Search Results - "Nichols, Anne"

The cellular basis of fibrotic tendon healing: challenges and opportunities by Nichols, Anne E.C., Best, Katherine T., Loiselle, Alayna E.

“…Tendon injuries are common and can dramatically impair patient mobility and productivity, resulting in a significant socioeconomic burden and reduced quality…”
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Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing by Nichols, Anne E. C., Oh, Irvin, Loiselle, Alayna E.

“…ABSTRACT Over 300,000 tendon repairs are performed annually in the United States to repair damage to tendons as a result of either acute trauma or chronic…”
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Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype by Korcari, Antonion, Nichols, Anne E C, Buckley, Mark R, Loiselle, Alayna E

“…Aged tendons have disrupted homeostasis, increased injury risk, and impaired healing capacity. Understanding mechanisms of homeostatic disruption is crucial…”
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CCR2 is expressed by tendon resident macrophage and T cells, while CCR2 deficiency impairs tendon healing via blunted involvement of tendon‐resident and circulating monocytes/macrophages by Muscat, Samantha, Nichols, Anne E. C., Gira, Emma, Loiselle, Alayna E.

“…During tendon healing, macrophages are thought to be a key mediator of scar tissue formation, which prevents successful functional restoration of the tendon…”
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Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing by Ackerman, Jessica E., Muscat, Samantha N., Adjei-Sowah, Emmanuela, Korcari, Antonion, Nichols, Anne E.C., Buckley, Mark R., Loiselle, Alayna E.

“…•Periostin-lineage cells contribute to a transient but not persistent myofibroblast population.•Periostin serves as a supportive niche for myofibroblast…”
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NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival by Best, Katherine T, Nichols, Anne E C, Knapp, Emma, Hammert, Warren C, Ketonis, Constantinos, Jonason, Jennifer H, Awad, Hani A, Loiselle, Alayna E

“…Although inflammation is necessary during the early phases of tissue repair, persistent inflammation contributes to fibrosis. Acute tendon injuries often heal…”
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Pharmacological antagonism of Ccr2+ cell recruitment to facilitate regenerative tendon healing by Smolyak, Gilbert, Rodenhouse, Andrew, Nichols, Anne E C, Ketonis, Constantinos, Loiselle, Alayna E

“…Successful tendon healing requires sufficient deposition and remodeling of new extracellular matrix at the site of injury, with this process mediating in part…”
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Impact of isolation method on cellular activation and presence of specific tendon cell subpopulations during in vitro culture by Nichols, Anne E. C., Muscat, Samantha N., Miller, Sarah E., Green, Luke J., Richards, Michael S., Loiselle, Alayna E.

“…Tendon injuries are common and heal poorly, due in part to a lack of understanding of fundamental tendon cell biology. A major impediment to the study of…”
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Correction: Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype by Korcari, Antonion, Nichols, Anne E C, Buckley, Mark R, Loiselle, Alayna E

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Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis by Best, Katherine T, Korcari, Antonion, Mora, Keshia E, Nichols, Anne Ec, Muscat, Samantha N, Knapp, Emma, Buckley, Mark R, Loiselle, Alayna E

“…Despite the requirement for -lineage (Scx ) cells during tendon development, the function of Scx cells during adult tendon repair, post-natal growth, and adult…”
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Telephone-Based Intervention to Improve Family Planning Care in Pregnancies of Unknown Location: Retrospective Pre-Post Study by Flynn, Anne Nichols, Koelper, Nathanael C, Sonalkar, Sarita

“…Background:Patients followed for a pregnancy of unknown location are generally followed by a team of clinicians through telephone calls, and their…”
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Cell non-autonomous functions of S100a4 drive fibrotic tendon healing by Ackerman, Jessica E, Nichols, Anne Ec, Studentsova, Valentina, Best, Katherine T, Knapp, Emma, Loiselle, Alayna E

“…Identification of pro-regenerative approaches to improve tendon healing is critically important as the fibrotic healing response impairs physical function. In…”
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Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function by Ackerman, Jessica E, Best, Katherine T, Muscat, Samantha N, Pritchett, Elizabeth M, Nichols, Anne E C, Wu, Chia-Lung, Loiselle, Alayna E

“…Tendon injuries heal via a scar-mediated response, and there are no biological approaches to promote more regenerative healing. Mouse flexor tendons heal…”
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A novel murine muscle loading model to investigate Achilles musculotendinous adaptation by Rezvani, Sabah N, Nichols, Anne E C, Grange, Robert W, Dahlgren, Linda A, Brolinson, P Gunnar, Wang, Vincent M

“…Achilles tendinopathy is a debilitating condition affecting the entire spectrum of society and a condition that increases the risk of tendon rupture. Effective…”
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Leveraging in vivo animal models of tendon loading to inform tissue engineering approaches by Muscat, Samantha, Nichols, Anne E C

“…Tendon injuries disrupt successful transmission of force between muscle and bone, resulting in reduced mobility, increased pain, and significantly reduced…”
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Adipose‐Derived Stromal Vascular Fraction and Cultured Stromal Cells as Trophic Mediators for Tendon Healing by Polly, Shelley S., Nichols, Anne E. C., Donnini, Elle, Inman, Daniel J., Scott, Timothy J., Apple, Stephanie M., Werre, Stephen R., Dahlgren, Linda A.

“…ABSTRACT Adipose‐derived stromal vascular fraction (SVF) is a heterogeneous population of cells that yields a homogeneous population of plastic‐adherent…”
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Effects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen‐inducible mouse models by Best, Katherine T., Studentsova, Valentina, Ackerman, Jessica E., Nichols, Anne E. C., Myers, Marlin, Cobb, Justin, Knapp, Emma, Awad, Hani A., Loiselle, Alayna E.

“…The use of tamoxifen‐inducible models of Cre recombinase in the tendon field is rapidly expanding, resulting in an enhanced understanding of tendon homeostasis…”
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Urinary Bladder Matrix Does Not Improve Tenogenesis in an In Vitro Equine Model by Khatibzadeh, Sarah M., Menarim, Bruno C., Nichols, Anne E. C., Werre, Stephen R., Dahlgren, Linda A.

“…ABSTRACT Extracellular matrix (ECM) is responsible for tendon strength and elasticity. Healed tendon ECM lacks structural integrity, leading to reinjury…”
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Urinary bladder matrix does not improve tenogenesis in an in vitro equine model by Khatibzadeh, Sarah M, Menarim, Bruno C, Nichols, Anne Ec, Werre, Stephen R, Dahlgren, Linda A

“…Extracellular matrix (ECM) is responsible for tendon strength and elasticity. Healed tendon ECM lacks structural integrity, leading to reinjury. Porcine…”
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Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing by Adjei-Sowah, Emmanuela, Chandrasiri, Indika, Xiao, Baixue, Liu, Yuxuan, Ackerman, Jessica E, Soto, Celia, Nichols, Anne E C, Nolan, Katherine, Benoit, Danielle S W, Loiselle, Alayna E

“…Satisfactory healing following acute tendon injury is marred by fibrosis. Despite the high frequency of tendon injuries and poor outcomes, there are no…”
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