Search Results - "Nicholls, B."

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain by Takeda, Shuko, Wegmann, Susanne, Cho, Hansang, DeVos, Sarah L., Commins, Caitlin, Roe, Allyson D., Nicholls, Samantha B., Carlson, George A., Pitstick, Rose, Nobuhara, Chloe K., Costantino, Isabel, Frosch, Matthew P., Müller, Daniel J., Irimia, Daniel, Hyman, Bradley T.

“…Tau pathology is known to spread in a hierarchical pattern in Alzheimer’s disease (AD) brain during disease progression, likely by trans-synaptic tau transfer…”
Get full text

Ultrasound in regional anaesthesia by Griffin, J., Nicholls, B.

“…Summary Ultrasound guidance is rapidly becoming the gold standard for regional anaesthesia. There is an ever growing weight of evidence, matched with improving…”
Get full text

Astronomy. ASASSN-15lh: A highly super-luminous supernova by Dong, Subo, Shappee, B J, Prieto, J L, Jha, S W, Stanek, K Z, Holoien, T W-S, Kochanek, C S, Thompson, T A, Morrell, N, Thompson, I B, Basu, U, Beacom, J F, Bersier, D, Brimacombe, J, Brown, J S, Bufano, F, Chen, Ping, Conseil, E, Danilet, A B, Falco, E, Grupe, D, Kiyota, S, Masi, G, Nicholls, B, Olivares E, F, Pignata, G, Pojmanski, G, Simonian, G V, Szczygiel, D M, Woźniak, P R

“…We report the discovery of ASASSN-15lh (SN 2015L), which we interpret as the most luminous supernova yet found. At redshift z = 0.2326, ASASSN-15lh reached an…”
Get full text

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation by Nicholls, Samantha B, DeVos, Sarah L, Commins, Caitlin, Nobuhara, Chloe, Bennett, Rachel E, Corjuc, Diana L, Maury, Eduardo, Eftekharzadeh, Bahareh, Akingbade, Ololade, Fan, Zhanyun, Roe, Allyson D, Takeda, Shuko, Wegmann, Susanne, Hyman, Bradley T

“…The spread of neurofibrillary tangle (NFT) pathology through the human brain is a hallmark of Alzheimer's disease (AD), which is thought to be caused by the…”
Get full text

ASASSN-15lh: A highly super-luminous supernova by Dong, Subo, Shappee, B. J., Prieto, J. L., Jha, S. W., Stanek, K. Z., Holoien, T. W.-S., Kochanek, C. S., Thompson, T. A., Morrell, N., Thompson, I. B., Basu, U., Beacom, J. F., Bersier, D., Brimacombe, J., Brown, J. S., Bufano, F., Chen, Ping, Conseil, E., Danilet, A. B., Falco, E., Grupe, D., Kiyota, S., Masi, G., Nicholls, B., E, F. Olivares, Pignata, G., Pojmanski, G., Simonian, G. V., Szczygiel, D. M., Woźniak, P. R.

“…We report the discovery of ASASSN-15lh (SN 2015L), which we interpret as the most luminous supernova yet found. At redshift z = 0.2326, ASASSN-15lh reached an…”
Get full text

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients by Takeda, Shuko, Commins, Caitlin, DeVos, Sarah L., Nobuhara, Chloe K., Wegmann, Susanne, Roe, Allyson D., Costantino, Isabel, Fan, Zhanyun, Nicholls, Samantha B., Sherman, Alexis E., Trisini Lipsanopoulos, Ana T., Scherzer, Clemens R., Carlson, George A., Pitstick, Rose, Peskind, Elaine R., Raskind, Murray A., Li, Ge, Montine, Thomas J., Frosch, Matthew P., Hyman, Bradley T.

“…Objective Cerebrospinal fluid (CSF) tau is an excellent surrogate marker for assessing neuropathological changes that occur in Alzheimer's disease (AD)…”
Get full text

The ASAS-SN bright supernova catalogue – IV. 2017 by Holoien, T W-S, Brown, J S, Vallely, P J, Stanek, K Z, Kochanek, C S, Shappee, B J, Prieto, J L, Dong, Subo, Brimacombe, J, Bishop, D W, Bose, S, Beacom, J F, Bersier, D, Chen, Ping, Chomiuk, L, Falco, E, Holmbo, S, Jayasinghe, T, Morrell, N, Pojmanski, G, Shields, J V, Strader, J, Stritzinger, M D, Thompson, Todd A, Woźniak, P R, Bock, G, Cacella, P, Carballo, J G, Cruz, I, Conseil, E, Farfan, R G, Fernandez, J M, Kiyota, S, Koff, R A, Krannich, G, Marples, P, Masi, G, Monard, L A G, Muñoz, J A, Nicholls, B, Post, R S, Stone, G, Trappett, D L, Wiethoff, W S

Get full text

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease by Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose, Beier, David R, Carlson, George A, Spires-Jones, Tara L, Hyman, Bradley T

“…In early stages of Alzheimer's disease (AD), neurofibrillary tangles (NFT) are largely restricted to the entorhinal cortex and medial temporal lobe. At later…”
Get full text

The ASAS-SN bright supernova catalogue – I. 2013–2014 by Holoien, T W-S, Stanek, K Z, Kochanek, C S, Shappee, B J, Prieto, J L, Brimacombe, J, Bersier, D, Bishop, D W, Dong, Subo, Brown, J S, Danilet, A B, Simonian, G V, Basu, U, Beacom, J F, Falco, E, Pojmanski, G, Skowron, D M, Wozniak, P R, Avila, C G, Conseil, E, Contreras, C, Cruz, I, Fernandez, J M, Koff, R A, Guo, Zhen, Herczeg, G J, Hissong, J, Hsiao, E Y, Jose, J, Kiyota, S, Long, Feng, Monard, L AG, Nicholls, B, Nicolas, J, Wiethoff, W S

“…We present basic statistics for all supernovae discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN) during its first year-and-a-half of…”
Get full text

Contrasting Home-Range Size and Spatial Partitioning in Cryptic and Sympatric Pipistrelle Bats by Nicholls, B., Racey, P. A.

