSKA, Jolanta, SANDERS, Scott, PIAZUELO, Elena, SHAW, Jacqui, HARRISON, Rebecca, TOMLINSON, Ian P, MCDONALD, Stuart A. C, WRIGHT, Nicholas A, JANKOWSKI, Janusz A. Z, GOODLAD, Robert A, HARDY, Robert G, NICHOLSON, Anna M, PRESZ, Michal, SIEBER, Oliver, SANTANDER, Sonia, PRINGLE, James H, MANDIR, Nikki

“…P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be…”
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279 The Stem Cell Organization, and the Proliferative and Gene Expression Profile of Barrett's Epithelium, Indicates Its Origin From Gastric Glands by Lavery, Danielle L, Nicholson, Anna M, Barr, Hugh, Gay, Laura J, Jeffery, Rosemary, Poulsom, Richard, Harrison, Rebecca F, Jankowski, Janusz A, Jansen, Marnix, Novelli, Marco, McDonald, Stuart A, Rodriguez-Justo, Manuel, Shepherd, Neil A, Wright, Nicholas A

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Altered Stem Cell Dynamics in Human Colon Adenoma Crypts Allow Rapid Expansion and Fixation of Mutations During Clonal Expansion by Humphries, Adam, Graham, Trevor A, Nicholson, Anna M, McDonald, Stuart A, Wright, Nicholas A

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947 Analysis of the Clonality of Barrett's Esophagus Glands Reveals They are Clonal Units and Establishes a Common Stem Cell for Glandular and Squamous Epithelium by Nicholson, Anna M, Graham, Trevor A, Simpson, Ashley I, Humphries, Adam, Wright, Nicholas A, McDonald, Stuart A, Jankowski, Janusz A

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M1970 Differential Effects of TNF-α On Oesophageal Cell Lines Along the Metaplasia-Dysplasia-Adenocarcinoma Sequence by Nicholson, Anna M, Arscott, Ramon D, Milicic, Anita, Jankowski, Janusz A

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T1738 Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA in Situ Hybridisation by McDonald, Stuart A, Jeffery, Rosemary, Humphries, Adam, Leedham, Simon, Graham, Trevor A, Lewis, Annabelle, Segditsas, Stefania, Rodriguez-Justo, Manuel, Nicholson, Anna M, Novelli, Marco, Bamba, Shigeki, Jankowski, Janusz A, Wright, Nicholas A, Poulsom, Richard

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M1620 The Saint Trial (Stem Cell Analysis and Identification By Iudr Labelling of Neoplastic Tissue); Identification of Barrett's Stem Cells by Nicholson, Anna M, Harrison, Lea-Anne, Barr, Hugh, Burkert, Julia, Wilson, George, McDonald, Stuart A, Wright, Nicholas A, Harrison, Rebecca F, Jankowski, Janusz A

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M1969 Expression of Hypoxia Inducible Factor 1α (HIF-1α) in the Progression to Oesophageal Adenocarcinoma: A Key Target for Therapy by Teratani, Naoki, Nicholson, Anna M, Atherfold, Paul A, Milicic, Anita, Jankowski, Janusz A

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Ectopic expression of P-Cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in mice by Milicic, Anita, Harrison, Lea-Anne, Goodlad, Robert A., Hardy, Robert G., Nicholson, Anna M., Presz, Michal, Sieber, Oliver, Santander, Sonia, Pringle, James H., Mandir, Nikki, East, Philip, Obszynska, Jolanta, Sanders, Scott, Piazuelo, Elena, Shaw, Jacqui, Harrison, Rebecca, Tomlinson, Ian P., McDonald, Stuart A. C., Wright, Nicholas A., Jankowski, Janusz A. Z.

“…P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be…”
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