Search Results - "Nichols, Connie"

A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans by Probst, Corinna, Hallas-Møller, Magnus, Ipsen, Johan Ø, Brooks, Jacob T, Andersen, Karsten, Haon, Mireille, Berrin, Jean-Guy, Martens, Helle J, Nichols, Connie B, Johansen, Katja S, Alspaugh, J Andrew

“…Fungi often adapt to environmental stress by altering their size, shape, or rate of cell division. These morphological changes require reorganization of the…”
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Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition by Esher, Shannon K, Ost, Kyla S, Kohlbrenner, Maria A, Pianalto, Kaila M, Telzrow, Calla L, Campuzano, Althea, Nichols, Connie B, Munro, Carol, Wormley, Jr, Floyd L, Alspaugh, J Andrew

“…The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both in size and composition, upon entering the host. This cell wall…”
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Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule by O'Meara, Teresa R, Norton, Diana, Price, Michael S, Hay, Christie, Clements, Meredith F, Nichols, Connie B, Alspaugh, J Andrew

“…Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have…”
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CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair by O'Meara, Matthew J, Rapala, Jackson R, Nichols, Connie B, Alexandre, A Christina, Billmyre, R Blake, Steenwyk, Jacob L, Alspaugh, J Andrew, O'Meara, Teresa R

“…Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular…”
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Visualization and Documentation of Capsule and Melanin Production in Cryptococcus neoformans by Nichols, Connie B

“…Cryptococcus neoformans is an opportunistic fungal pathogen primarily targeting immunosuppressed populations in both resource-rich and resource-limited…”
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Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase by Wang, You, Xu, Feng, Nichols, Connie B., Shi, Yuqian, Hellinga, Homme W., Alspaugh, J. Andrew, Distefano, Mark D., Beese, Lorena S.

“…Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and emerging resistances. Next-generation antifungals therefore are…”
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A fungal ubiquitin ligase and arrestin binding partner contribute to pathogenesis and survival during cellular stress by du Plooy, Lukas M, Telzrow, Calla L, Nichols, Connie B, Probst, Corinna, Castro-Lopez, Natalia, Wormley, Jr, Floyd L, Alspaugh, J Andrew

“…Cellular responses to external stress allow microorganisms to adapt to a vast array of environmental conditions, including infection sites. The molecular…”
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Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans by Ballou, Elizabeth Ripley, Kozubowski, Lukasz, Nichols, Connie B, Alspaugh, J Andrew

“…Proliferation and morphogenesis in eukaryotic cells depend on the concerted activity of Rho-type GTPases, including Ras, Cdc42, and Rac. The sexually dimorphic…”
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Human IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans by Trevijano-Contador, Nuria, Pianalto, Kaila M, Nichols, Connie B, Zaragoza, Oscar, Alspaugh, J Andrew, Pirofski, Liise-Anne

“…Human studies have shown associations between cryptococcal meningitis and reduced IgM memory B cell levels, and studies in IgM- and/or B cell-deficient mice…”
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HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence by Brandão, Fabiana, Esher, Shannon K., Ost, Kyla S., Pianalto, Kaila, Nichols, Connie B., Fernandes, Larissa, Bocca, Anamélia L., Poças-Fonseca, Marcio José, Alspaugh, J. Andrew

“…The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic changes to promote its survival in specific ecological niches and inside the host…”
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Campafungins: Inhibitors of Candida albicans and Cryptococcus neoformans Hyphal Growth by Perlatti, Bruno, Harris, Guy, Nichols, Connie B, Ekanayake, Dulamini I, Alspaugh, J. Andrew, Gloer, James B, Bills, Gerald F

“…Campafungin A is a polyketide that was recognized in the Candida albicans fitness test due to its antiproliferative and antihyphal activity. Its mode of action…”
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Extension of O -Linked Mannosylation in the Golgi Apparatus Is Critical for Cell Wall Integrity Signaling and Interaction with Host Cells in Cryptococcus neoformans Pathogenesis by Thak, Eun Jung, Son, Ye Ji, Lee, Dong-Jik, Kim, Hyunah, Kim, Jung Ho, Lee, Su-Bin, Jang, Yu-Byeong, Bahn, Yong-Sun, Nichols, Connie B, Alspaugh, J Andrew, Kang, Hyun Ah

“…The human-pathogenic yeast Cryptococcus neoformans assembles two types of -linked glycans on its proteins. In this study, we identified and functionally…”
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Anti-cryptococcal activity of preussolides A and B, phosphoethanolamine-substituted 24-membered macrolides, and leptosin C from coprophilous isolates of Preussia typharum by Perlatti, Bruno, Lan, Nan, Xiang, Meichun, Earp, Cody E, Spraker, Joseph E, Harvey, Colin J B, Nichols, Connie B, Alspaugh, J Andrew, Gloer, James B, Bills, Gerald F

“…Cryptococcus neoformans is a serious human pathogen with limited options for treatment. We have interrogated extracts from fungal fermentations to find…”
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Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp by Dischler, Nicole M, Xu, Lijian, Li, Yan, Nichols, Connie B, Alspaugh, J. Andrew, Bills, Gerald F, Gloer, James B

“…In the course of our studies of coprophilous fungi as sources of antifungal agents, a strain of an undescribed species in the genus Niesslia (TTI-0426) was…”
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Identification of the Antifungal Metabolite Chaetoglobosin P From Discosia rubi Using a Cryptococcus neoformans Inhibition Assay: Insights Into Mode of Action and Biosynthesis by Perlatti, Bruno, Nichols, Connie B., Lan, Nan, Wiemann, Philipp, Harvey, Colin J. B., Alspaugh, J. Andrew, Bills, Gerald F.

“…Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find…”
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A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis by Telzrow, Calla L, Nichols, Connie B, Castro-Lopez, Natalia, Wormley, Jr, Floyd L, Alspaugh, J Andrew

“…Arrestins, a structurally specialized and functionally diverse group of proteins, are central regulators of adaptive cellular responses in eukaryotes. Previous…”
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Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans by Nichols, Connie B, Ost, Kyla S, Grogan, Dayton P, Pianalto, Kaila, Hasan, Shirin, Alspaugh, J Andrew

“…The localization and specialized function of Ras-like proteins are largely determined by posttranslational processing events. In a highly regulated process,…”
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Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from Sphaerostilbella toxica by Perlatti, Bruno, Nichols, Connie B, Alspaugh, J Andrew, Gloer, James B, Bills, Gerald F

“…is a mycoparasitic fungus that can be found parasitizing wood-decay basidiomycetes in the southern USA. Organic solvent extracts of fermented strains of…”
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Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans by Ballou, Elizabeth Ripley, Selvig, Kyla, Narloch, Jessica L., Nichols, Connie B., Alspaugh, J. Andrew

“…•A whole genome analysis of C. neoformans paralogs revealed a second Rac, Rac2.•Rac paralogs contribute to yeast cell size and exhibit Ras-dependent…”
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Recapitulation of the Sexual Cycle of the Primary Fungal Pathogen Cryptococcus neoformans var. gattii: Implications for an Outbreak on Vancouver Island, Canada by Fraser, James A, Subaran, Ryan L, Nichols, Connie B, Heitman, Joseph

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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