Search Results - "Nicholas, J. D"
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Methodologies for “Wiring” Redox Proteins/Enzymes to Electrode Surfaces
Published in Chemistry : a European journal (22-08-2018)“…The immobilization of redox proteins or enzymes onto conductive surfaces has application in the analysis of biological processes, the fabrication of…”
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Cutaneous afferent innervation of the human foot sole: what can we learn from single-unit recordings?
Published in Journal of neurophysiology (01-09-2018)“…Cutaneous afferents convey exteroceptive information about the interaction of the body with the environment and proprioceptive information about body position…”
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The effects of acute normobaric hypoxia on standing balance while dual-tasking with and without visual input
Published in European journal of applied physiology (01-08-2024)“…Purpose To investigate the influence of acute normobaric hypoxia on standing balance under single and dual-task conditions, both with and without visual input…”
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A review of the direct targets of the cannabinoids cannabidiol, Δ9-tetrahydrocannabinol, N-arachidonoylethanolamine and 2-arachidonoylglycerol
Published in AIMS neuroscience (01-01-2024)“…Marijuana has been used by humans for thousands of years for both medicinal and recreational purposes. This included the treatment of pain, inflammation,…”
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5
Cutaneous sensitivity in unilateral trans-tibial amputees
Published in PloS one (01-06-2018)“…To examine tactile sensitivity in the leg and foot sole of below-knee amputees (diabetic n = 3, traumatic n = 1), and healthy control subjects (n = 4), and…”
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Using Purely Sinusoidal Voltammetry for Rapid Inference of Surface-Confined Electrochemical Reaction Parameters
Published in Analytical chemistry (Washington) (02-02-2021)“…Alternating current (AC) voltammetric techniques are experimentally powerful as they enable Faradaic current to be isolated from non-Faradaic contributions…”
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Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH
Published in RSC advances (23-01-2024)“…Novel methods to construct small molecule-protein bioconjugates are integral to the development of new biomedicines for a variety of diseases. C-C linked…”
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Pre-Columbian fire management and control of climate-driven floodwaters over 3,500 years in southwestern Amazonia
Published in Proceedings of the National Academy of Sciences - PNAS (05-10-2021)“…In landscapes that support economic and cultural activities, human communities actively manage environments and environmental change at a variety of spatial…”
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Ecological consequences of post-Columbian indigenous depopulation in the Andean–Amazonian corridor
Published in Nature ecology & evolution (01-08-2018)“…European colonization of South America instigated a continental-scale depopulation of its indigenous peoples. The impact of depopulation on the tropical…”
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Cerebrovascular and blood pressure responses during voluntary apneas are larger than rebreathing
Published in European journal of applied physiology (01-03-2022)“…Both voluntary rebreathing (RB) of expired air and voluntary apneas (VA) elicit changes in arterial carbon dioxide and oxygen (CO 2 and O 2 ) chemostimuli…”
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Thresholds of skin sensitivity are partially influenced by mechanical properties of the skin on the foot sole
Published in Physiological reports (01-06-2015)“…Across the foot sole, there are vibration and monofilament sensory differences despite an alleged even distribution of cutaneous afferents. Mechanical property…”
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Cooling reduces the cutaneous afferent firing response to vibratory stimuli in glabrous skin of the human foot sole
Published in Journal of neurophysiology (01-02-2013)“…Skin on the foot sole plays an important role in postural control. Cooling the skin of the foot is often used to induce anesthesia to determine the role of…”
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Selective skin sensitivity changes and sensory reweighting following short-duration space flight
Published in Journal of applied physiology (1985) (15-03-2014)“…Skin sensory input from the foot soles is coupled with vestibular input to facilitate body orientation in a gravitational environment. Anecdotal observations…”
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14
Drug discovery in ophthalmology: past success, present challenges, and future opportunities
Published in BMC ophthalmology (16-01-2016)“…Drug discovery has undergone major transformations in the last century, progressing from the recognition and refinement of natural products with therapeutic…”
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A review of the actions of Nitric Oxide in development and neuronal function in major invertebrate model systems
Published in AIMS neuroscience (01-01-2019)“…Ever since the late-eighties when endothelium-derived relaxing factor was found to be the gas nitric oxide, endogenous nitric oxide production has been…”
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16
Mannose-Presenting “Glyco-Colicins” Convert the Bacterial Cell Surface into a Multivalent Adsorption Site for Adherent Bacteria
Published in JACS Au (24-06-2024)“…Biofilm formation is integral to the pathogenesis of numerous adherent bacteria and contributes to antimicrobial resistance (AMR). The rising threat of AMR…”
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Both 50 and 30 Hz continuous theta burst transcranial magnetic stimulation depresses the cerebellum
Published in Cerebellum (London, England) (01-04-2019)“…The cerebellum is implicated in the pathophysiology of numerous movement disorders, which makes it an attractive target for noninvasive neurostimulation…”
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Selectivity and stability of N-terminal targeting protein modification chemistries
Published in RSC chemical biology (04-01-2023)“…Protein N-termini provide uniquely reactive motifs for single site protein modification. Though a number of reactions have been developed to target this site,…”
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Evolution of the techniques used in studying associative olfactory learning and memory in adult Drosophila in vivo: a historical and technical perspective
Published in Invertebrate neuroscience (01-03-2014)“…Drosophila melanogaster behavioral mutants have been isolated in which the ability to form associative olfactory memories has been disrupted primarily by…”
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Effects of Surface Chemistry and Topology on the Kinesin-Driven Motility of Microtubule Shuttles
Published in ACS applied bio materials (16-11-2020)“…Nanoscale transport using the kinesin–microtubule system has been successfully used in applications ranging from self-assembly, to biosensing, to…”
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