Effect of sodium metabisulphite on bronchial blood flow in conscious sheep: pharmacological modulation

1 Sodium metabisulphite (MBS) can induce bronchoconstriction in patients with asthma. We investigated the effects of MBS aerosol on bronchial blood velocity (Vbr) and pulmonary resistance in intubated conscious sheep. 2 Bronchial blood velocity was measured by implanting a 20 MHz ultrasonic Doppler...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 111; no. 3; pp. 918 - 922
Main Authors:	Nichol, G.M., Parsons, G.H., Chung, K.F.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-03-1994 Nature Publishing
Subjects:	Administration, Inhalation Aerosols Animals Biological and medical sciences Bronchi - blood supply Bronchial blood flow Chemical and industrial products toxicology. Toxic occupational diseases Cholinergic Antagonists Consciousness Dose-Response Relationship, Drug frusemide Furosemide - pharmacology histamine Histamine H1 Antagonists - pharmacology Histamine H2 Antagonists - pharmacology ipratropium bromide Medical sciences Metals and various inorganic compounds Nedocromil - pharmacology nedocromil sodium Pulmonary Circulation - drug effects Sheep sodium metabisulphite Sulfites - pharmacokinetics Sulfites - pharmacology Tachyphylaxis Toxicology Vascular Resistance - drug effects Vasodilator agent Respiratory disease Toxicity Sodium Disulfites Respiratory system Inhalation Vertebrata Bronchoconstriction Mammalia Preservative Animal Sheep Artiodactyla Hemodynamics Mechanism of action Ungulata
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Summary:	1 Sodium metabisulphite (MBS) can induce bronchoconstriction in patients with asthma. We investigated the effects of MBS aerosol on bronchial blood velocity (Vbr) and pulmonary resistance in intubated conscious sheep. 2 Bronchial blood velocity was measured by implanting a 20 MHz ultrasonic Doppler flow probe on the common bronchial branch of the bronchoesophageal artery. 3 Inhaled MBS induced a dose‐dependent, transient increase in Vbr lasting for a few minutes without any changes in aortic and pulmonary artery pressures. There was some tachyphylaxis of the Vbr response to successive inhalations of MBS. 4 The cholinoceptor antagonist, ipratropium bromide and the H1 and H2 histamine antagonists, chlorpheniramine and cimetidine, had no significant effect on MBS‐induced increase on Vbr. The loop diuretic, frusemide, and the anti‐inflammatory drug, nedocromil sodium, which both inhibit MBS‐induced bronchoconstriction in patients with asthma, were also without effect. 5 We conclude that MBS induces bronchial vasodilatation in conscious sheep, and that this effect is not dependent on the release of histamine or other mediators, or an activation of cholinergic pathways.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1994.tb14826.x