Search Results - "Nichols, Ralph"

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells by He, Feng, Nichols, Ralph M, Kailasam, Lavanya, Wensel, Theodore G, Agosto, Melina A

“…Phosphatidylinositol-3-phosphate (PI(3)P), and Vps34, the type III phosphatidylinositol 3-kinase primarily responsible for its production, are important for…”
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Iodine speciation in a silver-amended cementitious system by Kaplan, Daniel I., Price, Kimberly A., Xu, Chen, Li, Dien, Lin, Peng, Xing, Wei, Nichols, Ralph, Schwehr, Kathleen, Seaman, John C., Ohnuki, Toshihiko, Chen, Ning, Santschi, Peter H.

“…Silver-impregnated zeolite (AgIZ) has been used for removing radioiodine from contaminated groundwater and nuclear waste streams and the worldwide inventory of…”
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AUF1-RGG peptides up-regulate the VEGF antagonist, soluble VEGF receptor-1 (sFlt-1) by Fellows, Abigail, Mierke, Dale F., Nichols, Ralph C.

“…•The AUF1-RGG peptides are novel reagents that are modeled on the RGG regulatory region of AUF1.•AUF1-RGG peptides decrease expression of VEGF and stimulate…”
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WITHDRAWN: AUF1-RGG peptides up-regulate the VEGF antagonist, soluble VEGF receptor-1 (sFlt-1) by Fellows, Abigail, Mierke, Dale, Nichols, Ralph C

“…This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier…”
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Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant by Price, Brandee A, Sandoval, Ivette M, Chan, Fung, Nichols, Ralph, Roman-Sanchez, Ramon, Wensel, Theodore G, Wilson, John H

“…Two outstanding unknowns in the biology of photoreceptors are the molecular determinants of cell size, which is remarkably uniform among mammalian species, and…”
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AUF1/hnRNP D represses expression of VEGF in macrophages by Fellows, Abigail, Griffin, Mary E, Petrella, Brenda L, Zhong, Lihui, Parvin-Nejad, Fatemeh P, Fava, Roy, Morganelli, Peter, Robey, R Brooks, Nichols, Ralph C

“…Vascular endothelial growth factor (VEGF) is a regulator of vascularization in development and is a key growth factor in tissue repair. In disease, VEGF…”
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Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3′ UTR-dependent gene expression by Fellows, Abigail, Deng, Bin, Mierke, Dale F., Robey, R. Brooks, Nichols, Ralph C.

“…Messenger RNA binding proteins control post-transcriptional gene expression of targeted mRNAs. The RGG (arginine-glycine-glycine) domain of the AUF1/hnRNP-D…”
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REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking by Agrawal, Smriti A., Burgoyne, Thomas, Eblimit, Aiden, Bellingham, James, Parfitt, David A., Lane, Amelia, Nichols, Ralph, Asomugha, Chinwe, Hayes, Matthew J., Munro, Peter M., Xu, Mingchu, Wang, Keqing, Futter, Clare E., Li, Yumei, Chen, Rui, Cheetham, Michael E.

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Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes by Noreault-Conti, Trisha L., Fellows, Abigail, Jacobs, Judith M., Trask, Heidi W., Strom, Stephen C., Evans, Ronald M., Wrighton, Steven A., Sinclair, Peter R., Sinclair, Jacqueline F., Nichols, Ralph C.

“…Arsenite is critical pharmacologically as a treatment for advanced stage blood cancer. However, environmental exposure to arsenic results in multiple diseases…”
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A Flexible Approach to Studying Post-Transcriptional Gene Regulation in Stably Transfected Mammalian Cells by Nichols, Ralph C., Botson, John, Wang, Xiao Wei, Hamilton, B. JoNell, Collins, Jane E., Uribe, Victoria, Brooks, Seth A., Zan, Moe, Rigby, William F. C.

