Mechanisms of dynamic nuclear polarization in insulating solids

Mechanisms of dynamic nuclear polarization in insulating solids

[Display omitted] •Overhauser effect exists in insulating solids and appears to scale with B0.•Cross effect DNP gives an enhancement of 400 at 9T using AMUPol biradical.•Pulsed DNP on samples dope with BDPA or nitroxide radicals gives enhancement as high as 100. Dynamic nuclear polarization (DNP) is...

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Bibliographic Details
Published in:Journal of magnetic resonance (1997) Vol. 253; pp. 23 - 35
Main Authors: Can, T.V., Ni, Q.Z., Griffin, R.G.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-04-2015
Subjects:
Algorithms
Cross effect
Dynamic nuclear polarization (DNP)
Electric Conductivity
Models, Chemical
Nuclear Magnetic Resonance, Biomolecular - methods
Overhauser effect
Protein NMR
Proteins - analysis
Proteins - chemistry
Pulsed DNP
Cross effect
Dynamic nuclear polarization (DNP)
Protein NMR
Pulsed DNP
Overhauser effect
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Summary:[Display omitted] •Overhauser effect exists in insulating solids and appears to scale with B0.•Cross effect DNP gives an enhancement of 400 at 9T using AMUPol biradical.•Pulsed DNP on samples dope with BDPA or nitroxide radicals gives enhancement as high as 100. Dynamic nuclear polarization (DNP) is a technique used to enhance signal intensities in NMR experiments by transferring the high polarization of electrons to their surrounding nuclei. The past decade has witnessed a renaissance in the development of DNP, especially at high magnetic fields, and its application in several areas including biophysics, chemistry, structural biology and materials science. Recent technical and theoretical advances have expanded our understanding of established experiments: for example, the cross effect DNP in samples spinning at the magic angle. Furthermore, new experiments suggest that our understanding of the Overhauser effect and its applicability to insulating solids needs to be re-examined. In this article, we summarize important results of the past few years and provide quantum mechanical explanations underlying these results. We also discuss future directions of DNP and current limitations, including the problem of resolution in protein spectra recorded at 80–100K.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ISSN:1090-7807
1096-0856
DOI:10.1016/j.jmr.2015.02.005