Search Results - "Nicholls, Hayley T."

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding by Vogt, Merly C., Paeger, Lars, Hess, Simon, Steculorum, Sophie M., Awazawa, Motoharu, Hampel, Brigitte, Neupert, Susanne, Nicholls, Hayley T., Mauer, Jan, Hausen, A. Christine, Predel, Reinhard, Kloppenburg, Peter, Horvath, Tamas L., Brüning, Jens C.

“…Maternal metabolic homeostasis exerts long-term effects on the offspring’s health outcomes. Here, we demonstrate that maternal high-fat diet (HFD) feeding…”
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Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance by Turpin, Sarah M., Nicholls, Hayley T., Willmes, Diana M., Mourier, Arnaud, Brodesser, Susanne, Wunderlich, Claudia M., Mauer, Jan, Xu, Elaine, Hammerschmidt, Philipp, Brönneke, Hella S., Trifunovic, Aleksandra, LoSasso, Giuseppe, Wunderlich, F. Thomas, Kornfeld, Jan-Wilhelm, Blüher, Matthias, Krönke, Martin, Brüning, Jens C.

“…Ceramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide…”
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Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b by Kornfeld, Jan-Wilhelm, Baitzel, Catherina, Könner, A. Christine, Nicholls, Hayley T., Vogt, Merly C., Herrmanns, Karolin, Scheja, Ludger, Haumaitre, Cécile, Wolf, Anna M., Knippschild, Uwe, Seibler, Jost, Cereghini, Silvia, Heeren, Joerg, Stoffel, Markus, Brüning, Jens C.

“…The livers of obese mice and humans show increased levels of miR-802 resulting in impaired glucose tolerance and decreased insulin sensitivity through…”
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Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice by Krisko, Tibor I., Nicholls, Hayley T., Bare, Curtis J., Holman, Corey D., Putzel, Gregory G., Jansen, Robert S., Sun, Natalie, Rhee, Kyu Y., Banks, Alexander S., Cohen, David E.

“…Recent studies suggest that a key mechanism whereby the gut microbiome influences energy balance and glucose homeostasis is through the recruitment of brown…”
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Up‐regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice by Imai, Norihiro, Nicholls, Hayley T., Alves‐Bezerra, Michele, Li, Yingxia, Ivanova, Anna A., Ortlund, Eric A., Cohen, David E.

“…Background and Aims Thioesterase superfamily member 2 (Them2) is highly expressed in liver and oxidative tissues, where it hydrolyzes long‐chain fatty acyl‐CoA…”
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Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice by Li, Yue, Imai, Norihiro, Nicholls, Hayley T., Roberts, Blaine R., Goyal, Samaksh, Krisko, Tibor I., Ang, Lay-Hong, Tillman, Matthew C., Roberts, Anne M., Baqai, Mahnoor, Ortlund, Eric A., Cohen, David E., Hagen, Susan J.

“…In brown adipose tissue, thermogenesis is suppressed by thioesterase superfamily member 1 (Them1), a long chain fatty acyl-CoA thioesterase. Them1 is highly…”
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CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity by Hammerschmidt, Philipp, Ostkotte, Daniela, Nolte, Hendrik, Gerl, Mathias J., Jais, Alexander, Brunner, Hanna L., Sprenger, Hans-Georg, Awazawa, Motoharu, Nicholls, Hayley T., Turpin-Nolan, Sarah M., Langer, Thomas, Krüger, Marcus, Brügger, Britta, Brüning, Jens C.

“…Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of obesity and insulin resistance. However, the mechanistic link…”
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IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade by Lancaster, Graeme I, Skiba, Beata, Yang, Christine, Nicholls, Hayley T, Langley, Katherine G, Chan, M H Stanley, Bruce, Clinton R, Rewcastle, Gordon W, Shepherd, Peter R, Karin, Michael, Febbraio, Mark A

“…In the present study, we have examined whether IKKβ [IκB (inhibitor of nuclear factor κB) kinase β] plays a role in feedback inhibition of the insulin…”
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Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy by Tholen, Stefan, Patel, Roma, Agas, Agnieszka, Kovary, Kyle M, Rabiee, Atefeh, Nicholls, Hayley T, Bielczyk-Maczyńska, Ewa, Yang, Wenting, Kraemer, Fredric B, Teruel, Mary N

“…Disruption of circadian glucocorticoid oscillations in Cushing's disease and chronic stress results in obesity and adipocyte hypertrophy, which is believed to…”
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Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis by Nicholls, Hayley T, Hornick, Jason L, Cohen, David E

