Search Results - "Nicholas T. Ventham"

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics by Ventham, Nicholas T, Kennedy, Nicholas A, Nimmo, Elaine R, Satsangi, Jack

“…In the past decade, there have been fundamental advances in our understanding of genetic factors that contribute to the inflammatory bowel diseases (IBDs)…”
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Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD by Boyapati, Ray K, Dorward, David A, Tamborska, Arina, Kalla, Rahul, Ventham, Nicholas T, Doherty, Mary K, Whitfield, Philip D, Gray, Mohini, Loane, Joseph, Rossi, Adriano G, Satsangi, Jack, Ho, Gwo-tzer

“…Abstract Background Due to common evolutionary origins, mitochondrial DNA (mtDNA) shares many similarities with immunogenic bacterial DNA. MtDNA is recognized…”
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Serum Calprotectin: A Novel Diagnostic and Prognostic Marker in Inflammatory Bowel Diseases by Kalla, Rahul, Kennedy, Nicholas A, Ventham, Nicholas T, Boyapati, Ray K, Adams, Alex T, Nimmo, Elaine R, Visconti, Micaela R, Drummond, Hazel, Ho, Gwo-Tzer, Pattenden, Rebecca J, Wilson, David C, Satsangi, Jack

“…There is an unmet need for novel blood-based biomarkers that offer timely and accurate diagnostic and prognostic testing in inflammatory bowel diseases (IBD)…”
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Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease by Zhang, Han, Kalla, Rahul, Chen, Jie, Zhao, Jianhui, Zhou, Xuan, Adams, Alex, Noble, Alexandra, Ventham, Nicholas T., Wellens, Judith, Ho, Gwo-Tzer, Dunlop, Malcolm G., Nowak, Jan Krzysztof, Ding, Yuan, Liu, Zhanju, Satsangi, Jack, Theodoratou, Evropi, Li, Xue

“…This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian…”
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Acute colonic obstruction within a congenital Bochdalek diaphragmatic hernia following colonoscopy by Ventham, Nicholas T., Zanellato, Artur, McKechnie, Peter Stuart

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Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease by Klasić, Marija, Markulin, Dora, Vojta, Aleksandar, Samaržija, Ivana, Biruš, Ivan, Dobrinić, Paula, Ventham, Nicholas T, Trbojević-Akmačić, Irena, Šimurina, Mirna, Štambuk, Jerko, Razdorov, Genadij, Kennedy, Nicholas A, Satsangi, Jack, Dias, Ana M, Pinho, Salome, Annese, Vito, Latiano, Anna, D'Inca, Renata, Lauc, Gordan, Zoldoš, Vlatka

“…Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD)…”
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An Unusual Cause of Rectal Pain by Leow, Hui Wei, Coupland, Alexander, Ventham, Nicholas T.

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Correction: changes to serum sample tube and processing methodology does not cause inter-individual variation in automated whole serum N-glycan profiling in health and disease by Ventham, Nicholas T, Gardner, Richard A, Kennedy, Nicholas A, Shubhakar, Archana, Kalla, Rahul, Nimmo, Elaine R, Fernandes, Daryl L, Satsangi, Jack, Spencer, Daniel I R

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Analgesia after open abdominal surgery in the setting of enhanced recovery surgery: a systematic review and meta-analysis by Hughes, Michael J, Ventham, Nicholas T, McNally, Stephen, Harrison, Ewen, Wigmore, Stephen

“…The optimal analgesic technique following open abdominal surgery within an enhanced recovery protocol remains controversial. Thoracic epidural is often…”
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Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis by Gasparetto, Marco, Payne, Felicity, Nayak, Komal, Kraiczy, Judith, Glemas, Claire, Philip-McKenzie, Yosef, Ross, Alexander, Edgar, Rachel D., Zerbino, Daniel R., Salvestrini, Camilla, Torrente, Franco, Ventham, Nicholas T., Kalla, Rahul, Satsangi, Jack, Sarkies, Peter, Heuschkel, Robert, Zilbauer, Matthias

“…Gene expression patterns of CD8+ T cells have been reported to correlate with clinical outcomes of adults with inflammatory bowel diseases (IBD). We aimed to…”
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Central venous pressure and liver resection: a systematic review and meta analysis by Hughes, Michael J, Ventham, Nicholas T, Harrison, Ewen M, Wigmore, Stephen J

