Search Results - "Nicholas, J C"

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function by Spiteri, Alanna G., Wishart, Claire L., Pamphlett, Roger, Locatelli, Giuseppe, King, Nicholas J. C.

“…In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS parenchyma, may diverge from, or intersect with, those of recruited…”
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Fc receptors in antibody-dependent enhancement of viral infections by Taylor, Adam, Foo, Suan-Sin, Bruzzone, Roberto, Vu Dinh, Luan, King, Nicholas J. C., Mahalingam, Suresh

“…Summary Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire…”
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Microanatomy of incremental growth lines in dental tissues in reindeer Rangifer tarandus by Boyde, Alan, Tyler, Nicholas J C

“…Counting growth layers in dentine and/or secondary cementum is widely used for age determination in wild mammals but the underlying seasonal changes in the…”
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The potential of genomics for restoring ecosystems and biodiversity by Breed, Martin F., Harrison, Peter A., Blyth, Colette, Byrne, Margaret, Gaget, Virginie, Gellie, Nicholas J. C., Groom, Scott V. C., Hodgson, Riley, Mills, Jacob G., Prowse, Thomas A. A., Steane, Dorothy A., Mohr, Jakki J.

“…Billions of hectares of natural ecosystems have been degraded through human actions. The global community has agreed on targets to halt and reverse these…”
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Activity patterns in mammals: Circadian dominance challenged by Hazlerigg, David G, Tyler, Nicholas J C

“…The evidence that diel patterns of physiology and behaviour in mammals are governed by circadian 'clocks' is based almost entirely on studies of nocturnal…”
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Urban habitat restoration provides a human health benefit through microbiome rewilding: the Microbiome Rewilding Hypothesis by Mills, Jacob G., Weinstein, Philip, Gellie, Nicholas J. C., Weyrich, Laura S., Lowe, Andrew J., Breed, Martin F.

“…Restoration aims to return ecosystem services, including the human health benefits of exposure to green space. The loss of such exposure with urbanization and…”
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Ecological Dynamics Across the Arctic Associated with Recent Climate Change by Post, Eric, Forchhammer, Mads C, Bret-Harte, M. Syndonia, Callaghan, Terry V, Christensen, Torben R, Elberling, Bo, Fox, Anthony D, Gilg, Olivier, Hik, David S, Høye, Toke T, Ims, Rolf A, Jeppesen, Erik, Klein, David R, Madsen, Jesper, McGuire, A. David, Rysgaard, Søren, Schindler, Daniel E, Stirling, Ian, Tamstorf, Mikkel P, Tyler, Nicholas J.C, van der Wal, Rene, Welker, Jeffrey, Wookey, Philip A, Schmidt, Niels Martin, Aastrup, Peter

“…At the close of the Fourth International Polar Year, we take stock of the ecological consequences of recent climate change in the Arctic, focusing on effects…”
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Can live-attenuated SARS-CoV-2 vaccine contribute to stopping the pandemic? by Tang, Patrick Chun Hean, Ng, Wern Hann, King, Nicholas J C, Mahalingam, Suresh

“…There is a small number of other reported LAV that have shown utility in animal models of COVID-19 [3,4], such as a temperature-sensitive Severe Acute…”
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Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation by Jeong, Gi Uk, Kwon, Hyung-Jun, Ng, Wern Hann, Liu, Xiang, Moon, Hyun Woo, Yoon, Gun Young, Shin, Hye Jin, Lee, In-Chul, Ling, Zheng Lung, Spiteri, Alanna G., King, Nicholas J. C., Taylor, Adam, Chae, Ji Soo, Kim, Chonsaeng, Ahn, Dae-Gyun, Kim, Kyun-Do, Ryu, Young Bae, Kim, Seong-Jun, Mahalingam, Suresh, Kwon, Young-Chan

“…Although ocular manifestations are reported in patients with COVID-19, consensus on ocular tropism of SARS-CoV-2 is lacking. Here, we infect K18-hACE2…”
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IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS by Minten, Carsten, Terry, Rachael, Deffrasnes, Celine, King, Nicholas J C, Campbell, Iain L

“…IFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation…”
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Sanfilippo syndrome: consensus guidelines for clinical care by Muschol, Nicole, Giugliani, Roberto, Jones, Simon A, Muenzer, Joseph, Smith, Nicholas J. C, Whitley, Chester B, Donnell, Megan, Drake, Elise, Elvidge, Kristina, Melton, Lisa, O'Neill, Cara

“…Abstract Sanfilippo syndrome is a group of rare, complex, and progressive neurodegenerative lysosomal storage disorders that is characterized by childhood…”
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Syncope in a Middle-aged Man: A Revealing Electrocardiogram by Lee, Nicholas C J, Chidester, Jeffrey P, McGuire, Darren K