“…The study of post-transcriptional regulation is constrained by the technical limitations associated with both transient and stable transfection of chimeric…”
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Post-transcriptional regulation of glucose transporter-1 by an AU-rich element in the 3 ′UTR and by hnRNP A2 by Griffin, Mary E, Hamilton, B.JoNell, Roy, Kristen M, Du, Min, Willson, Alicia M, Keenan, Benjamin J, Wang, Xiao Wei, Nichols, Ralph C

“…Glucose transporter-1 (GLUT1) mediates uptake of glucose and is up-regulated in some cancers. The amount of this membrane protein is regulated by a…”
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VEGF gene expression is regulated post‐transcriptionally in macrophages by Du, Min, Roy, Kristen M., Zhong, Lihui, Shen, Zheng, Meyers, Hannah E., Nichols, Ralph C.

“…The macrophage is critical to the innate immune response and contributes to human diseases, including inflammatory arthritis and plaque formation in…”
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Arsenite decreases CYP3A4 and RXRα in primary human hepatocytes by NOREAULT, Trisha L, KOSTRUBSKY, Vsevolod E, SINCLAIR, Jacqueline F, WOOD, Sheryl G, NICHOLS, Ralph C, STROM, Stephen C, TRASK, Heidi W, WRIGHTON, Steven A, EVANS, Ronald M, JACOBS, Judith M, SINCLAIR, Peter R

“…Arsenic is a naturally occurring, worldwide contaminant implicated in numerous pathological conditions in humans, including cancer and several forms of liver…”
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The RGG Domain in hnRNP A2 Affects Subcellular Localization by Nichols, Ralph C., Wang, Xiao Wei, Tang, Jie, Hamilton, B.JoNell, High, Frances A., Herschman, Harvey R., Rigby, William F.C.

“…The heterogeneous nuclear ribonucleoproteins (hnRNP) associate with pre-mRNA in the nucleus and play an important role in RNA processing and splice site…”
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Soil vapor extraction system design: A case study comparing vacuum and pore-gas velocity cutoff criteria by Dixon, Kenneth L., Nichols, Ralph L.

“…Soil vapor extraction (SVE) systems are typically designed based on the results of a vadose‐zone pumping test (transient or steady‐state) using a pressure…”
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BIOSTRATIGRAPHY AND MAGNETOSTRATIGRAPHY OF THE MID-MIOCENE RAILROAD CANYON SEQUENCE, MONTANA AND IDAHO, AND AGE OF THE MID-TERTIARY UNCONFORMITY WEST OF THE CONTINENTAL DIVIDE by BARNOSKY, ANTHONY D, BIBI, FAYSAL, HOPKINS, SAMANTHA S. B, NICHOLS, RALPH

“…The Barstovian of the northern Rocky Mountains, U.S.A., is known mainly from deposits east of the continental divide; this article provides new information…”
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Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms by Noreault, Trisha L., Jacobs, Judith M., Nichols, Ralph C., Trask, Heidi W., Wrighton, Steven A., Sinclair, Peter R., Evans, Ronald M., Sinclair, Jacqueline F.

“…Arsenic is a naturally occurring, worldwide contaminant implicated in numerous pathological conditions in humans, including cancer and several forms of liver…”
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Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: Comparison with arsenite by Noreault-Conti, Trisha L., Jacobs, Judith M., Trask, Heidi W., Wrighton, Steven A., Sinclair, Jacqueline F., Nichols, Ralph C.

“…Previous work in our laboratory has shown that acute exposure of primary rat hepatocyte cultures to non-toxic concentrations of arsenite causes major decreases…”
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Large seasonal fluctuations of groundwater radioiodine speciation and concentrations in a riparian wetland in South Carolina by Kaplan, Daniel I., Nichols, Ralph, Xu, Chen, Lin, Peng, Yeager, Chris, Santschi, Peter H.

“…Recent studies evaluating multiple years of groundwater radioiodine (129I) concentration in a riparian wetland located in South Carolina, USA identified strong…”
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Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes by Noreault, Trisha L., Jacobs, Judith M., Nichols, Ralph C., Trask, Heidi W., Wrighton, Steven A., Sinclair, Peter R., Sinclair, Jacqueline F.

“…In primary cultures of rat hepatocytes, exposure to arsenite causes a major decrease in dexamethasone (DEX)-mediated induction of CYP3A23 hemoprotein, with a…”
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