“…Abstract Background A liver resection under low central venous pressure (CVP) has become standard practice; however, the benefits beyond a reduction in blood…”
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Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome by Trbojević Akmačić, Irena, Ventham, Nicholas T, Theodoratou, Evropi, Vučković, Frano, Kennedy, Nicholas A, Krištić, Jasminka, Nimmo, Elaine R, Kalla, Rahul, Drummond, Hazel, Štambuk, Jerko, Dunlop, Malcolm G, Novokmet, Mislav, Aulchenko, Yurii, Gornik, Olga, Campbell, Harry, Pučić Baković, Maja, Satsangi, Jack, Lauc, Gordan

“…Glycobiology is an underexplored research area in inflammatory bowel disease (IBD), and glycans are relevant to many etiological mechanisms described in IBD…”
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Crohn’s disease by Kalla, Rahul, Ventham, Nicholas T, Satsangi, Jack, Arnott, Ian D R

“…Crohn's disease is a chronic inflammatory disorder that can affect any part of the gastrointestinal tract. Although the disease most commonly presents at a…”
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The role of glycosylation in IBD by Theodoratou, Evropi, Campbell, Harry, Ventham, Nicholas T., Kolarich, Daniel, Pučić-Baković, Maja, Zoldoš, Vlatka, Fernandes, Daryl, Pemberton, Iain K., Rudan, Igor, Kennedy, Nicholas A., Wuhrer, Manfred, Nimmo, Elaine, Annese, Vito, McGovern, Dermot P. B., Satsangi, Jack, Lauc, Gordan

“…Key Points Studies of the role of glycans in IBD are focused on three areas: glycosylation patterns of intestinal mucins, serum glycan levels of glycoproteins…”
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Isolated Transcalcaneal Talonavicular Dislocation: A Severe Injury Related to a Low-energy Mechanism by Ventham, Nicholas T., MRCS (Eng), MBBS, Phadnis, Joideep, MRCS (Eng), Sujenthiran, Arunan, MRCS (Eng), Trompeter, Alex J., MBBS, BSc, FRCS (Tr+Orth), Ramesh, Palanisamy, FRCS

“…Abstract Transcalcaneal talonavicular dislocation is a rare injury, with very few reported cases. Of these, most have been the result of high-energy mechanisms…”
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Efficacy of Intravenous Lidocaine for Postoperative Analgesia Following Laparoscopic Surgery: A Meta-Analysis by Ventham, Nicholas T., Kennedy, Ewan D., Brady, Richard R., Paterson, Hugh M., Speake, Doug, Foo, Irwin, Fearon, Kenneth C. H.

“…Background Intravenous (IV) lidocaine has analgesic and anti-inflammatory properties. This study aims to evaluate the efficacy of IV lidocaine in controlling…”
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Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease by Joustra, Vincent, Hageman, Ishtu L, Satsangi, Jack, Adams, Alex, Ventham, Nicholas T, de Jonge, Wouter J, Henneman, Peter, D'Haens, Geert R, Li Yim, Andrew Y F

“…Over the past decade, the DNA methylome has been increasingly studied in peripheral blood of inflammatory bowel disease [IBD] patients. However, a…”
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Evaluation of Novel Local Anesthetic Wound Infiltration Techniques for Postoperative Pain Following Colorectal Resection Surgery: A Meta-analysis by Ventham, Nicholas T, O’Neill, Stephen, Johns, Neil, Brady, Richard R, Fearon, Kenneth C H

“…BACKGROUND:Novel local anesthetic blocks have become increasingly popular in the multimodal pain management following abdominal surgery, but have not been…”
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Colorectal cancer outcomes in nonagenarian patients: A case series by Au, Stephanie, Ventham, Nicholas T., Yalamarthi, Satheesh, Manimaran, Natarajan

“…Increased life expectancy and improved medical management of co-morbidities has led to an increasing number of nonagenarian patients with colorectal cancer…”
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Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci by Adams, Alex T, Kennedy, Nicholas A, Hansen, Richard, Ventham, Nicholas T, OʼLeary, Kate R, Drummond, Hazel E, Noble, Colin L, El-Omar, Emad, Russell, Richard K, Wilson, David C, Nimmo, Elaine R, Hold, Georgina L, Satsangi, Jack

“…As a result of technological and analytical advances, genome-wide characterization of key epigenetic alterations is now feasible in complex diseases. We…”
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