Search Results - "Nichani, Anil K."

Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides by Mutwiri, George K, Nichani, Anil K, Babiuk, Shawn, Babiuk, Lorne A

“…Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a “danger” signal by the immune system of mammals. As a consequence, CpG ODN…”
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Quantitative analysis of pro-inflammatory cytokine mRNA expression in Theileria annulata-infected cell lines derived from resistant and susceptible cattle by McGuire, Kirsty, Manuja, Anju, Russell, George C., Springbett, Anthea, Craigmile, Susan C., Nichani, Anil K., Malhotra, D.V., Glass, Elizabeth J.

“…The pathogenic mechanisms involved in tropical theileriosis, caused by the tick-borne protozoan parasite Theileria annulata, are unclear. Pathology is…”
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Innate immune responses induced by classes of CpG oligodeoxynucleotides in ovine lymph node and blood mononuclear cells by Booth, Jayaum S., Nichani, Anil K., Benjamin, Ponn, Dar, Arshud, Krieg, Arthur M., Babiuk, Lorne A., Mutwiri, George K.

“…CpG ODN signal through Toll-like receptor 9 (TLR9) and trigger a cascade of events that lead to activation of innate and adaptive immune responses. Our current…”
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Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNα-producing cells and TLR9 mRNA expression by Dar, Arshud, Nichani, Anil K., Benjamin, Ponn, Lai, Ken, Soita, Henry, Krieg, Arthur M., Potter, Andrew, Babiuk, Lorne A., Mutwiri, George K.

“…The immune stimulatory effects of synthetic CpG DNA, on porcine peripheral blood mononuclear cells (PBMC) have been reported, but little is known about…”
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Subcutaneous, but not intratracheal administration of the TLR9 agonist, CpG DNA transiently reduces parainfluenza-3 virus shedding in newborn lambs by Nichani, Anil K, Dar, M. Arshad, Mirakhur, Kuldip K, Krieg, Arthur M, Booth, Jayaum S, Townsend, Hugh G.G, Potter, Andrew A, Babiuk, Lorne A, Mutwiri, George K

“…Abstract Synthetic oligodeoxynucleotides (ODN) containing CpG motifs signal through TLR9 and activate innate immunity resulting in protection against a variety…”
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Innate immune responses induced by CpG oligodeoxyribonucleotide stimulation of ovine blood mononuclear cells by Mena, Angelo, Nichani, Anil K., Popowych, Yurij, Godson, Dale L., Dent, Donna, Townsend, Hugh G. G., Mutwiri, George K., Hecker, Rolf, Babiuk, Lorne A., Griebel, Philip

“…Summary Examples exist in the literature that demonstrate that treatment with immunostimulatory cytosine–phosphate–guanosine (CpG)‐DNA can protect mice against…”
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CpG oligodeoxynucleotide induction of antiviral effector molecules in sheep by Nichani, Anil K., Kaushik, Radhey S., Mena, Angelo, Popowych, Yurij, Dent, Donna, Townsend, Hugh G.G., Mutwiri, George, Hecker, Rolf, Babiuk, Lorne A., Griebel, Philip J.

“…Immunostimulatory CpG oligodeoxynucleotide (ODN) can protect mice against infection by many pathogens but the mechanisms mediating disease protection are not…”
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Proinflammatory cytokine expression by Theileria annulata infected cell lines correlates with the pathology they cause in vivo by Graham, Simon P, Brown, David J, Vatansever, Zati, Waddington, David, Taylor, Louise H, Nichani, Anil K, Campbell, John D.M, Adamson, Rachel E, Glass, Elizabeth J, Spooner, Roger L

“…Control of Theileria annulata is currently best achieved by the use of live attenuated cell line vaccines. However, the mechanisms underlying attenuation are…”
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Standardisation and comparison of serial dilution and single dilution enzyme linked immunosorbent assay (ELISA) using different antigenic preparations of the Babesia (Theileria) equi parasite by Kumar, Sanjay, Kumar, Yogesh, Malhotra, Dharam V, Dhar, Shruti, Nichani, Anil K

“…Serial dilution and single dilution enzyme linked immunosorbent assays (ELISA) were standardised and their sensitivity and specificity were compared for…”
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Single dilution ELISAs using soluble piroplasm, cellular schizont and soluble schizont antigens for the detection of antibodies against Theileria annulata by Manuja, A, Nichani, A K, Kumar, R, Sharma, R D, Kumar, B

“…Single dilution ELISAs were standardised for the determination of antibody titres against Theileria annulata using three antigens namely soluble piroplasm,…”
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Systemic innate immune responses following intrapulmonary delivery of CpG oligodeoxynucleotides in sheep by Nichani, Anil K., Dar, M. Arshud, Krieg, Arthur M., Mirakhur, Kuldip K., Kaushik, Radhey S., Griebel, Philip J., Manuja, Anju, Townsend, Hugh G.G., Babiuk, Lorne A., Mutwiri, George K.

“…Mucosal delivery of CpG oligodeoxynucleotide (ODN) in mice has been shown to induce potent innate immunostimulatory responses and protection against infection…”
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Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpesvirus-1 shedding by Nichani, Anil K, Mena, Angelo, Kaushik, Radhey S, Mutwiri, George K, Townsend, Hugh G G, Hecker, Rolf, Krieg, Arthur M, Babiuk, Lorne A, Griebel, Philip J

“…Stimulation of the innate immune system is potentially very important in neonates who have an immature adaptive immune system and vaccination cannot be used to…”
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Bovine and ovine blood mononuclear leukocytes differ markedly in innate immune responses induced by Class A and Class B CpG-oligodeoxynucleotide by Mena, Angelo, Nichani, Anil K, Popowych, Yurij, Ioannou, Xenia P, Godson, Dale L, Mutwiri, George K, Hecker, Rolf, Babiuk, Lorne A, Griebel, Philip

“…Cytosine-phosphate-guanosine (CpG)-DNA can induce an impressive array of innate immune responses that may directly or indirectly contribute to the clearance of…”
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Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNalpha-producing cells and TLR9 mRNA expression by Dar, Arshud, Nichani, Anil K, Benjamin, Ponn, Lai, Ken, Soita, Henry, Krieg, Arthur M, Potter, Andrew, Babiuk, Lorne A, Mutwiri, George K

“…The immune stimulatory effects of synthetic CpG DNA, on porcine peripheral blood mononuclear cells (PBMC) have been reported, but little is known about…”
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Revaccination with the sameTheileria annulata infected cell line may not be feasible for boosting immunity against tropical theileriosis by Nichani, Anil K., Brown, C. G. D., Spooner, Roger L.

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Parasite-Mediated Steps in Immune Response Failure During PrimaryTheileria AnnulataInfection by Campbell, John D. M., Nichani, Anil K., Brown, David J., Howie, Sarah E. M., Spooner, Roger L., Glass, Elizabeth J.

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Transfection, expression, and DNA sequence of a gene encoding a BoLA-A11 antigen by Sawhney, S M, Hasima, N N, Glass, E J, al-Murrani, S W, Nichani, A K, Spooner, R L, Williams, J L, Russell, G C

“…Cattle major histocompatibility complex [(MHC) (BoLA)] class I molecules are heterodimeric glycoproteins which present endogenous antigenic peptides to CD8…”
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