Identification of chromosomal regions involved in decapentaplegic function in drosophila

Signaling molecules of the transforming growth factor beta (TGF-beta) family contribute to numerous developmental processes in a variety of organisms. However, our understanding of the mechanisms which regulate the activity of and mediate the response to TGF-beta family members remains incomplete. T...

Full description

Saved in:

Bibliographic Details
Published in:	Genetics (Austin) Vol. 149; no. 1; pp. 203 - 215
Main Authors:	Nicholls, R.E, Gelbart, W.M
Format:	Journal Article
Language:	English
Published:	United States Genetics Soc America 01-05-1998 Genetics Society of America
Subjects:	AILE ALAS ALLELES ANIMAL CUTICLE Animals Bacterial Proteins - genetics BLOOD VEINS CELL DIFFERENTIATION CHROMOSOMAL DEFICIENCIES Chromosome Mapping CUTICULA ANIMAL CUTICULE ANIMALE DIFERENCIACION CELULAR DIFFERENCIATION CELLULAIRE DNA-Binding Proteins - genetics DPP LOCUS DROSOPHILA MELANOGASTER Drosophila Proteins FACTEUR DE CROISSANCE TRANSFORMANT FACTOR DE CRECIMIENTO TRANSFORMANTE FENOTIPOS GENE GENE INTERACTION GENE RECESSIF GENES GENES RECESIVOS Genetics INDUCED MUTATION Insect Proteins - genetics Insect Proteins - physiology Insects INTERACCION DE GENES INTERACTION GENIQUE LARVAE LARVAS LARVE LOCI LOCUS Molecular biology MUTACION INDUCIDA MUTATION PROVOQUEE PHENOTYPE PHENOTYPES RECESSIVE GENES RECESSIVE LETHALS SEGREGACION SEGREGATION Sequence Deletion Tolloid-Like Metalloproteinases Trans-Activators Transcription Factors TRANSFORMING GROWTH FACTOR Transforming Growth Factor beta - genetics VEINE VENAS WINGS
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Signaling molecules of the transforming growth factor beta (TGF-beta) family contribute to numerous developmental processes in a variety of organisms. However, our understanding of the mechanisms which regulate the activity of and mediate the response to TGF-beta family members remains incomplete. The product of the Drosophila decapentaplegic (dpp) locus is a well-characterized member of this family. We have taken a genetic approach to identify factors required for TGF-beta function in Drosophila by testing for genetic interactions between mutant alleles of dpp and a collection of chromosomal deficiencies. Our survey identified two deficiencies that act as maternal enhancers of recessive embryonic lethal alleles of dpp. The enhanced individuals die with weakly ventralized phenotypes. These phenotypes are consistent with a mechanism whereby the deficiencies deplete two maternally provided factors required for dpp's role in embryonic dorsal-ventral pattern formation. One of these deficiencies also appears to delete a factor required for dpp function in wing vein formation. These deficiencies remove material from the 54F-55A and 66B-66C polytene chromosomal regions, respectively. As neither of these regions has been previously implicated in dpp function, we propose that each of the deficiencies removes a novel factor or factors required for dpp function.
Bibliography:	L50 1997067214 L10 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0016-6731 1943-2631 1943-2631
DOI:	10.1093/genetics/149.1.203