Role of HbA1c in diagnosis of gestational diabetes mellitus

Role of HbA1c in diagnosis of gestational diabetes mellitus

To evaluate glycated haemoglobin as a biomarker for diagnosing gestational diabetes mellitus while keeping the oral glucose tolerance test as the gold standard. The cross-sectional study was conducted from Januray, 2016, to January, 2018, at PNS Hafeez Hospital, Islamabad, Pakistan and comprised of...

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Published in:Journal of the Pakistan Medical Association Vol. 70; no. 10; pp. 1731 - 1736
Main Authors: Khan, Sikandar Hayat, Manzoor, Robina, Baig, Aasyia Hanif, Tariq, Beenish, Ayub, Nadia, Sarwar, Sana, Manzoor, Syed Mohsin, Fazal, Nadeem, Nadeem, Ahmed, Nadeem, Mishal, Niazi, Najumusaqib Khan
Format: Journal Article
Language:English
Published: Pakistan Knowledge Bylanes 01-10-2020
Subjects:
Blood Glucose
Cross-Sectional Studies
Development and progression
Diabetes Mellitus
Diabetes, Gestational - diagnosis
Diabetes, Gestational - epidemiology
Diagnosis
Female
Gestational diabetes
Glycated Hemoglobin A - analysis
Glycosylated hemoglobin
Health aspects
Humans
Pakistan
Physiological aspects
Pregnancy
Pakistan
HbA1c, Gestational diabetes mellitus, 2-hour OGTT
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Summary:To evaluate glycated haemoglobin as a biomarker for diagnosing gestational diabetes mellitus while keeping the oral glucose tolerance test as the gold standard. The cross-sectional study was conducted from Januray, 2016, to January, 2018, at PNS Hafeez Hospital, Islamabad, Pakistan and comprised of pregnant subjects who were first subjected to 2-hour oral glucose tolerance test along with the first evaluation of glycated haemoglobin. Clinical evaluation, including history and measurements of anthropometric indices and blood pressure, were also done. On the basis of the results, the subjects were grouped as those having gestational diabetes mellitus (group A) and those without it (group B). Data was analysed using SPSS 15. Of the 280 subjects, gestational diabetes mellitus was found in 50(17.85%). Differences in glycated haemoglobin between the groups was significant (p<0.002). Glycated haemoglobin test provided sensitivity of 70% and specificity of 84.78%. With due adjustments, glycated haemoglobin testing can help in reducing the frequency of oral glucose tolerance test.
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ISSN:0030-9982
DOI:10.5455/JPMA.24080