“…The extent of spatial partitioning in insectivorous bats, whose prey is patchily distributed and transient in nature, remains a contentious issue. The recent…”
Get full text

Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants by Beck, Alain, Nowak, Christine, Meshulam, Deborah, Reynolds, Kristina, Chen, David, Pacardo, Dennis B, Nicholls, Samantha B, Carven, Gregory J, Gu, Zhenyu, Fang, Jing, Wang, Dongdong, Katiyar, Amit, Xiang, Tao, Liu, Hongcheng

“…Since the first approval of the anti-CD3 recombinant monoclonal antibody (mAb), muromonab-CD3, a mouse antibody for the prevention of transplant rejection, by…”
Get full text

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model by Polydoro, Manuela, Dzhala, Volodymyr I., Pooler, Amy M., Nicholls, Samantha B., McKinney, A. Patrick, Sanchez, Laura, Pitstick, Rose, Carlson, George A., Staley, Kevin J., Spires-Jones, Tara L., Hyman, Bradley T.

“…Neurofibrillary tangles (NFTs), a hallmark of Alzheimer’s disease, are intracellular silver and thioflavin S-staining aggregates that emerge from earlier…”
Get full text

Mechanism of a Genetically Encoded Dark-to-Bright Reporter for Caspase Activity by Nicholls, Samantha B., Chu, Jun, Abbruzzese, Genevieve, Tremblay, Kimberly D., Hardy, Jeanne A.

“…Fluorescent proteins have revolutionized modern biology with their ability to report the presence of tagged proteins in living systems. Although several…”
Get full text

Best practices for safety and quality in peripheral regional anaesthesia by Topor, B., Oldman, M., Nicholls, B.

Get full text

Structural basis of fluorescence quenching in caspase activatable‐GFP by Nicholls, Samantha B., Hardy, Jeanne A.

“…Apoptosis is critical for organismal homeostasis and a wide variety of diseases. Caspases are the ultimate executors of the apoptotic programmed cell death…”
Get full text

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice by El Khoury, Noura B, Gratuze, Maud, Petry, Franck, Papon, Marie-Amélie, Julien, Carl, Marcouiller, François, Morin, Françoise, Nicholls, Samantha B, Calon, Frédéric, Hébert, Sébastien S, Marette, André, Planel, Emmanuel

“…Abstract Accumulating evidence from epidemiological studies suggest that type 2 diabetes is linked to an increased risk of Alzheimer's disease (AD). However,…”
Get full text

A Tunable, Modular Approach to Fluorescent Protease-Activated Reporters by Wu, Peng, Nicholls, Samantha B., Hardy, Jeanne A.

“…Proteases are one of the most important and historically utilized classes of drug targets. To effectively interrogate this class of proteins, which encodes…”
Get full text

Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets by Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T

“…Accumulation and aggregation of the microtubule-associated protein tau are a pathological hallmark of neurodegenerative disorders such as Alzheimer's disease…”
Get full text

Massive stars exploding in a He-rich circumstellar medium – VII. The metamorphosis of ASASSN-15ed from a narrow line Type Ibn to a normal Type Ib Supernova by Pastorello, A., Prieto, J. L., Elias-Rosa, N., Bersier, D., Hosseinzadeh, G., Morales-Garoffolo, A., Noebauer, U. M., Taubenberger, S., Tomasella, L., Kochanek, C. S., Falco, E., Basu, U., Beacom, J. F., Benetti, S., Brimacombe, J., Cappellaro, E., Danilet, A. B., Dong, Subo, Fernandez, J. M., Goss, N., Granata, V., Harutyunyan, A., Holoien, T. W.-S., Ishida, E. E. O., Kiyota, S., Krannich, G., Nicholls, B., Ochner, P., Pojmański, G., Shappee, B. J., Simonian, G. V., Stanek, K. Z., Starrfield, S., Szczygieł, D., Tartaglia, L., Terreran, G., Thompson, T. A., Turatto, M., Wagner, R. M., Wiethoff, W. S., Wilber, A., Woźniak, P. R.

“…We present the results of the spectroscopic and photometric monitoring campaign of ASASSN-15ed. The transient was discovered quite young by the All Sky…”
Get full text

Ultrasound‐guided approach to nerves (direct vs. tangential) and the incidence of intraneural injection: a cadaveric study by Sermeus, L. A., Sala‐Blanch, X., McDonnell, J. G., Lobo, C. A., Nicholls, B. J., Geffen, G. J., Choquet, O., Iohom, G., Jose Maria Galve, B., Hermans, C., Lammens, M.

“…Summary This study evaluated the incidence of nerve puncture and intraneural injection based on the needle approach to the nerve (direct vs. tangential). Two…”
Get full text