Search Results - "Nichol, Charles A."

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine by Grivsky, Eugene M, Lee, Shuliang, Sigel, Carl W, Duch, David S, Nichol, Charles A

“…The synthesis of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW301U, 7) by a route that has general applicability to the preparation…”
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Biochemical and chemotherapeutic studies on 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW 301U), a novel lipid-soluble inhibitor of dihydrofolate reductase by Duch, D S, Edelstein, M P, Bowers, S W, Nichol, C A

“…The lipophilic diaminopyridopyrimidine BW 301U (2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine) is as active as methotrexate as an…”
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Biopterin Cofactor Biosynthesis: Independent Regulation of GTP Cyclohydrolase in Adrenal Medulla and Cortex by Viveros, O. Humberto, Lee, Ching-Lun, Abou-Donia, Martha M., Nixon, Jon C., Nichol, Charles A.

“…Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of…”
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Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography by Woolf, J H, Nichol, C A, Duch, D S

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Urinary biopterin and neopterin excretion and pituitary-adrenal activity in psychiatric patients by Garbutt, J C, Duch, D S, Nichol, C A, Woolf, J H

“…The urinary excretion of biopterin and neopterin, pterin compounds related to tetrahydrobiopterin, the cofactor for the initial steps in monoamine synthesis,…”
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Some pharmacologic considerations concerning the control of acute leukemia by Nichol, C A

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The manipulation of metabolism by drugs and nutrients by Nichol, C A

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Tetrahydrofolate Cofactors in Tissues Sensitive and Refractory to Amethopterin by Sotobayashi, Hidenori, Rosen, Fred, Nichol, Charles A

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The application of new knowledge to the effective administration of anticancer agents by Nichol, C A

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Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth by Duch, D S, Bigner, D D, Bowers, S W, Nichol, C A

“…Dihydrofolate reductase (DHFR) was measured during the development in rats of brain tumors induced following inoculation with avian sarcoma virus. Increasing…”
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Kethoxal bis(thiosemicarbazone). I. Effects against experimental tumors by Mihich, E, Nichol, C A

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Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections by Nathan, H C, Bacchi, C J, Nichol, C A, Duch, D S, Mullaney, E A, Hutner, S H

“…A series of phthalanilides and related compounds were tested on a short-term, fulminating, mouse infection of Trypanosoma brucei brucei (EATRO 110 isolate)…”
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Elevation of brain histamine levels by diaminopyrimidine inhibitors of histamine N-methyl transferase by Duch, D S, Bowers, S W, Nichol, C A

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Selection of Bacterial Mutants of Increased Sensitivity to 'Aminopterin' by NICHOL, CHARLES A

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Studies of the mechanism of resistance to folic acid antagonists by leukemic cells by NICHOL, C A

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Induction of Several Adaptive Enzymes by Actinomycin D by Rosen, Fred, Raina, Prem Nath, Milholland, Richard J., Nichol, Charles A.

“…Although actinomycin D has been used to prevent protein synthesis in experiments of several hours' duration, its effects on the synthesis of adaptive enzymes…”
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Development of a Sub-Line of Mouse Sarcoma-180 Capable of Growing in Pyridoxine-Deficient Animals by MIHICH, ENRICO, NICHOL, CHARLES A

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Biosynthesis and Metabolism of Tetrahydrobiopterin and Molybdopterin by Nichol, C A, Smith, G K, Duch, D S

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Metabolism of neoplastic cells and their response to certain drugs by NICHOL, C A

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Studies on the biologic activity and mode of action of 7-deazainosine by Bloch, A, Mihich, E, Leonard, R J, Nichol, C A

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