Search Results - "Nichol, Geoff"

Phase I/II Study of Ipilimumab for Patients With Metastatic Melanoma by WEBER, Jeffrey S, O'DAY, Steven, URBA, Walter, POWDERLY, John, NICHOL, Geoff, YELLIN, Michael, SNIVELY, Jolie, HERSH, Evan

“…The primary objective of this phase I/II study was to determine the safety and pharmacokinetic profile of either transfectoma- or a hybridoma-derived…”
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Autoimmunity Correlates With Tumor Regression in Patients With Metastatic Melanoma Treated With Anti–Cytotoxic T-Lymphocyte Antigen-4 by ATTIA, Peter, PHAN, Giao Q, RESTIFO, Nicholas P, HAWORTH, Leah R, LEVY, Catherine, MAVROUKAKIS, Sharon A, NICHOL, Geoff, YELLIN, Michael J, ROSENBERG, Steven A, MAKER, Ajay V, ROBINSON, Michael R, QUEZADO, Martha M, YANG, James C, SHERRY, Richard M, TOPALIAN, Suzanne L, KAMMULA, Udai S, ROYAL, Richard E

“…Previously, we reported our experience treating 14 patients with metastatic melanoma using a fully human antibody to cytotoxic T-lymphocyte antigen-4…”
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ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates by Wechsler, Thomas, Meyer, Kathleen E., Spratt, S. Kaye, Greengard, Judith, Santiago, Yolanda, Sproul, Scott, Surosky, Richard, Paschon, David E., Dubois-Stringfellow, Nathalie, Ando, Dale Genji, Nichol, Geoff, Rebar, Edward J., Holmes, Michael C.

“…Hemophilia is an attractive target for gene therapy, since activity levels as low as 1% to 2% of normal are beneficial and levels of ~5% prevent spontaneous…”
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Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV by Tebas, Pablo, Stein, David, Tang, Winson W, Frank, Ian, Wang, Shelley Q, Lee, Gary, Spratt, S. Kaye, Surosky, Richard T, Giedlin, Martin A, Nichol, Geoff, Holmes, Michael C, Gregory, Philip D, Ando, Dale G, Kalos, Michael, Collman, Ronald G, Binder-Scholl, Gwendolyn, Plesa, Gabriela, Hwang, Wei-Ting, Levine, Bruce L, June, Carl H

“…In this small study, investigators genetically disrupted the HIV receptor CCR5 in CD4 T cells of aviremic persons who were infected with HIV. After reinfusion…”
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A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis by Yellin, Michael, Paliienko, Igor, Balanescu, Andra, Ter-Vartanian, Semen, Tseluyko, Vira, Xu, Li-An, Tao, Xiaolu, Cardarelli, Pina M., LeBlanc, Heidi, Nichol, Geoff, Ancuta, Codrina, Chirieac, Rodica, Luo, Allison

“…Objective CXCL10 (also known as interferon‐γ–inducible 10‐kd protein [IP‐10]) is a chemokine that potentially plays a role in the immunopathogenesis of…”
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Extended Dose Ipilimumab with a Peptide Vaccine: Immune Correlates Associated with Clinical Benefit in Patients with Resected High-Risk Stage IIIc/IV Melanoma by SARNAIK, Amod A, BIN YU, YELLIN, Michael, WEBER, Jeffrey S, DAOHAI YU, DAWN MORELLI, HALL, Maclean, BOGLE, Dilip, LULU YAN, TARGAN, Stephan, SOLOMON, Jolie, NICHOL, Geoff

“…To determine safety and feasibility of adjuvant ipilimumab following resection of high-risk melanoma and to identify surrogate markers for benefit. In this…”
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C-7. Adoptive Transfer of ZFN Mediated CCR5 Modified CD4 T-cells (SB-728-T) in HIV Subjects Leads to Long Term Engraftment of HIV Resistant T Memory Stem Cells and Decrease in Size of Latent Reservoir by Zeidan, Joumana, Lee, Gary, Fromentin, Remy, Lalezari, Jacob, Mitsuyasu, Ronald, Wang, Shelley, Giedlin, Martin A., Nichol, Geoff, Tang, Winson, Chomont, Nicholas, Ando, Dale, Sekaly, Rafick-Pierre

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684. Enhanced FVIII AAV Vector Cassette Produces Improved Virus Yields and Supraphysiological FVIII Levels In Vivo by Riley, Brigit, Boonsripisal, Jeff, Goodwin, Alicia, Garces, Eudean, Ballaron, Stephen, Tran, Hung, Kang, Andrea, Zhang, Lei, Greengard, Judy, Surosky, Richard, Meyer, Kathleen, Ando, Dale, Nichol, Geoff, Holmes, Michael C.

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Development of an Optimized rAAV2/6 Human Factor 8 cDNA Vector Cassette for Hemophilia a Gene Therapy by Riley, Brigit E., Boonsripisal, Jeff, Goodwin, Alicia, Cartier, Dominique, Garces, Eudean, Nesbitt, Kate, Dwyer, Courtney, Ballaron, Stephen, Hebert, Kassandra, Tran, Hung, Kang, Andrea, Zhang, Lei, Meyer, Kathleen E., Greengard, Judith, Hough, Christine, Surosky, Richard, Ando, Dale Genji, Lillicrap, David, Nichol, Geoff, Holmes, Michael C.

“…Hemophilia A, which is caused by a mutation in the Factor 8 (F8) gene resulting in a deficiency or lack of the Factor VIII (FVIII) protein, is the most common…”
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Effects of prostacyclin on bronchoconstriction and neutropenia induced by inhaled platelet-activating factor in man by Lammers, J W, Kioumis, I, McCusker, M, Nichol, G M, Barnes, P J, Chung, K F

“…We studied the effects of prostacyclin (PGI2) on the airway responses to platelet-activating factor (PAF) in a randomized and crossover study in eight normal…”
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Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin by Ventresca, P G, Nichol, G M, Barnes, P J, Chung, K F

“…Inhaled furosemide prevents bronchoconstriction induced by nebulized distilled water, exercise, and antigen challenge. We examined the effect of furosemide on…”
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