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Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy by Eichler, Florian, Duncan, Christine, Musolino, Patricia L, Orchard, Paul J, De Oliveira, Satiro, Thrasher, Adrian J, Armant, Myriam, Dansereau, Colleen, Lund, Troy C, Miller, Weston P, Raymond, Gerald V, Sankar, Raman, Shah, Ami J, Sevin, Caroline, Gaspar, H. Bobby, Gissen, Paul, Amartino, Hernan, Bratkovic, Drago, Smith, Nicholas J.C, Paker, Asif M, Shamir, Esther, O’Meara, Tara, Davidson, David, Aubourg, Patrick, Williams, David A

“…Among boys with cerebral adrenoleukodystrophy, matched donors for allogeneic transplantation are available to only a few. Infusion of CD34+ autologous stem…”
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Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection by Jung, So Ri, Ashhurst, Thomas M, West, Phillip K, Viengkhou, Barney, King, Nicholas J C, Campbell, Iain L, Hofer, Markus J

“…Signal transducers and activators of transcription (STAT) 1 is critical for cellular responses to type I interferons (IFN-Is), with the capacity to determine…”
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FHL1 promotes chikungunya and o’nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design by Ng, Wern Hann, Liu, Xiang, Ling, Zheng L., Santos, Camilla N. O., Magalhães, Lucas S., Kueh, Andrew J., Herold, Marco J., Taylor, Adam, Freitas, Joseph R., Koit, Sandra, Wang, Sainan, Lloyd, Andrew R., Teixeira, Mauro M., Merits, Andres, Almeida, Roque P., King, Nicholas J. C., Mahalingam, Suresh

“…Arthritogenic alphaviruses are positive-strand RNA viruses that cause debilitating musculoskeletal diseases affecting millions worldwide. A recent discovery…”
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High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease by Spiteri, Alanna G, Terry, Rachel L, Wishart, Claire L, Ashhurst, Thomas M, Campbell, Iain L, Hofer, Markus J, King, Nicholas J C

“…Differentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory…”
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A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants by Liu, Xiang, Ng, Wern Hann, Zusinaite, Eva, Freitas, Joseph, Taylor, Adam, Yerragunta, Venugopal, Aavula, Shukra Madhaha, Gorriparthi, Sambaiah, Ponsekaran, Santhakumar, Bonda, Rama Lakshmi, Mani, Priyanka, Nimmagadda, Sridevi V., Wang, Sainan, Lello, Laura Sandra, Zaid, Ali, Dua, Ujjwal, Taft-Benz, Sharon A., Anderson, Elizabeth, Baxter, Victoria K., Sarkar, Sanjay, Ling, Zheng L., Ashhurst, Thomas M., Cheng, Samuel M. S., Pattnaik, Priyabrata, Kanakasapapathy, Anand Kumar, Baric, Ralph S., Burt, Felicity J., Peiris, Malik, Heise, Mark T., King, Nicholas J. C., Merits, Andres, Lingala, Rajendra, Mahalingam, Suresh

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) continues its significant health and economic impact globally. Despite the success of…”
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Therapeutic inflammatory monocyte modulation using immune-modifying microparticles by Getts, Daniel R, Terry, Rachael L, Getts, Meghann Teague, Deffrasnes, Celine, Müller, Marcus, van Vreden, Caryn, Ashhurst, Thomas M, Chami, Belal, McCarthy, Derrick, Wu, Huiling, Ma, Jin, Martin, Aaron, Shae, Lonnie D, Witting, Paul, Kansas, Geoffrey S, Kühn, Joachim, Hafezi, Wali, Campbell, Iain L, Reilly, David, Say, Jana, Brown, Louise, White, Melanie Y, Cordwell, Stuart J, Chadban, Steven J, Thorp, Edward B, Bao, Shisan, Miller, Stephen D, King, Nicholas J C

“…Inflammatory monocyte-derived effector cells play an important role in the pathogenesis of numerous inflammatory diseases. However, no treatment option exists…”
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The role of CXCR3 in DSS-induced colitis by Chami, Belal, Yeung, Amanda W S, van Vreden, Caryn, King, Nicholas J C, Bao, Shisan

“…Inflammatory bowel disease (IBD) is a group of disorders that are characterized by chronic, uncontrolled inflammation in the intestinal mucosa. Although the…”
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Relating Urban Biodiversity to Human Health With the 'Holobiont' Concept by Mills, Jacob G, Brookes, Justin D, Gellie, Nicholas J C, Liddicoat, Craig, Lowe, Andrew J, Sydnor, Harrison R, Thomas, Torsten, Weinstein, Philip, Weyrich, Laura S, Breed, Martin F

“…A relatively unaccounted ecosystem service from biodiversity is the benefit to human health via symbiotic microbiota from our environment. This benefit occurs…”
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