“…Mice fed a methionine- and choline-deficient (MCD) diet develop steatohepatitis that recapitulates key features of nonalcoholic steatohepatitis (NASH) in…”
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Hematopoietic Cell―Restricted Deletion of CD36 Reduces High-Fat Diet―Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue by NICHOLLS, Hayley T, KOWALSKI, Greg, FEBBRAIO, Maria, LANCASTER, Graeme I, FEBBRAIO, Mark A, KENNEDY, David J, RISIS, Steve, ZAFFINO, Lee A, WATSON, Nadine, KANELLAKIS, Peter, WATT, Matthew J, BOBIK, Alex, BONEN, Arend

“…The fatty acid translocase and scavenger receptor CD36 is important in the recognition and uptake of lipids. Accordingly, we hypothesized that it plays a role…”
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Hepatology Highlights by Imai, Norihiro, Krisko, Tibor I., Tafesh, Zaid H., Lucero, Catherine, Alves‐Bezerra, Michele, Nicholls, Hayley T., Steensels, Sandra, Ersoy, Baran A., Rosenblatt, Russell, Schwartz, Robert E., Gupta, Vikas, Lominadze, Zurabi, Fortune, Brett E., Brown, Robert S.

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Hepatology Highlights by Russo, Nicholas, Brown, Robert S., Shah, Shawn L., Krisko, Tibor I., Krumm, Christopher S., Nicholls, Hayley T., Mousa, Omar, Malhi, Harmeet, Schwartz, Robert E., Lominadze, Zurabi, Rosenblatt, Russell, Fortune, Brett E., Pisa, Joseph F., Jesudian, Arun B., Gupta, Vikas, Tafesh, Zaid H.

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Hepatology Highlights by Russo, Nicholas, Jesudian, Arun, Shen, Nicole T., Brown, Robert S., Sugiyama, Akiko, Nicholls, Hayley T., Pisa, Joseph F., Krisko, Tibor I., Rosenblatt, Russell, Tafesh, Zaid H., Fortune, Brett E., Mousa, Omar, Malhi, Harmeet, Schwartz, Robert E., Gupta, Vikas, Kulai, Tasha B., Malhi, Harmeet

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Hepatology Highlights by Mousa, Omar, Malhi, Harmeet, Schwartz, Robert E., Kulai, Tasha B., Trivedi, Hirsh D., Lau, Daryl T.Y., Shen, Nicole T., Brown, Robert S., Hirsova, Petra, Xu, Xu, Nicholls, Hayley T., Pisa, Joseph F., Tafesh, Zaid H., Fortune, Brett E., Gupta, Vikas, Kostallari, Enis, Russo, Nicholas, Jesudian, Arun B.

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Hepatology Highlights by Shen, Nicole T., Brown, Robert S., Imai, Norihiro, Krisko, Tibor I., Alves‐Bezerra, Michele, Nicholls, Hayley T., Kulai, Tasha B, Schwartz, Robert E., Russo, Nicholas, Lucero, Catherine, Tafesh, Zaid H., Jesudian, Arun, Rosenblatt, Russell, Fortune, Brett E., Pisa, Joseph F., Mousa, Omar, Malhi, Harmeet, Gupta, Vikas

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Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance by Imai, Norihiro, Nicholls, Hayley T., Alves-Bezerra, Michele, Li, Yingxia, Ivanova, Anna A., Ortlund, Eric A., Cohen, David E.

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Corporate or commercial? Considering modes of ceramic roof tile production in Chichester in the medieval and beyond by Nicholls, Hayley, Regensberg, Rae

“…Medieval tileries, their mode of production and development are still very poorly understood. This research update combines historic and recent excavation…”
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Thioesterase Superfamily Member 1 Undergoes Stimulus‐coupled Reorganization to Regulate Metabolic Activity in Brown Adipose Tissue by Li, Yue, Imai, Norihiro, Goyal, Samaksh, Nicholls, Hayley T., Krisko, Tibor, Baqai, Mahnoor, Ang, Lay-Hong, Tillman, Matthew, Ortlund, Eric A., Cohen, David E., Hagen, Susan J.

“…Abstract only Thioesterase superfamily member 1 (Them1) is a long chain fatty acyl‐CoA thioesterase that is enriched in brown adipose tissue. Them1 is markedly…”
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Su1597 PORTAL VEIN METABOLITE PROFILING REVEALS MICROBIOME-DEPENDENT METABOLIC CONTROL OF HEPATIC GLUCONEOGENESIS: IMPLICATIONS FOR OBESITY-RELATED METABOLIC DISORDERS by Krisko, Tibor, Nicholls, Hayley T., Banks, Alexander S., Cohen, David

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